Eugen J. Schoenle
Boston Children's Hospital
Publications 70
#1Christopher Patterson ('QUB': Queen's University Belfast)H-Index: 76
#2Valma HarjutsaloH-Index: 23
Last.Anders Green (University of Southern Denmark)H-Index: 33
view all 27 authors...
Aims/hypothesis Against a background of a near-universally increasing incidence of childhood type 1 diabetes, recent reports from some countries suggest a slowing in this increase. Occasional reports also describe cyclical variations in incidence, with periodicities of between 4 and 6 years.
23 CitationsSource
#1Karine Gerster (Boston Children's Hospital)H-Index: 1
#2Anna Biason-Lauber (University of Fribourg)H-Index: 20
Last.Eugen J. Schoenle (Boston Children's Hospital)H-Index: 34
view all 3 authors...
Abstract Objective Steroidogenic factor 1 ( SF-1/NR5A1 ) plays a crucial role in regulating adrenal development, gonad determination and differentiation, and in the hypothalamic-pituitary control of reproduction and metabolism. In men (46, XY), it is known that mutations in SF-1/NR5A1 gene cause a wide phenotypic spectrum with variable degrees of undervirilization. In recent years, the role of SF-1 in the ovarian function was increasingly discussed and alterations in the gene were related to pri...
#1Christopher Patterson ('QUB': Queen's University Belfast)H-Index: 76
#2Éva Gyürüs (PTE: University of Pécs)H-Index: 6
Last.Gisela Dahlquist (Umeå University)H-Index: 49
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BACKGROUND: The month of diagnosis in childhood type 1 diabetes shows seasonal variation.OBJECTIVE: We describe the pattern and investigate if year-to-year irregularities are associated with meteor ...
17 CitationsSource
#1Siew Hung Chin (UZH: University of Zurich)H-Index: 2
#2Flurin Item (Boston Children's Hospital)H-Index: 9
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
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Reduced kidney mass and/or function may result in multiple metabolic derangements, including insulin resistance. However, underlying mechanisms are poorly understood. Herein, we aimed to determine the impact of reduced kidney mass on glucose metabolism in lean and obese mice. To that end, seven-week-old C57BL6/J mice underwent uninephrectomy (UniNx) or sham operation. After surgery, animals were fed either a chow (standard) or a high fat diet (HFD) and glucose homeostasis was assessed 20 weeks a...
5 CitationsSource
Background/Aims: Primary hypoaldosteronism is a rare inborn disorder with life-threatening symptoms in newborns and infants due to an aldosterone synthase defect.
#1Stephan Wueest (Boston Children's Hospital)H-Index: 15
#2Flurin Item (Boston Children's Hospital)H-Index: 9
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 13 authors...
Contracting muscle releases interleukin-6 (IL-6) enabling the metabolic switch from carbohydrate to fat utilization. Similarly, metabolism is switched during transition from fed to fasting state. Herein, we examined a putative role for IL-6 in the metabolic adaptation to normal fasting. In lean C57BL/6J mice, 6 h of food withdrawal increased gene transcription levels of IL-6 in skeletal muscle but not in white adipose tissue. Concomitantly, circulating IL-6 and free fatty acid (FFA) levels were ...
22 CitationsSource
#1Michael Sf Wiedemann (UZH: University of Zurich)H-Index: 1
#2Stephan Wueest (Boston Children's Hospital)H-Index: 15
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 6
view all 6 authors...
A short bout of high fat diet (HFD) impairs glucose tolerance and hepatic insulin sensitivity. We recently identified adipose tissue inflammation and resulting dysfunctional adipose tissue–liver cross-talk as an early event in the development of HFD-induced hepatic insulin resistance. In particular, reducing white adipose tissue (WAT) inflammation by adipocyte-specific depletion of Fas/CD95 protected mice from developing hepatic insulin resistance but not hepatic steatosis. Herein, we expanded o...
6 CitationsSource
#1Matthias Blüher (Leipzig University)H-Index: 79
#2Nora Klöting (Leipzig University)H-Index: 41
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 9 authors...
Context: Deletion of the death receptor Fas (CD95) in adipocytes of mice is associated with improved insulin sensitivity and reduced adipose tissue (AT) inflammation. Objective: Here we investigate the relationship of AT Fas with human obesity. Design and Methods: In paired samples of omental and sc AT from 256 lean and obese (including insulin-sensitive and insulin-resistant subgroups; n = 60) participants, we investigated whether Fas and Fas-ligand (FasL) mRNA expression is fat depot-specific,...
17 CitationsSource
#1Stephan Wueest (Boston Children's Hospital)H-Index: 15
#2Rouven Mueller (UZH: University of Zurich)H-Index: 1
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 12 authors...
Low-grade inflammation in adipose tissue and liver has been implicated in obesity-associated insulin resistance and type 2 diabetes. Yet, the contribution of inflammatory cells to the pathogenesis of skeletal muscle insulin resistance remains elusive. In a large cohort of obese human individuals, blood monocyte Fas (CD95) expression correlated with systemic and skeletal muscle insulin resistance. To test a causal role for myeloid cell Fas expression in the development of skeletal muscle insulin ...
11 CitationsSource
#1Carine de BeaufortH-Index: 22
#2Karin LangeH-Index: 22
Last.Henrik B. MortensenH-Index: 36
view all 23 authors...
1 CitationsSource