Icons / Logo / Facebook Created with Sketch. Icons / Logo / Google Created with Sketch. Icons / Logo / ORCID Created with Sketch. Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!
Eugen J. Schoenle
Boston Children's Hospital
110Publications
40H-index
6,390Citations
Publications 110
Newest
Published on Mar 1, 2019in Diabetologia 7.11
Christopher C. Patterson72
Estimated H-index: 72
('QUB': Queen's University Belfast),
Valma Harjutsalo23
Estimated H-index: 23
+ 24 AuthorsRoger Parslow31
Estimated H-index: 31
(University of Leeds)
Aims/hypothesis Against a background of a near-universally increasing incidence of childhood type 1 diabetes, recent reports from some countries suggest a slowing in this increase. Occasional reports also describe cyclical variations in incidence, with periodicities of between 4 and 6 years.
Published on Jul 1, 2017in Annales D Endocrinologie 1.43
Karine Gerster1
Estimated H-index: 1
(Boston Children's Hospital),
Anna Biason-Lauber20
Estimated H-index: 20
(University of Fribourg),
Eugen J. Schoenle40
Estimated H-index: 40
(Boston Children's Hospital)
Abstract Objective Steroidogenic factor 1 ( SF-1/NR5A1 ) plays a crucial role in regulating adrenal development, gonad determination and differentiation, and in the hypothalamic-pituitary control of reproduction and metabolism. In men (46, XY), it is known that mutations in SF-1/NR5A1 gene cause a wide phenotypic spectrum with variable degrees of undervirilization. In recent years, the role of SF-1 in the ovarian function was increasingly discussed and alterations in the gene were related to pri...
Published on Dec 1, 2015in Pediatric Diabetes 3.35
Christopher C. Patterson72
Estimated H-index: 72
('QUB': Queen's University Belfast),
Éva Gyürüs6
Estimated H-index: 6
(PTE: University of Pécs)
+ 22 AuthorsC Castell3
Estimated H-index: 3
BACKGROUND: The month of diagnosis in childhood type 1 diabetes shows seasonal variation.OBJECTIVE: We describe the pattern and investigate if year-to-year irregularities are associated with meteor ...
Published on Apr 1, 2015in Diabetes 7.20
Siew Hung Chin2
Estimated H-index: 2
(UZH: University of Zurich),
Flurin Item8
Estimated H-index: 8
(Boston Children's Hospital)
+ 7 AuthorsDaniel Konrad27
Estimated H-index: 27
(UZH: University of Zurich)
Reduced kidney mass and/or function may result in multiple metabolic derangements, including insulin resistance. However, underlying mechanisms are poorly understood. Herein, we aimed to determine the impact of reduced kidney mass on glucose metabolism in lean and obese mice. To that end, seven-week-old C57BL6/J mice underwent uninephrectomy (UniNx) or sham operation. After surgery, animals were fed either a chow (standard) or a high fat diet (HFD) and glucose homeostasis was assessed 20 weeks a...
Published on Jan 1, 2015in Hormone Research in Paediatrics 2.32
Beate Ruecker , Mariarosaria Lang-Muritano11
Estimated H-index: 11
+ 7 AuthorsEugen J. Schoenle40
Estimated H-index: 40
Background/Aims: Primary hypoaldosteronism is a rare inborn disorder with life-threatening symptoms in newborns and infants due to an aldosterone synthase defect.
Stephan Wueest15
Estimated H-index: 15
(Boston Children's Hospital),
Flurin Item8
Estimated H-index: 8
(Boston Children's Hospital)
+ 10 AuthorsMarc Y. Donath57
Estimated H-index: 57
(University of Basel)
Contracting muscle releases interleukin-6 (IL-6) enabling the metabolic switch from carbohydrate to fat utilization. Similarly, metabolism is switched during transition from fed to fasting state. Herein, we examined a putative role for IL-6 in the metabolic adaptation to normal fasting. In lean C57BL/6J mice, 6 h of food withdrawal increased gene transcription levels of IL-6 in skeletal muscle but not in white adipose tissue. Concomitantly, circulating IL-6 and free fatty acid (FFA) levels were ...
Published on Apr 8, 2014
Michael Sf Wiedemann1
Estimated H-index: 1
(UZH: University of Zurich),
Stephan Wueest15
Estimated H-index: 15
(Boston Children's Hospital)
+ 3 AuthorsDaniel Konrad27
Estimated H-index: 27
(UZH: University of Zurich)
A short bout of high fat diet (HFD) impairs glucose tolerance and hepatic insulin sensitivity. We recently identified adipose tissue inflammation and resulting dysfunctional adipose tissue–liver cross-talk as an early event in the development of HFD-induced hepatic insulin resistance. In particular, reducing white adipose tissue (WAT) inflammation by adipocyte-specific depletion of Fas/CD95 protected mice from developing hepatic insulin resistance but not hepatic steatosis. Herein, we expanded o...
Published on Jan 1, 2014in The Journal of Clinical Endocrinology and Metabolism 5.61
Matthias Blüher75
Estimated H-index: 75
(Leipzig University),
Nora Klöting41
Estimated H-index: 41
(Leipzig University)
+ 6 AuthorsDaniel Konrad27
Estimated H-index: 27
(UZH: University of Zurich)
Context: Deletion of the death receptor Fas (CD95) in adipocytes of mice is associated with improved insulin sensitivity and reduced adipose tissue (AT) inflammation. Objective: Here we investigate the relationship of AT Fas with human obesity. Design and Methods: In paired samples of omental and sc AT from 256 lean and obese (including insulin-sensitive and insulin-resistant subgroups; n = 60) participants, we investigated whether Fas and Fas-ligand (FasL) mRNA expression is fat depot-specific,...
Published on Jan 1, 2014in Embo Molecular Medicine 10.62
Stephan Wueest15
Estimated H-index: 15
(Boston Children's Hospital),
Rouven Mueller1
Estimated H-index: 1
(UZH: University of Zurich)
+ 9 AuthorsEugen J. Schoenle40
Estimated H-index: 40
(Boston Children's Hospital)
Low-grade inflammation in adipose tissue and liver has been implicated in obesity-associated insulin resistance and type 2 diabetes. Yet, the contribution of inflammatory cells to the pathogenesis of skeletal muscle insulin resistance remains elusive. In a large cohort of obese human individuals, blood monocyte Fas (CD95) expression correlated with systemic and skeletal muscle insulin resistance. To test a causal role for myeloid cell Fas expression in the development of skeletal muscle insulin ...
1234567