Maria C. Rodriguez-Oroz
Publications 93
#1Angelo AntoniniH-Index: 70
#2Daniela BergH-Index: 65
Last.James B. Rowe (University of Cambridge)H-Index: 57
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Abstract Introduction Therapeutic strategies targeting protein aggregations are ready for clinical trials in atypical parkinsonian disorders. Therefore, there is an urgent need for neuroimaging biomarkers to help with the early detection of neurodegenerative processes, the early differentiation of the underlying pathology, and the objective assessment of disease progression. However, there currently is not yet a consensus in the field on how to describe utility of biomarkers for clinical trials ...
1 CitationsSource
Last.Maria C. Rodriguez-OrozH-Index: 33
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Universidad de Malaga. Campus de Excelencia Internacional Andalucia Tech. DFG11/019, PI11/02109
Purpose Previous studies in patients with Parkinson’s disease (PD) and impulse control disorders (ICDs) have produced heterogeneous results regarding striatal dopamine transporter (DaT) binding and activity in the mesocorticolimbic network. Our aim here was to study the relationship between striatal DaT availability and cortical metabolism, as well as motor, behavioural and cognitive features of PD patients with ICD.
1 CitationsSource
#2Belén GagoH-Index: 12
Last.Maria C. Rodriguez-OrozH-Index: 33
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Abstract Treatment with dopaminergic agonists such as pramipexole (PPX) contributes to the development of impulse control disorders (ICDs) in patients with Parkinson's disease (PD). As such, animal models of abnormal impulse control in PD are needed to better study the pathophysiology of these behaviors. Thus, we investigated impulsivity and related behaviors using the 5-choice serial reaction time task, as well as FosB/ΔFosB expression, in rats with mild parkinsonism induced by viral-mediated s...
1 CitationsSource
#1Carmen Gasca-Salas (University of Navarra)H-Index: 5
#2Daniel García-Lorenzo (University of Paris)H-Index: 19
Last.Maria C. Rodriguez-OrozH-Index: 33
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Mild cognitive impairment (MCI) in Parkinson’s disease (PD) is a risk factor for dementia and thus, it is of interest to elucidate if specific patterns of atrophy in PD-MCI patients are associated with a higher risk of developing dementia. We aim to define pattern(s) of regional atrophy in PD-MCI patients who developed dementia during 31 months of follow-up using cortical thickness analysis Twenty-three PD-MCI patients and 18 controls underwent brain MRI and completed a neuropsychological examin...
5 CitationsSource
#1Alejandra Valderrama-Carvajal (UMA: University of Málaga)H-Index: 3
#2Haritz Irizar (UCL: University College London)H-Index: 1
Last.Alicia Rivera (UMA: University of Málaga)H-Index: 29
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Morphine binding to opioid receptors, mainly to μ opioid receptor (MOR), induces alterations in intracellular pathways essential to the initial development of addiction. The activation of the dopamine D4 receptor (D4R), which is expressed in the caudate putamen (CPu), mainly counteracts morphine-induced alterations in several molecular networks. These involve transcription factors, adaptive changes of MOR signaling, activation of the nigrostriatal dopamine pathway and behavioural effects, underl...
1 CitationsSource
#1Jeroen HooglandH-Index: 4
Last.Daniel Weintraub (UPenn: University of Pennsylvania)H-Index: 62
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© 2018 International Parkinson and Movement Disorder Society Background: Numerous neuropsychological tests and test versions are used in Parkinson's disease research, but their relative capacity to detect mild cognitive deficits and their comparability across studies are unknown. The objective of this study was to identify neuropsychological tests that consistently detect cognitive decline in PD across studies. Methods: Data from 30 normed neuropsychological tests across 20 international studies...
5 CitationsSource
2 CitationsSource
#1Monica Diez-Fairen (ISCIII: Instituto de Salud Carlos III)H-Index: 2
#2Bruno A. Benitez (WashU: Washington University in St. Louis)H-Index: 18
Last.Pau Pastor (ISCIII: Instituto de Salud Carlos III)H-Index: 38
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Abstract Eighteen loci and several susceptibility genes have been related to Parkinson's disease (PD). However, most studies focus on single genes in small PD series. Our aim was to establish the genetic background of a large Spanish PD sample. Pooled-DNA target sequencing of 7 major PD genes (SNCA, PARK2, PINK1, DJ-1, LRRK2, GBA, and MAPT) was performed in 562 PD cases. Forty-four variants were found among 114 individuals (20.28%, p
2 CitationsSource
#1Rafael Rodriguez-Rojas (CEU San Pablo University)H-Index: 4
Last.Jose A. Obeso (CEU San Pablo University)H-Index: 14
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Objective Subthalamotomy is an effective alternative for the treatment of Parkinson’s disease (PD). However, uncertainty about the optimal target location and the possibility of inducing haemichorea-ballism have limited its application. We assessed the correlation between the topography of radiofrequency-based lesions of the subthalamic nucleus (STN) with motor improvement and the emergence of haemichorea-ballism. Methods Sixty-four patients with PD treated with subthalamotomy were evaluated pre...
6 CitationsSource