Nancy Berliner
Brigham and Women's Hospital
Gene expressionMolecular biologyImmunologyMedicineBiology
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Publications 198
#1Paolo Sportoletti (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 21
#2Daphna Nachmani (Harvard University)H-Index: 9
Last. Pier Paolo Piccaluga (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 138
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The NPM1 gene is frequently a target of genetic alteration in hematological tumors, particularly of the myeloid lineage. Complete inactivation of Npm1 in the mouse disrupts primitive hematopoiesis and results in embryonic lethality. Npm1 heterozygosity produces features similar to those of MDS that progress to overt leukemia, and specific point mutations of Npm1 lead to bone marrow failure due to loss of hematopoietic stem cells. However, little is known about NPM1s role in mature, differentiate...
#1Mounica Vallurupalli (Brigham and Women's Hospital)H-Index: 5
#2Jean G. MacFadyen (Brigham and Women's Hospital)H-Index: 39
Last. Paul M. Ridker (Brigham and Women's Hospital)H-Index: 194
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Background: Inflammatory cytokines, such as interleukin (IL)-1beta, alter iron homeostasis and erythropoiesis, resulting in anemia, but whether inhibition of IL-1beta can reverse these effects is unclear. Objective: To determine whether IL-1beta inhibition with canakinumab reduces incident anemia and improves hemoglobin levels among those with prevalent anemia. Design: Exploratory analysis of a randomized controlled trial. ( NCT01327846). Setting: Many clinical sites in 39 cou...
1 CitationsSource
#1Peter Miller (Broad Institute)H-Index: 34
#2Abhishek Niroula (Broad Institute)
Last. Mridul Agrawal (Harvard University)
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Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder of immune system overactivation that occurs as familial and acquired forms.1 HLH is characterized by excessive cytokine production and inflammation, mediated by multiple immune cells including persistently activated macrophages. Familial HLH (FHL) is typically diagnosed in childhood and is often caused by inherited biallelic, deletion, or truncating variants in genes regulating the cytotoxic function of T lymphocytes and nat...
#1Nancy Berliner (Brigham and Women's Hospital)H-Index: 38
#2Laurie H. SehnH-Index: 40
#1Daniel H. Solomon (Brigham and Women's Hospital)H-Index: 84
#2Robert J. Glynn (Brigham and Women's Hospital)H-Index: 124
Last. Nancy Berliner (Brigham and Women's Hospital)H-Index: 38
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Background: Low-dose methotrexate (LD-MTX) is the most commonly used drug for systemic rheumatic diseases worldwide and is the recommended first-line agent for rheumatoid arthritis. Despite extensive clinical use for more than 30 years, few data on adverse event (AE) rates derive from randomized, placebo-controlled trials, where both causality and magnitude of risk can be inferred. Objective: To investigate AE rates, risk, and risk differences comparing LD-MTX versus placebo. Design: Prespecifie...
1 CitationsSource
#1Sarah Nikiforow (Harvard University)H-Index: 18
#2Nancy Berliner (Brigham and Women's Hospital)H-Index: 38
#1Mounica Vallurupalli (Brigham and Women's Hospital)
Last. Nancy Berliner (Brigham and Women's Hospital)H-Index: 38
view all 2 authors...
1 CitationsSource
#2Juan Luiz Coelho-Silva (USP: University of São Paulo)H-Index: 3
Last. Eduardo Magalhães Rego (USP: University of São Paulo)H-Index: 26
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#1César Alexander Ortiz Rojas (USP: University of São Paulo)
#2Diego Antonio Pereira-Martins (USP: University of São Paulo)H-Index: 1
Last. Eduardo Magalhães Rego (USP: University of São Paulo)H-Index: 26
view all 25 authors...