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Ausra S. Lionikiene
University of Aberdeen
FibrinolysisFactor XIIIFibrinMedicinePlatelet
6Publications
4H-index
135Citations
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Publications 6
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#1Joanne L. Mitchell (Aberd.: University of Aberdeen)H-Index: 4
#2Ausra S. Lionikiene (Aberd.: University of Aberdeen)H-Index: 4
Last. Nicola J. Mutch (Aberd.: University of Aberdeen)H-Index: 18
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This work was supported by grants FS/11/2/28579 (N.J.M. & A.S.L) from the British Heart Foundation and by the University of Aberdeen Development Trust (J.L.M. & N.J.M.). P.Y.K is supported by an Early Career Award and New Investigator Fund from the Hamilton Health Sciences. We are grateful to the following students for contributions to the project, Natasha Walker & Thomas Nolan. We also thank both the Microscopy and Histology Core Facility and the Iain Fraser Cytometry Centre at the University o...
10 CitationsSource
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#1Joanne L. MitchellH-Index: 4
Last. Nicola J. MutchH-Index: 8
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#1Claire S. Whyte (Aberd.: University of Aberdeen)H-Index: 6
#2Frauke Swieringa (UM: Maastricht University)H-Index: 13
Last. Nicola J. Mutch (Aberd.: University of Aberdeen)H-Index: 18
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The interaction of plasminogen with platelets and their localization during thrombus formation and fibrinolysis under flow are not defined. Using a novel model of whole blood thrombi, formed under flow, we examine dose-dependent fibrinolysis using fluorescence microscopy. Fibrinolysis was dependent upon flow and the balance between fibrin formation and plasminogen activation, with tissue plasminogen activator-mediated lysis being more efficient than urokinase plasminogen activator-mediated lysis...
41 CitationsSource
#1Joanne L. Mitchell (Aberd.: University of Aberdeen)H-Index: 4
#2Ausra S. Lionikiene (Aberd.: University of Aberdeen)H-Index: 4
Last. Nicola J. Mutch (Aberd.: University of Aberdeen)H-Index: 18
view all 6 authors...
Factor XIII (FXIII) stabilizes thrombi against fibrinolysis by cross-linking α2-antiplasmin (α2AP) to fibrin. Cellular FXIII (FXIII-A) is abundant in platelets, but the extracellular functions of this pool are unclear because it is not released by classical secretion mechanisms. We examined the function of platelet FXIII-A using Chandler model thrombi formed from FXIII-depleted plasma. Platelets stabilized FXIII-depleted thrombi in a transglutaminase-dependent manner. FXIII-A activity on activat...
40 CitationsSource
#1R Engel (University of Leeds)H-Index: 1
#2C M Brain (University of Leeds)H-Index: 1
Last. Nicola J. Mutch (Aberd.: University of Aberdeen)H-Index: 18
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© 2014 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.
31 CitationsSource
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