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Toon Braeye
University of Hasselt
StatisticsOutbreakPublic healthVaccinationMedicine
13Publications
4H-index
63Citations
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Publications 17
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#1Toon BraeyeH-Index: 4
#2Hanne-Dorthe EmborgH-Index: 23
Last. C McGeeH-Index: 2
view all 15 authors...
textabstractBackground: The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public–private collaboration aiming to develop and test a system for rapid benefit-risk monitoring of vaccines using existing healthcare databases in Europe. We estimated vaccine coverage from electronic healthcare databases as part of a fit-for-purpose assessment for vaccine benefit-risk studies. Methods: A retrospective dynamic cohort study was conducted through a distributed netw...
#1Toon Braeye (University of Hasselt)H-Index: 4
#2Hanne-Dorthe Emborg (SSI: Statens Serum Institut)H-Index: 23
Last. C McGee (University of Surrey)H-Index: 1
view all 15 authors...
Abstract Background The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public–private collaboration aiming to develop and test a system for rapid benefit-risk monitoring of vaccines using existing healthcare databases in Europe. We estimated vaccine coverage from electronic healthcare databases as part of a fit-for-purpose assessment for vaccine benefit-risk studies. Methods A retrospective dynamic cohort study was conducted through a distributed network a...
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#1Miriam Sturkenboom (Katholieke Universiteit Leuven)H-Index: 1
#1Miriam Sturkenboom (Katholieke Universiteit Leuven)H-Index: 3
Last. Rosa GiniH-Index: 20
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Abstract Introduction The public-private ADVANCE consortium (Accelerated development of vaccine benefit-risk collaboration in Europe) aimed to assess if electronic healthcare databases can provide fit-for purpose data for collaborative, distributed studies and monitoring of vaccine coverage, benefits and risks of vaccines. Objective To evaluate if European healthcare databases can be used to estimate vaccine coverage, benefit and/or risk using pertussis-containing vaccines as an example. Methods...
6 CitationsSource
#1Myint Tin Tin Htar (Pfizer)H-Index: 4
#2Maria A. J. de Ridder (Erasmus University Medical Center)H-Index: 27
Last. Miriam Sturkenboom (Katholieke Universiteit Leuven)H-Index: 1
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Abstract The Accelerated Development of VAccine benefit-risk Collaboration in Europe (ADVANCE), a public-private consortium, implemented and tested a distributed network system for the generation of evidence on the benefits-risks of marketed vaccines in Europe. We tested the system by estimating the incidence rate (IR) of pertussis and pertussis-related complications in children vaccinated with acellular (aP) and whole-cell (wP) pertussis vaccine. Data from seven electronic databases from four c...
1 CitationsSource
#1Hanne-Dorthe EmborgH-Index: 23
#2Johnny Kahlert (Aarhus University Hospital)H-Index: 15
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© 2019 Introduction: The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public-private collaboration aiming to develop and test a system for rapid benefit-risk (B/R) monitoring of vaccines, using existing healthcare databases in Europe. The objective of this paper was to assess the feasibility of using electronic healthcare databases to estimate dose-specific acellular pertussis (aP) and whole cell pertussis (wP) vaccine coverage. Methods: Seven electronic...
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#1Toon Braeye (University of Hasselt)H-Index: 4
#2Vincent BauchauH-Index: 8
Last. Kaatje Bollaerts (Katholieke Universiteit Leuven)H-Index: 9
view all 8 authors...
Introduction The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public private collaboration aiming to develop and test a system for rapid benefit-risk (B/R) monitoring of vaccines, using existing electronic healthcare record (eHR) databases in Europe. Part of the data in such sources is missing due to incomplete follow-up hampering the accurate estimation of vaccination coverage. We compared different methods for coverage estimation from eHR databases; na...
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#1Toon Braeye (University of Hasselt)H-Index: 4
#2Sophie QuoilinH-Index: 9
Last. Niel Hens (University of Antwerp)H-Index: 34
view all 3 authors...
Inverse probability weighting (IPW) methods can be used to estimate the total number of cases from the sample collected through sentinel surveillance. Central to these methods are the inverse weights which can be derived in several ways and, in this case, represent the probability that laboratory (lab) sentinel surveillance detects a lab-confirmed case. We compare different weights in a simulation study. Weights are obtained from the proportion of participating labs over all labs. We adjust thes...
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#1Toon BraeyeH-Index: 4
#2Jan Verheagen (Katholieke Universiteit Leuven)H-Index: 1
Last. Niel Hens (University of Antwerp)H-Index: 34
view all 8 authors...
Introduction Surveillance networks are often not exhaustive nor completely complementary. In such situations, capture-recapture methods can be used for incidence estimation. The choice of estimator and their robustness with respect to the homogeneity and independence assumptions are however not well documented. Methods We investigated the performance of five different capture-recapture estimators in a simulation study. Eight different scenarios were used to detect and combine case-information. T...
3 CitationsSource
#1Toon BraeyeH-Index: 4
#2K. De SchrijverH-Index: 1
Last. J. Verhaegen (Catholic University of Leuven)H-Index: 1
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On 6 December 2010 a fire in Hemiksem, Belgium, was extinguished by the fire brigade with both river water and tap water. Local physicians were asked to report all cases of gastroenteritis. We conducted a retrospective cohort study among 1000 randomly selected households. We performed a statistical and geospatial analysis. Human stool samples, tap water and river water were tested for pathogens. Of the 1185 persons living in the 528 responding households, 222 (18·7%) reported symptoms of gastroe...
20 CitationsSource
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