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Simon F. DeMeyer
Catholic University of Leuven
ImmunologyVon Willebrand factorADAMTS13MedicinePlatelet
108Publications
22H-index
1,718Citations
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Publications 101
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#1Sirima Kraisin (Katholieke Universiteit Leuven)H-Index: 1
#2Sebastien Verhenne (Katholieke Universiteit Leuven)H-Index: 6
Last. Simon F. DeMeyer (Katholieke Universiteit Leuven)H-Index: 22
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BACKGROUND: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a lethal complication of severe malaria, characterized by marked pulmonary inflammation. Patient studies have suggested a link between von Willebrand factor (VWF) and malaria severity. OBJECTIVES: To investigate the role of VWF in the pathogenesis of experimental MA-ARDS. METHODS: Plasmodium berghei NK65-E (PbNK65) parasites were injected in Vwf+/+ and Vwf-/- mice. Pathological parameters were assessed following infe...
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#1An-Sofie Schelpe (Katholieke Universiteit Leuven)H-Index: 4
#2Elien Roose (Katholieke Universiteit Leuven)H-Index: 7
Last. Karen Vanhoorelbeke (Katholieke Universiteit Leuven)H-Index: 39
view all 14 authors...
In autoantibody-mediated autoimmune diseases, autoantibody profiling allows patients to be stratified and links autoantibodies with disease severity and outcome. However, in immune-mediated thrombotic thrombocytopenic purpura (iTTP) patients, stratification according to antibody profiles and their clinical relevance has not been fully explored. We aimed to develop a new type of autoantibody profiling assay for iTTP based on the use of anti-idiotypic antibodies. Anti-idiotypic antibodies against ...
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#1Elodie Laridan (Katholieke Universiteit Leuven)H-Index: 2
#2Kimberly Martinod (Katholieke Universiteit Leuven)H-Index: 22
Last. Simon F. DeMeyer (Katholieke Universiteit Leuven)H-Index: 22
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Thrombotic complications are still a major health risk worldwide. Our view on the pathophysiology of thrombosis has significantly changed since the discovery of neutrophil extracellular traps (NETs) and their prothrombotic characteristics. Generated by neutrophils that release their decondensed chromatin as a network of extracellular fibers, NETs promote thrombus formation by serving as a scaffold that activates platelets and coagulation. The thrombogenic involvement of NETs has been described i...
5 CitationsSource
#1An-Sofie Schelpe (Katholieke Universiteit Leuven)H-Index: 4
#2Anastasis Petri (Imperial College London)H-Index: 2
Last. Karen Vanhoorelbeke (Katholieke Universiteit Leuven)H-Index: 39
view all 7 authors...
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#1Elien Roose (Katholieke Universiteit Leuven)H-Index: 7
#2An-Sofie Schelpe (Katholieke Universiteit Leuven)H-Index: 4
Last. Karen Vanhoorelbeke (Katholieke Universiteit Leuven)H-Index: 39
view all 21 authors...
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#1Irina Portier (Katholieke Universiteit Leuven)H-Index: 2
#2Kimberly Martinod (Katholieke Universiteit Leuven)H-Index: 22
Last. Simon F. De Meyer (Katholieke Universiteit Leuven)H-Index: 13
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Abdominal aortic aneurysm (AAA) refers to a localized dilation of the abdominal aorta that exceeds the normal diameter by 50%. AAA pathophysiology is characterized by progressive inflammation, vessel wall destabilization and thrombus formation. Our aim was to investigate the potential involvement of von Willebrand factor (VWF), a thrombo-inflammatory plasma protein, in AAA pathophysiology using a dissection-based and angiotensin II infusion-induced AAA mouse model. AAA formation was induced in b...
1 CitationsSource
#1Mickael QuivigerH-Index: 3
#2Aristeidis Giannakopoulos (University of Patras)H-Index: 2
Last. Daniel SchermanH-Index: 59
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Abstract Many rare monogenic diseases are treated by protein replacement therapy, in which the missing protein is repetitively administered to the patient. However, in several cases, the missing protein is required at a high and sustained level, which renders protein therapy far from being adequate. As an alternative, a gene therapy treatment ensuring a sustained effectiveness would be particularly valuable. Liver is an optimal organ for the secretion and systemic distribution of a therapeutic t...
1 CitationsSource
#1Patrick A. Brouwer (Karolinska University Hospital)H-Index: 20
#2Waleed Brinjikji (Mayo Clinic)H-Index: 39
Last. Simon F. De Meyer (Katholieke Universiteit Leuven)H-Index: 13
view all 3 authors...
: Cerebral ischemic stroke treatment may change significantly now that clots are actually physically removed from the patient using thrombectomy. This allows for an analysis of the content of the clots as well as the correlation of the imaging findings and the clot behavior and morphology. This article illustrates how the interaction of different clots varies in the clinical setting and how analysis of clot composition, as well as the search for new pharmacologic targets, can lead to a better un...
1 CitationsSource
#2Frederik Denorme (Katholieke Universiteit Leuven)H-Index: 10
Last. David A. Lane (Imperial College London)H-Index: 42
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: Essentials ADAMTS13 requires a substrate-induced conformational change to attain full activity in vitro. The efficacy of wild type ADAMTS13 in models of thrombosis/stroke may be enhanced by pre-activation. A pre-activated ADAMTS13 variant exhibits enhanced proteolysis of platelet agglutinates. This ADAMTS13 variant is protective in a murine model of stroke at a lower dose than WT ADAMTS13. SUMMARY: Background ADAMTS-13 circulates in a closed conformation, only achieving full proteolytic activi...
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#1Elien Vermeersch (Katholieke Universiteit Leuven)H-Index: 2
#2Stéphanie Liénart (UCL: Université catholique de Louvain)H-Index: 5
Last. Hans Deckmyn (Katholieke Universiteit Leuven)H-Index: 52
view all 11 authors...
Abstract GARP is a transmembrane protein that presents latent TGF-β1 on the surface of regulatory T cells (Tregs). Neutralizing anti-GARP monoclonal antibodies that prevent the release of active TGF-β1, inhibit the immunosuppressive activity of human Tregs in vivo . In this study, we investigated the contribution of GARP on mouse Tregs to immunosuppression in experimental tumors. Unexpectedly, Foxp3 conditional garp knockout (KO) mice challenged orthotopically with GL261 tumor cells or subcutane...
1 CitationsSource
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