Ka Nader
University College London
Publications 5
#1S. W. Steven Shaw (UCL: University College London)H-Index: 11
#2Sveva Bollini (UCL: University College London)H-Index: 19
Last.Anna L. David (UCL: University College London)H-Index: 30
view all 11 authors...
Long-term engraftment and phenotype correction has been difficult to achieve in humans after in utero stem cell transplantation mainly because of allogeneic rejection. Autologous cells could be obtained during gestation from the amniotic fluid with minimal risk for the fetus and the mother. Using a sheep model, we explored the possibility of using amniotic fluid mesenchymal stem cells (AFMSCs) for autologous in utero stem cell/gene therapy. We collected amniotic fluid (AF) under ultrasound-guide...
55 CitationsSource
#1Vedanta Mehta (UCL: University College London)H-Index: 8
#2Ka Nader (UCL: University College London)H-Index: 3
Last.Anna L. David (UCL: University College London)H-Index: 30
view all 4 authors...
Prenatal gene therapy aims to deliver genes to cells and tissues early in prenatal life, allowing correction of a genetic defect, before long-term tissue damage has occurred. In contrast to postnatal gene therapy, prenatal application can target genes to a large population of dividing stem cells, and the smaller fetal size allows a higher vector-to-target cell ratio to be achieved. Early-gestation delivery may allow the development of immune tolerance to the transgenic protein which would facili...
11 CitationsSource
#2Sveva BolliniH-Index: 19
Last.Anna L. DavidH-Index: 30
view all 10 authors...
#2Sveva BolliniH-Index: 19
Last.Anna L. DavidH-Index: 30
view all 11 authors...
#1Anna L. David (UCL: University College London)H-Index: 30
#2Belen Torondel (UCL: University College London)H-Index: 18
Last.Donald Peebles (UCL: University College London)H-Index: 31
view all 12 authors...
Impaired materno-placental perfusion causes two important obstetric complications, fetal growth restriction and preeclampsia. This study investigated whether adenoviral vector-mediated overexpression of vascular endothelial growth factor (VEGF) in the uterine arteries (UtAs) increases uterine artery blood flow (UBF). First-generation adenovirus vectors (5 X 10(11) particles) containing the VEGF gene (Ad. VEGF-A or-D) or the beta-galactosidase reporter gene (Ad. lacZ) were injected into the UtAs ...
60 CitationsSource