Match!
Thomas Stabler
Duke University
Physical therapyOsteoarthritisSynovial fluidMedicineBiomarker (medicine)
78Publications
28H-index
2,315Citations
What is this?
Publications 78
Newest
#1Ursula Heilmeier (UCSF: University of California, San Francisco)H-Index: 12
#2K. Mamoto (UCSF: University of California, San Francisco)
Last. Xiaojuan Li (UCSF: University of California, San Francisco)H-Index: 2
view all 13 authors...
Summary Objective To evaluate the degree of knee fat pad abnormalities after acute anterior cruciate ligament (ACL) tear via magnetic resonance fat pad scoring and to assess cross-sectionally its association with synovial fluid biomarkers and with early cartilage damage as quantified via T1ρ and T2 relaxation time measurements. Design 26 patients with acute ACL tears underwent 3T MR scanning of the injured knee prior to ACL reconstruction. The presence and degree of abnormalities of the infrapat...
Source
#1K. Amano (UCSF: University of California, San Francisco)H-Index: 7
#2Janet L. Huebner (Duke University)H-Index: 29
Last. Xiaojuan Li (UCSF: University of California, San Francisco)H-Index: 37
view all 10 authors...
Background:Anterior cruciate ligament tears can lead to posttraumatic osteoarthritis. In addition to biomechanical factors, changes in biochemical profiles within the knee joint after injury and anterior cruciate ligament reconstruction (ACLR) may play a role in accelerating joint degeneration.Hypothesis/Purpose:It was hypothesized that cartilage matrix composition after ACLR is associated with the degree of inflammatory response after initial injury. This study evaluated the association between...
16 CitationsSource
#1Thomas Stabler (Duke University)H-Index: 28
#2Eulàlia MontellH-Index: 20
Last. Virginia B. Kraus (Duke University)H-Index: 65
view all 5 authors...
Monocyte chemoattractant protein-1 (MCP-1) overproduction from inflamed adipose tissue is a major contributor to obesity-related metabolic syndromes. 3T3-L1 embryonic fibroblasts were cultured and differentiated into adipocytes using an established protocol. Adipocytes were treated with lipopolysaccharide (LPS) to induce inflammation and thus MCP-1 release. At the same time, varying concentrations of chondroitin sulfate (CS) were added in a physiologically relevant range (10-200 µg/mL) to determ...
3 CitationsSource
#1Eulàlia MontellH-Index: 20
#2Thomas Stabler (Duke University)H-Index: 28
Last. Virginia B. Kraus (Duke University)H-Index: 65
view all 3 authors...
Background Monocyte chemoattractant protein-1 (MCP-1) overproduction from inflamed adipose tissue is a major contributor to obesity-related metabolic syndromes. We have recently published that chondroitin sulphate (CS) can attenuate the monosodium urate (MSU) crystal mediated THP-1 macrophage inflammatory response reflected by reduced release of pro-inflammatory cytokines IL-1β and TNFα. We have also recently determined that the CS inhibitory effect is not acting at the inflammasome but upstream...
Source
#1Ursula Heilmeier (UCSF: University of California, San Francisco)H-Index: 12
#2K. Amano (UCSF: University of California, San Francisco)H-Index: 7
Last. Xiaojuan Li (UCSF: University of California, San Francisco)H-Index: 37
view all 10 authors...
1 CitationsSource
#1Eulàlia MontellH-Index: 20
#2Thomas Stabler (Duke University)H-Index: 28
Last. Virginia B. Kraus (Duke University)H-Index: 65
view all 4 authors...
1 CitationsSource
#1Thomas Stabler (Duke University)H-Index: 28
#2Zeyu Huang (Sichuan University)H-Index: 15
Last. Virginia B. Kraus (Duke University)H-Index: 65
view all 5 authors...
Summary Objective To evaluate the anti-inflammatory mechanism of action of Chondroitin Sulphate (CS). Design THP-1 macrophages were cultured with a range of sizes and concentrations of HA fragments with TLR4 (LPS in a physiologically relevant concentration determined by analyses of sera of a community clinic ascertained knee osteoarthritis (OA) cohort) or TLR2 (heat killed listeria bacteria) agonists and varying concentrations of CS in a physiologically relevant range (10–200 μg/ml). We measured...
22 CitationsSource
#1Zeyu Huang (Sichuan University)H-Index: 15
#2Thomas Stabler (Duke University)H-Index: 28
Last. Virginia B. Kraus (Duke University)H-Index: 65
view all 4 authors...
Summary Objective The microbiome is recognized as a new frontier in medicine with connections to a variety of diseases. We aimed to evaluate the association of lipopolysaccharide (LPS), a key pro-inflammatory product of the microbiome, with severity of inflammation, symptoms and radiographic abnormalities of knee osteoarthritis (OA). Design LPS was measured using a recombinant Factor C (rFC) assay, carefully optimized for systemic and synovial fluid (SF) analyses. LPS binding protein (LBP) was t...
48 CitationsSource
Source
Source
12345678