Ron Wald
International Council for the Exploration of the Sea
Publications 200
Abstract Purpose Severe acute kidney injury (AKI) is associated with a significant risk of mortality and persistent renal replacement therapy (RRT) dependence. The objective of this study was to develop prediction models for mortality at 90-day and 1-year following RRT initiation in critically ill patients with AKI. Methods All patients who commenced RRT in the intensive care unit for AKI at a tertiary care hospital between 2007 and 2014 constituted the development cohort. We evaluated the exter...
Background Conversion from conventional hemodialysis (CHD) to in-centre nocturnal hemodialysis (INHD) is associated with left ventricular (LV) mass regression, but the underlying mechanisms are not fully understood. Using cardiac MRI (CMR), we examined the effects of INHD on epicardial adipose tissue (EAT) and paracardial adipose tissue (PAT), and the relationships between EAT, PAT and LV remodeling, biomarkers of nutrition, myocardial injury, fibrosis and volume.
Abstract Background Studies have shown that achieving a time in therapeutic range (TTR) for warfarin of greater than 60% is associated with a lower risk of bleeding. However, many patients on hemodialysis (HD) do not achieve this target. Local Problem We audited TTR achievement at the in-center HD unit of our hospital in 2017 and found that only 40% of patients had achieved a TTR>60%. Project Aims We aimed to improve the percentage of HD patients achieving target TTR within two years. Interventi...
Rationale & Objective Surveillance blood work is routinely performed in maintenance hemodialysis (HD) recipients. Although more frequent blood testing may confer better outcomes, there is little evidence to support any particular monitoring interval. Study Design Retrospective population-based cohort study. Setting & Participants All prevalent HD recipients in Ontario, Canada, as of April 1, 2011, and a cohort of incident patients commencing maintenance HD in Ontario, Canada, between April 1, 20...
#1Chirag R. ParikhH-Index: 67
#2Jason H. Greenberg (Yale University)H-Index: 7
Last.Amit X. Garg (UWO: University of Western Ontario)H-Index: 81
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Background and objectives Survival after surgical repair for congenital heart disease has markedly improved; however, there are limited data on long-term ESKD and mortality during childhood. Design, setting, participants, & measurements We conducted an observational, population-based cohort study of children who had their first surgery for congenital heart disease within 10 years of birth. The study was conducted in Ontario, Canada, where residents have universal access to health care services. ...
#1Adrianna Douvris (U of O: University of Ottawa)H-Index: 2
#2Khalid Zeid (U of O: University of Ottawa)H-Index: 1
Last.Edward G. Clark (U of O: University of Ottawa)H-Index: 12
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Hemodynamic instability related to renal replacement therapy (HIRRT) is a frequent complication of all renal replacement therapy (RRT) modalities commonly used in the intensive care unit. HIRRT is associated with increased mortality and may impair kidney recovery. Our current understanding of the physiologic basis for HIRRT comes primarily from studies of end-stage kidney disease patients on maintenance hemodialysis in whom HIRRT is referred to as ‘intradialytic hypotension’. Nonetheless, there ...
2 CitationsSource
#1William Beaubien-Souligny (UdeM: Université de Montréal)
#2Loay Kontar (MHI: Montreal Heart Institute)
Last.Ron Wald (U of T: University of Toronto)H-Index: 44
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Introduction Technological adjuncts have been developed to improve the accuracy of fluid removal goals in maintenance dialysis recipients. We aimed to determine whether the introduction of these tools has been shown to impact clinical outcomes. Methods We performed a systematic review and meta-analysis of randomized controlled trials that compared fluid management guided by technological adjuncts to standard care in hemodialysis and peritoneal dialysis. The primary outcome was all-cause mortalit...
#1Rahul Chanchlani (McMaster-Carr)
#2Danielle M. Nash (International Council for the Exploration of the Sea)H-Index: 11
Last.Ron Wald (St. Michael's Hospital)H-Index: 44
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Background and objectives There is a limited appreciation of the epidemiology of dialysis-receiving AKI in children. The primary objective of the study was to evaluate changes in the incidence of dialysis-receiving AKI among children over a period of 20 years in Ontario, Canada. The secondary objectives were to assess temporal trends in the utilization of various dialysis modalities and 30-day mortality among children with dialysis-receiving AKI. Design, setting, participants, & measurements All...
#2Ron Wald (U of T: University of Toronto)H-Index: 44
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#1Oleksa G. Rewa (U of A: University of Alberta)H-Index: 8
#2Sean M. Bagshaw (U of A: University of Alberta)H-Index: 61
Last.Jay L. Koyner (U of C: University of Chicago)H-Index: 31
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Abstract Purpose To validate the furosemide stress test (FST) for predicting the progression of acute kidney injury (AKI). Materials and methods We performed a multicenter, prospective, observational study in patients with stage I or II AKI. The FST (1 mg/kg for loop diuretic naive patients and 1.5 mg/kg in patients previously exposed to loop diuretics) was administered. Subsequent urinary flow rate (UFR) recorded and predictive ability of urinary output was measured by the area under the curve ...