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Małgorzata Latocha
Medical University of Silesia
70Publications
11H-index
485Citations
Publications 70
Newest
#1Małgorzata Jeleń (Medical University of Silesia)H-Index: 11
#2Krystian Pluta (Medical University of Silesia)H-Index: 15
Last.Dariusz Kuśmierz (Medical University of Silesia)H-Index: 4
view all 6 authors...
Abstract We present efficient synthesis of isomeric types of angularly fused diquinothiazines in the reactions of 2,2′-dichloro-3,3′-diquinolinyl disulfide and diquinodithiin with 3-, 5-, 6- and 8-aminoquinolines. The pentacyclic diquinothiazine ring systems were identified as diquino[3,2-b;3′,4′-e][1,4]thiazine, diquino[3,2-b;5′,6′-e][1,4]thiazine, diquino[3,2-b;6′,5′-e][1,4]thiazine and diquino[3,2-b;8′,7′-e][1,4]thiazine with advanced two-dimensional 1H and 13C NMR techniques (COSY, ROESY, HS...
#1Katarzyna Jelonek (PAN: Polish Academy of Sciences)H-Index: 8
#2Alicja Zajdel (Medical University of Silesia)H-Index: 9
Last.Janusz Kasperczyk (PAN: Polish Academy of Sciences)H-Index: 29
view all 7 authors...
Abstract Polymeric micelles have been widely studied and developed for targeted delivery of cytostatic drugs. However, due to heterogeneity of tumor cells, targeting efficiency may be enhanced by using different types of targeting agents on the same drug delivery system. The aim of the study was to obtain and characterize paclitaxel-loaded biodegradable poly( l -lactide)-co-poly(ethylene glycol) (PLA-PEG) micelles functionalized with folic acid and biotin. The developed dual targeted micelles sh...
#2Krystian PlutaH-Index: 15
Last.Dariusz KuśmierzH-Index: 4
view all 5 authors...
New 10-substituted derivatives of 3,6-diazaphenothiazine, containing the triple bond linker terminated with tertiary cyclic and acyclic amine groups, were synthesized and screened for their anticancer action. The compounds exhibited varied anticancer activities against human glioblastoma SNB-19, melanoma C-32, and breast cancer MDA-MB231 cell lines, depending on the nature of the substituents. The most active 3,6-diazaphenothiazine, 4, was the derivative with the N,N-diethylamino-2-butynyl subst...
#1Beata Morak-Młodawska (Medical University of Silesia)H-Index: 13
#2Krystian Pluta (Medical University of Silesia)H-Index: 15
Last.Jurzak M (Medical University of Silesia)H-Index: 6
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Abstract10H-1,9-diazaphenothiazine was obtained in the sulphurisation reaction of diphenylamine with elemental sulphur and transformed into new 10-substituted derivatives, containing alkyl and dial...
#1Alicja Kowalska (Medical University of Silesia)H-Index: 3
#2Krystian Pluta (Medical University of Silesia)H-Index: 15
Last.Małgorzata Latocha (Medical University of Silesia)H-Index: 11
view all 3 authors...
A synthesis of new 2,6-disubstituted and 2,6,8-trisubstituted 7-methylpurines as well as 8-substituted 3,7-dimethylxanthines containing a triple bond chain have been worked out. Purinethiones and xanthinethiones were converted into propynylthio derivatives, which were then further transformed via a Mannich reaction into aminobutynylthio derivatives (amine = pyrrolidine, piperidine, morpholine, and diethylamine). The products thus obtained represent various types of the purine and xanthine struct...
#1Krzysztof Marciniec (Medical University of Silesia)H-Index: 7
#2Bartosz Pawełczak (Medical University of Silesia)H-Index: 3
Last.Stanisław Boryczka (Medical University of Silesia)H-Index: 11
view all 7 authors...
ABSTRACTThe complex formation of bovine serum albumin (BSA) with library of all seven regioisomeric quinolinesulfonamides (QSAs) under physiological condition is studied in this paper. The fluorescence quenching mechanism of BSA by QSAs was discussed and the association constants, as well as the number of binding sites, were calculated. In addition, a molecular docking study of the tested sulfamoylquinolines on the active site of serum albumin is performed. The experimental data and molecular do...
#1Ewa BębenekH-Index: 7
#2Maria JastrzebskaH-Index: 10
Last.Stanisław BoryczkaH-Index: 11
view all 10 authors...
Betulin derivatives containing a 1,2,3-triazole ring possess a wide spectrum of biological activities, including antiviral, anticancer, and antibacterial activity. A series of novel triazoles were prepared by the 1,3-dipolar cycloaddition reaction between the alkyne derivatives of betulin and organic azides. The chemical structures of the obtained compounds were defined by 1H and 13C NMR, IR, and high-resolution mass spectrometry (HR-MS) analysis. The target triazoles were screened for their ant...
#1Krzysztof Marciniec (Medical University of Silesia)H-Index: 7
#2Małgorzata Latocha (Medical University of Silesia)H-Index: 11
Last.Stanisław Boryczka (Medical University of Silesia)H-Index: 11
view all 4 authors...
A small library of methylthio- or methylseleno-quinolyl-linked 1,4-disubstituted 1,2,3-triazole conjugates has been synthesized from the halogenopropargylthio- or halogenopropargylseleno-quinolines through one-pot click reaction. The ability of all of the synthesized compounds to inhibit the proliferation of the C-32, T-47D, and SNB-19 cell lines was determined using the WST-1 assay. The cytotoxic properties of these new, modified derivatives of quinolyl-triazoles were comparable to those of cis...
#2Ewa BębenekH-Index: 7
Last.Stanisław BoryczkaH-Index: 11
view all 5 authors...
The compounds produced by a living organism are most commonly as medicinal agents and starting materials for the preparation of new semi-synthetic derivatives. One of the largest groups of natural compounds consists of products containing a 1,4-benzoquinone subunit. This fragment occurs in three enediyne antibiotics, dynemicin A, deoxydynemicin A, and uncilamicin, which exhibit high biological activity. A series of alkoxy derivatives containing 1,4-naphthoquinone, 5,8-quinolinedione, and 2-methy...
#2Bartosz PawełczakH-Index: 3
Last.Stanisław BoryczkaH-Index: 11
view all 6 authors...
In this study, a series of regioisomeric acetylenic sulfamoylquinolines are designed, synthesized, and tested in vitro for their antiproliferative activity against three human breast cacer cell lines (T47D, MCF-7, and MDA-MB-231) and a human normal fibroblast (HFF-1) by 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST-1) assay. The antiproliferative activity of the tested acetylenic quinolinesulfonamides is comparable to that of cisplatin. The bioassay results ...
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