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Ghulam Ilyas
Albert Einstein College of Medicine
Proinflammatory cytokineAutophagyLiver injuryInflammationATG5
3Publications
3H-index
177Citations
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Publications 3
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#1Gadi Lalazar (Albert Einstein College of Medicine)H-Index: 9
#2Ghulam Ilyas (Albert Einstein College of Medicine)H-Index: 3
Last. Mark J. Czaja (Albert Einstein College of Medicine)H-Index: 5
view all 9 authors...
Autophagy is required for hepatocytes to resist injury from high concentrations of LPS. With a genetic decrease in hepatocyte autophagy, increased liver injury occurred in response to LPS from sensitization to TNF-dependent hepatocellular death in association with an impairment in Akt signaling. Human conditions such as aging and hepatic steatosis may worsen the clinical outcome from sepsis as the result of their concomitant decrease in hepatic levels of autophagy.
15 CitationsSource
#1Ghulam Ilyas (Albert Einstein College of Medicine)H-Index: 3
#2Enpeng Zhao (Albert Einstein College of Medicine)H-Index: 8
Last. Mark J. Czaja (Albert Einstein College of Medicine)H-Index: 47
view all 7 authors...
Background & Aims Overactivation of the innate immune response underlies many forms of liver injury including that caused by hepatotoxins. Recent studies have demonstrated that macrophage autophagy regulates innate immunity and resultant tissue inflammation. Although hepatocyte autophagy has been shown to modulate hepatic injury, little is known about the role of autophagy in hepatic macrophages during the inflammatory response to acute toxic liver injury. Our aim therefore was to determine whet...
42 CitationsSource
#1Kun Liu (Albert Einstein College of Medicine)H-Index: 4
#2Enpeng Zhao (Albert Einstein College of Medicine)H-Index: 8
Last. Mark J. Czaja (Albert Einstein College of Medicine)H-Index: 47
view all 8 authors...
Recent evidence that excessive lipid accumulation can decrease cellular levels of autophagy and that autophagy regulates immune responsiveness suggested that impaired macrophage autophagy may promote the increased innate immune activation that underlies obesity. Primary bone marrow-derived macrophages (BMDM) and peritoneal macrophages from high-fat diet (HFD)-fed mice had decreased levels of autophagic flux indicating a generalized impairment of macrophage autophagy in obese mice. To assess the ...
120 CitationsSource
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