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Fani-Marlen Roumelioti
Academy of Athens
6Publications
4H-index
187Citations
Publications 6
Newest
#1Fani-Marlen Roumelioti (Academy of Athens)H-Index: 4
Last.Sarantis Gagos (Academy of Athens)H-Index: 16
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Purpose Male carriers of an X-autosome translocation are generally infertile, regardless of the position of the breakpoint on the X chromosome while the pathogenicity of Xp22.3 subtelomeric duplications is under debate. To shed light into this controversy, we present a rare case, of an azoospermic male with no other significant clinical findings, in whom classical cytogenetics revealed additional unbalanced chromosomal material, at the telomere of the long arm of one homolog of chromosome 9.
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#1Eirini-Stavroula Komseli (UoA: National and Kapodistrian University of Athens)H-Index: 3
#2Ioannis S. Pateras (UoA: National and Kapodistrian University of Athens)H-Index: 19
Last.Vassilis G. Gorgoulis (UoA: National and Kapodistrian University of Athens)H-Index: 47
view all 21 authors...
Senescence is a fundamental biological process implicated in various pathologies, including cancer. Regarding carcinogenesis, senescence signifies, at least in its initial phases, an anti-tumor response that needs to be circumvented for cancer to progress. Micro-RNAs, a subclass of regulatory, non-coding RNAs, participate in senescence regulation. At the subcellular level micro-RNAs, similar to proteins, have been shown to traffic between organelles influencing cellular behavior. The differentia...
8 CitationsSource
#1Athel Cornish-Bowden (CNRS: Centre national de la recherche scientifique)H-Index: 40
#2David RasnickH-Index: 14
Last.Michelle A. Digman (UCI: University of California, Irvine)H-Index: 39
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Source
#1Fani-Marlen Roumelioti (Academy of Athens)H-Index: 4
#2Sotirios K. Sotiriou (University of Geneva)H-Index: 7
Last.Sarantis Gagos (Academy of Athens)H-Index: 16
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Human malignancies overcome replicative senescence either by activating the reverse‐transcriptase telomerase or by utilizing a homologous recombination‐based mechanism, referred to as alternative lengthening of telomeres (ALT). In budding yeast, ALT exhibits features of break‐induced replication (BIR), a repair pathway for one‐ended DNA double‐strand breaks (DSBs) that requires the non‐essential subunit Pol32 of DNA polymerase delta and leads to conservative DNA replication. Here, we examined wh...
44 CitationsSource
#1Panagiotis Galanos (UoA: National and Kapodistrian University of Athens)H-Index: 4
#2Konstantinos Vougas (Academy of Athens)H-Index: 19
Last.Vassilis G. Gorgoulis (UoA: National and Kapodistrian University of Athens)H-Index: 47
view all 27 authors...
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could also be oncogenic, through a mechanism that has so far remained obscure. We report that a subset of atypical cancerous cells strongly expressing p21 showed proliferation features. This occurred predominantly in p53-mutant human cancers, suggesting p53-independent upregulation of p21 selectively in more aggressive tumour ce...
97 CitationsSource
#1Paulina Marzec (French Institute of Health and Medical Research)H-Index: 1
#2Claudia Armenise (French Institute of Health and Medical Research)H-Index: 1
Last.Jérôme Déjardin (French Institute of Health and Medical Research)H-Index: 15
view all 8 authors...
Summary The breakage-fusion-bridge cycle is a classical mechanism of telomere-driven genome instability in which dysfunctional telomeres are fused to other chromosomal extremities, creating dicentric chromosomes that eventually break at mitosis. Here, we uncover a distinct pathway of telomere-driven genome instability, specifically occurring in cells that maintain telomeres with the alternative lengthening of telomeres mechanism. We show that, in these cells, telomeric DNA is added to multiple d...
38 CitationsSource
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