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Edith Tzeng
University of Pittsburgh
165Publications
38H-index
5,348Citations
Publications 160
Newest
#1Andrew E. Leake (University of Pittsburgh)H-Index: 5
#2Karim M. Salem (University of Pittsburgh)H-Index: 1
Last.Edith Tzeng (University of Pittsburgh)H-Index: 38
view all 8 authors...
Abstract Carbon monoxide (CO) is anti-inflammatory and protective in models of disease. Its actions in vitro are short-lived but are sustained in vivo. We hypothesize that systemic CO can mediate prolonged phenotype changes in vivo, with a focus on macrophages (Mϕs). Mϕs isolated from CO treated rats responded to lipopolysaccharide (LPS) with increased IL6, IL10 and iNOS expression but decreased TNF. Conditioned media (CM) collected from peritoneal Mϕs isolated from CO treated rats stimulated en...
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Background While the perioperative stroke rate after carotid endarterectomy (CEA) is low, “silent” microinfarctions identified by magnetic resonance imaging (MRI) are common and have been correlated with postoperative neurocognitive decline. Our study will investigate the role of remote ischemic preconditioning (RIPC) as a potential neuroprotective mechanism. RIPC is a well-tolerated stimulus that, through neuronal and humoral pathways, generates a systemic environment of greater resistance to s...
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#1Katherine M. Reitz (University of Pittsburgh)H-Index: 2
#2Nathan L. Liang (University of Pittsburgh)H-Index: 7
Last.Edith Tzeng (University of Pittsburgh)H-Index: 38
view all 5 authors...
Abstract Background The durability of endovascular aneurysm repair (EVAR) when compared to open surgical repair (OSR) in younger patients for elective, infrarenal abdominal aortic aneurysms (AAA) remains unclear due to limited follow up. Study Design We identified all patients Results We identified 253 patients. 204 underwent EVAR (80.6%) and 49 OSR (19.4%). Baseline demographcis and comorbidities were similar across groups. There were no deaths in the immediate perioperative period. The rate of...
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#1Peter B. Anderson (Dartmouth College)H-Index: 1
#2Zachary J. WankenH-Index: 1
Last.Philip P. GoodneyH-Index: 42
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Abstract Objective Shared medical decision making is most important when there are competing options for repair such as in treatment of abdominal aortic aneurysm (AAA). We sought to understand the sources of patients' pre-existing knowledge about AAA to better inform treating physicians about patients' needs for preoperative counseling. Methods We performed a multicenter survey of patients facing AAA repair at 20 Veterans Affairs hospitals across the United States as part of the Preferences for ...
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Abstract For patients with abdominal aortic aneurysm, randomized trials have found endovascular AAA repair (EVAR) is associated with lower perioperative morbidity and mortality than open surgical repair (OSR). However, OSR has fewer long-term aneurysm-related complications such as endoleak or late rupture. Patients treated with EVAR and OSR have similar survival rates within two years following surgery, and OSR does not require intensive surveillance. Few have examined if patient preferences are...
1 CitationsSource
#1Luka Pocivavsek (U of C: University of Chicago)H-Index: 9
#2Sang-Ho Ye (University of Pittsburgh)H-Index: 11
Last.William R. Wagner (University of Pittsburgh)H-Index: 56
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Abstract The inner surfaces of arteries and veins are naturally anti-thrombogenic, whereas synthetic materials placed in blood contact commonly experience thrombotic deposition that can lead to device failure or clinical complications. Presented here is a bioinspired strategy for self-cleaning anti-thrombotic surfaces using actuating surface topography. As a first test, wrinkled polydimethylsiloxane planar surfaces are constructed that can repeatedly transition between smooth and wrinkled states...
1 CitationsSource
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#1Luka Pocivavsek (University of Pittsburgh)H-Index: 4
#2Joseph Pugar (University of Pittsburgh)H-Index: 1
Last.Enrique Cerda (Usach: University of Santiago, Chile)H-Index: 15
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Natural surfaces excel in self-renewal and preventing bio-fouling, while synthetic materials placed in contact with complex fluids quickly foul1,2. We present a novel biophysics-inspired mechanism3,4 for surface renewal using actuating surface topography, generated by wrinkling. We calculate a critical surface curvature, given by an intrinsic characteristic length scale of the fouling layer that accounts for its effective flexural or bending stiffness and adhesion energy, beyond which surface re...
7 CitationsSource
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