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Karine R. Sahakyan
Mayo Clinic
12Publications
7H-index
354Citations
Publications 12
Newest
#1Elizabeth Vásquez (University at Albany, SUNY)H-Index: 4
#2Elizabeth Vasquez (University at Albany, SUNY)H-Index: 6
Last.Benjamin A. Shaw (University at Albany, SUNY)H-Index: 24
view all 6 authors...
ABSTRACTAims: This study sought to determine whether the association between varying levels of physical activity (PA) and all-cause and cardiovascular mortality differ by race/ethnicity in older adults.Methods: The sample comprised 2520 women and 2398 men drawn from National Health and Nutrition Examination Survey III (1988–1994) aged ≥ 60 years. We used the metabolic equivalent (MET) of self-reported PA levels to define activity groups (inactive: those who did not report any PA; active: those w...
#1John A. BatsisH-Index: 26
#2Todd A. MacKenzie (Dartmouth College)H-Index: 33
Last.Francisco Lopez-JimenezH-Index: 51
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Diagnostic accuracy of body mass index to identify obesity in older adults: NHANES 1999–2004
#1Prachi SinghH-Index: 15
#2Pragya Sharma (Mayo Clinic)H-Index: 2
Last.Tomáš Kára (Mayo Clinic)H-Index: 24
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Adiponectin exerts beneficial effects by reducing inflammation and improving lipid metabolism and insulin sensitivity. Although the adiponectin level is lower in obese individuals, whether weight gain reduces adiponectin expression in humans is controversial. We sought to investigate the role of weight gain, and consequent changes in leptin, on altering adiponectin expression in humans.Forty-four normal-weight healthy subjects were recruited (mean age 29 years; 14 women) and randomized to either...
#1Karine R. Sahakyan (Mayo Clinic)H-Index: 7
#2Virend K. SomersH-Index: 96
Last.Prachi SinghH-Index: 15
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Background The relation between central obesity and survival in community-dwelling adults with a normal body mass index (BMI) is not well known.
#1Tomas Konecny (Mayo Clinic)H-Index: 14
#2Jeffrey B. Geske (Mayo Clinic)H-Index: 16
Last.Karine R. Sahakyan (Mayo Clinic)H-Index: 7
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BACKGROUND Mechanisms of decreased exercise capacity in patients with hypertrophic cardiomyopathy (HCM) are not well understood. Sleep-disordered breathing (SDB) is a highly prevalent but treatable disorder in patients with HCM. The role of comorbid SDB in the attenuated exercise capacity in HCM has not been studied previously. METHODS Overnight oximetry, cardiopulmonary exercise testing, and echocardiographic studies were performed in consecutive patients with HCM seen at the Mayo Clinic. SDB w...
#1John A. Batsis (Dartmouth College)H-Index: 26
#2Karine R. Sahakyan (Mayo Clinic)H-Index: 7
Last.Francisco Lopez-Jimenez (Mayo Clinic)H-Index: 51
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Abstract Objective To determine whether leptin is related to all-cause and cardiovascular (CV) mortality in older adults. Patients and Methods Participants 60 years and older with plasma leptin level measurements from the National Health and Nutrition Examination Survey III (1988-1994) and mortality data linked to the National Death Index were included. We created sex-specific tertiles of leptin (men: 4.2-7.7 μg/L; women: 11.5-21.4 μg/L) to identify the effect of leptin on all-cause and CV morta...
#1Naima Covassin (Mayo Clinic)H-Index: 10
#2Jan Bukartyk (Mayo Clinic)H-Index: 10
Last.Virend K. Somers (Mayo Clinic)H-Index: 96
view all 7 authors...
Although growing evidence suggests that insufficient sleep is linked to enhanced risk of adverse events including hypertension, mechanistic investigations supporting causal relationships are lacking. In this study we sought to evaluate changes in ambulatory blood pressure in healthy individuals
#1John A. Batsis (Dartmouth College)H-Index: 26
#2Karine R. Sahakyan (Mayo Clinic)H-Index: 7
Last.Francisco Lopez-Jimenez (Mayo Clinic)H-Index: 51
view all 5 authors...
Abstract Background Obesity defined by body mass index (BMI) is associated with higher levels of functional impairment. However, BMI strata misrepresent true adiposity, particularly in those with a normal BMI but elevated body fat (BF%) (normal weight obesity [NWO]) whom are at higher metabolic and mortality risk. Whether this subset of patients is associated with worsening functional outcomes is unclear. Methods Subjects aged ≥ 60 years with a BMI ≥ 18.5 kg/m 2 from NHANES III (1988–1994) were ...
#1John A. Batsis (Dartmouth College)H-Index: 26
#2Karine R. Sahakyan (Mayo Clinic)H-Index: 7
Last.Francisco Lopez-Jimenez (Mayo Clinic)H-Index: 51
view all 6 authors...
Current body mass index (BMI) strata likely misrepresent the accuracy of true adiposity in older adults. Subjects with normal BMI with elevated body fat may metabolically have higher cardiovascular and overall mortality than previously suspected. We identified 4,489 subjects aged ≥60 years (BMI = 18.5 to 25 kg/m 2 ) with anthropometric and bioelectrical impedance measurements from the National Health and Nutrition Examination Surveys III (1988 to 1994) and mortality data linked to the National D...
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