Donna Neuberg
Harvard University
CancerImmunologyCancer researchMedicineBiology
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Publications 899
#1Brian J. Carney (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
#2Erik J. Uhlmann (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 22
Last. Jeffrey I. Zwicker (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 25
view all 7 authors...
#1Tarek H. Mouhieddine (Broad Institute)H-Index: 9
#2Adam S. Sperling (Harvard University)H-Index: 6
Last. Daisy Huynh (Harvard University)H-Index: 14
view all 38 authors...
Multiple myeloma (MM) is a plasma-cell neoplasm that is treated with high-dose chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. The presence of somatic mutations in the peripheral blood is termed clonal hematopoiesis of indeterminate potential (CHIP) and is associated with adverse outcomes. Targeted sequencing of the stem cell product from 629 MM patients treated by ASCT at the Dana-Farber Cancer Institute (2003–2011) detects CHIP in 13...
2 CitationsSource
#1David A. Braun (Broad Institute)H-Index: 10
#2Yue Hou (Harvard University)
Last. Liudmilla Elagina (Broad Institute)
view all 26 authors...
PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors from patients with advanced ccRCC enrolled in prospective clinical trials of treatment with PD-1 blockade by whole-exome and RNA sequencing, integrated with immunofluorescence analysis, to uncover the immunogenomic determinants of the therapeutic response. Although conventional genomic mar...
#1Jeffrey I. Zwicker (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 25
#2Joanna Roopkumar (Cleveland Clinic)H-Index: 2
Last. Kenneth A. Bauer (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 70
view all 11 authors...
: Hospitalized patients with cancer are at an increased risk of developing venous thromboembolism (VTE). The recommendation for routine pharmacologic thromboprophylaxis in hospitalized patients with cancer to prevent VTE is based on extrapolation of results from noncancer cohorts. There are limited data to support the efficacy and safety of fixed-dose low-molecular-weight heparin (LMWH) regimens in high-risk hospitalized patients with cancer. We conducted a randomized, double-blinded, phase 2 tr...
#1David A. Braun (Harvard University)H-Index: 10
#2Yue Hou (Harvard University)
Last. Jean-Christophe Pignon (Brigham and Women's Hospital)H-Index: 7
view all 20 authors...
#1Guray Akturk (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
#2Edwin Roger Parra Cuentas (University of Texas MD Anderson Cancer Center)H-Index: 5
Last. Jiexin Zhang (University of Texas MD Anderson Cancer Center)H-Index: 31
view all 14 authors...
#1Huan Chen (Harvard University)H-Index: 1
#2Yuxiang Zhang (Harvard University)H-Index: 13
Last. Donna Neuberg (Harvard University)H-Index: 120
view all 12 authors...
The antigen-binding variable regions of the B cell receptor (BCR) and of antibodies are encoded by exons that are assembled in developing B cells by V(D)J recombination1. The BCR repertoires of primary B cells are vast owing to mechanisms that create diversity at the junctions of V(D)J gene segments that contribute to complementarity-determining region 3 (CDR3), the region that binds antigen1. Primary B cells undergo antigen-driven BCR affinity maturation through somatic hypermutation and cellul...
1 CitationsSource
#1Vincent Gagné (UdeM: Université de Montréal)H-Index: 9
#2Pascal St-Onge (UdeM: Université de Montréal)H-Index: 6
Last. Daniel Sinnett (UdeM: Université de Montréal)H-Index: 49
view all 11 authors...
Aim: To evaluate the association between human leukocyte antigen (HLA) alleles and native Escherichia coli asparaginase hypersensitivity (AH) in children with acute lymphoblastic leukemia (ALL) who received Dana-Farber Cancer Institute treatment protocols. Patients & methods: HLA-DQA1, HLA-DRB1 and HLA-DQB1 alleles were retrieved from available whole exome sequencing data of a subset of childhood ALL patients from Quebec ALL cohort and analyzed for an association with AH. PCR assay was developed...
#1Linfeng Chen (Harvard University)H-Index: 14
#2Jing Ouyang (Harvard University)H-Index: 17
Last. Margaret A. Shipp (Harvard University)H-Index: 75
view all 12 authors...
B-cell receptor signaling pathway components represent promising treatment targets in multiple B-cell malignancies including diffuse large B-cell lymphoma. In in vitro and in vivo model systems, a subset of diffuse large B-cell lymphomas depend upon B-cell receptor survival signals and respond to proximal B-cell receptor/phosphoinositide 3 kinase blockade. However, single-agent B-cell receptor pathway inhibitors have had more limited activity in patients with diffuse large B-cell lymphoma, under...
2 CitationsSource
#1Luca Malcovati (UNIPV: University of Pavia)H-Index: 53
#2Kristen E. Stevenson (Harvard University)H-Index: 39
Last. Pierre FenauxH-Index: 102
view all 36 authors...
The 2016 revision of the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues is characterized by a closer integration of morphology and molecular genetics. Notwithstanding, the myelodysplastic syndrome (MDS) with isolated del(5q) remains so far the only MDS subtype defined by a genetic abnormality. About half of MDS patients carry somatic mutations in spliceosome genes, with SF3B1 being the most commonly mutated one. SF3B1 mutation identifies a conditio...
1 CitationsSource