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Manuela Rossol
Leipzig University
37Publications
14H-index
1,030Citations
Publications 37
Newest
#1Mennatallah Gowayed (Pharos University in Alexandria)H-Index: 2
#2Kathrin Rothe (Leipzig University)H-Index: 6
Last.Rowaida Refaat (Alexandria University)H-Index: 4
view all 0 authors...
Abstract Objective The evolution of the “cholinergic anti-inflammatory pathway” and the fact that the α 7 subunit of the nicotinic acetylcholine receptor (α7nAChR) is present in the spleen, joint and on the surface of lymphocytes, opened up the prospective in this study of targeting the α7nAChR by the anticholinesterase and cholinergic drug, galantamine, to control inflammation in rheumatoid arthritis (RA). Methods Twelve-adjuvant arthritic rats were exposed to the selective α7nAChR blocker meth...
#1Kathleen Friedrich (Leipzig University)H-Index: 1
#2Miriam Sommer (Leipzig University)
Last.Manuela Rossol (Leipzig University)H-Index: 14
view all 7 authors...
Circulating monocytes can be divided into classical (CM), intermediate (IM), and non-classical monocytes (NCM), and the classical monocytes also contain CD56+ monocytes and monocytic myeloid-derived suppressor cells (M-MDSC). Aim of the study was to evaluate the occurrence of the monocyte subpopulations in human obesity. 27 normal, 23 overweight, and 60 obese individuals (including 17 obese individuals with normal glucose tolerance and 27 with type 2 diabetes) were included into this study. Peri...
#1Nora Raulien (Leipzig University)H-Index: 4
#2Kathleen Friedrich (Leipzig University)H-Index: 1
Last.Ulf Wagner (Leipzig University)H-Index: 25
view all 10 authors...
Monocytes enter sites of microbial or sterile inflammation as the first line of defense of the immune system and initiate pro-inflammatory effector mechanisms. We show that activation with bacterial lipopolysaccharide (LPS) induces them to undergo a metabolic shift towards aerobic glycolysis, similar to the Warburg effect observed in cancer cells. At sites of inflammation, however, glucose concentrations are often drastically decreased, which prompted us to study monocyte function under conditio...
#1Kathrin Rothe (Leipzig University)H-Index: 6
#2Dagmar Quandt (Leipzig University)H-Index: 9
Last.Ulf Wagner (Leipzig University)H-Index: 25
view all 11 authors...
Objective Leukocyte immunoglobulin-like receptor 1 (LIR-1) is up-regulated by cytomegalovirus (CMV), which in turn, has been associated with premature aging and more severe joint disease in patients with rheumatoid arthritis (RA). The aim of this study was to investigate the expression and functional significance of LIR-1 in CMV-positive RA patients. Methods We determined the phenotype, cytolytic potential, CMV-specific proliferation, and HLA–G–triggered, LIR-1–mediated inhibition of interferon-...
#1Dagmar QuandtH-Index: 9
#2Kathrin RotheH-Index: 6
Last.Manuela RossolH-Index: 14
view all 4 authors...
GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses
#1Undine Meusch (Leipzig University)H-Index: 7
#2Marco Krasselt (Leipzig University)H-Index: 5
Last.Ulf Wagner (Leipzig University)H-Index: 25
view all 6 authors...
Background Treatment with TNF inhibitors is very efficient in the majority of the patients with rheumatoid arthritis (RA), but it does not achieve a sufficient treatment response in 40–50% of the cases. Goal of the study was to assess functional ex vivo-tests of RA monocytes as prognostic parameters of the subsequent treatment response.
#1Nora Raulien (Leipzig University)H-Index: 4
#2Stefan Rubner (Leipzig University)H-Index: 5
Last.Ulf Wagner (Leipzig University)H-Index: 25
view all 5 authors...
Objective: Stimulation of peripheral blood monocytes and tissue resident macrophages by bacterial endotoxins is a crucial event required for subsequent innate immune responses. It has been shown previously, that binding of LPS to its receptor TLR4 shifts the metabolic state of macrophages and dendritic cells cells towards aerob glycolysis. Methodology: FACS based detection of mitochondrial membrane potential as well as OCR and ECAR measurements on a Seahorse XF analyzer were used to investigate ...
#1Kathrin Rothe (Leipzig University)H-Index: 6
#2Dagmar Quandt (Leipzig University)H-Index: 9
Last.Ulf Wagner (Leipzig University)H-Index: 25
view all 11 authors...
#1Undine Meusch (Leipzig University)H-Index: 7
#2Maria Klingner (Leipzig University)H-Index: 4
Last.Ulf Wagner (Leipzig University)H-Index: 25
view all 7 authors...
Objective Dysregulated apoptosis of monocytes is a pathogenic feature of rheumatoid arthritis (RA). The aim of this study was to investigate the role of TRAIL and TRAIL-induced apoptosis in patients with RA. Methods Cell surface expression and serum concentrations of TRAIL were determined in 63 patients with RA, and TRAIL-induced monocyte apoptosis was quantified. Surface expression of TRAILR-1, TRAILR-2, TRAILR-3, TRAILR-4, CXCR1, and CXCR2 was determined, and intracellular signal transduction ...
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