Jason L. Sperry
University of Pittsburgh
SurgeryIntensive care medicineResuscitationMedicineInjury Severity Score
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Publications 200
BACKGROUND: Modeling approaches offer a novel way to detect and predict coagulopathy in trauma patients. A dynamic model, built and tested on thromboelastogram (TEG) data, was used to generate a virtual library of over 160,000 simulated RapidTEGs. The patient-specific parameters are the initial platelet count, platelet activation rate, thrombus growth rate, and lysis rate (P(0), k1, k2, and k3, respectively). METHODS: Patient data from both STAAMP (n=182 patients) and PAMPer (n=111 patients) cli...
#1Nabil Awan (University of Pittsburgh)H-Index: 2
#2Dominic DiSanto (University of Pittsburgh)H-Index: 1
Last. Amy K. WagnerH-Index: 34
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Abstract Objective To describe the interrelationship of post-injury employment and substance abuse (SA) among individuals with traumatic brain injury (TBI). Design Structural equation model (SEM) and logistic regression analytic approach using a merged database of the National Trauma Data Bank (NTDB) and TBI Model Systems National Database (TBIMS-NDB), with acute care and rehabilitation hospitalization data and 1, 2, and 5-year follow-up data. Setting United States Level I/II trauma centers and ...
BACKGROUND: Individuals with traumatic brain injury (TBI) have extended inpatient hospital stays that include prolonged mechanical ventilation, increasing risk for infections, including pneumonia. Studies show the negative short-term effects of hospital-acquired pneumonia (HAP) on hospital-based outcomes; however, little is known of its long-term effects. METHODS: A prospective cohort study was conducted. National Trauma Databank and Traumatic Brain Injury Model Systems were merged to derive a c...
#1Danielle S. Gruen (University of Pittsburgh)H-Index: 5
#2Joshua B. Brown (University of Pittsburgh)H-Index: 18
Last. Richard S. Miller (VUMC: Vanderbilt University Medical Center)H-Index: 21
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BACKGROUND: Prehospital plasma improves survival in severely injured trauma patients at risk for hemorrhagic shock and transported by air ambulance. We hypothesized that prehospital plasma would be associated with a reduction in immune imbalance and endothelial damage. METHODS: We collected blood samples from 405 trauma patients enrolled in the Prehospital Air MedicalPlasma (PAMPer) trial upon hospital admission (0 hours) and 24 hours post admission across 6 U.S. sites(9 level-one trauma centers...
#1Andrew-Paul Deeb (University of Pittsburgh)H-Index: 9
Last. Joshua B. BrownH-Index: 18
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BACKGROUND: There are well known disparities for patients injured in rural vs urban settings. Many cite access to care; however, the mechanisms are not defined. One potential factor is differences in field triage. Our objective was to evaluate differences in prehospital undertriage (UT) in rural vs urban settings. METHODS: Adult patients in PTOS 2000-2017 were included. Rural/urban setting was defined by county according to the Pennsylvania Trauma Systems Foundation. Rural/urban classification w...
#1Mark H. YazerH-Index: 30
#2Philip C. SpinellaH-Index: 43
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Editor’s PerspectiveWhat We Already Know about This TopicUncrossmatched erythrocyte units that are provided to a massively bleeding patient whose ABO group is unknown must be type O to ensure compatibility. The effect of transfusing type O units on the ability to subsequently determine the patient’s
#2Frank X. Guyette (University of Pittsburgh)H-Index: 5
Last. Raquel M. ForsytheH-Index: 19
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INTRODUCTION: A recent analysis derived from the PAMPer trial dataset demonstrated no significant independent plasma survival benefit in those who required massive transfusion ( >/=10 units of red cells in 24 hours). The definition of massive transfusion has evolved over time to minimize bias and predict those at highest risk of death. We sought to characterize the definition of massive transfusion, their associated mortality risks and the survival benefit associated with prehospital plasma. MET...
BACKGROUND: Randomized clinical trials(RCTs) support the use of pre-hospital plasma in traumatic hemorrhagic shock, especially in long transports. The citrate added to plasma binds with calcium, yet most pre-hospital trauma protocols have no guidelines for calcium replacement. We reviewed the experience of two recent pre-hospital plasma RCTs regarding admission ionized-calcium (i-Ca) blood levels and its impact on survival. We hypothesized that pre-hospital plasma is associated with hypocalcemia...
#1Anthony E. PusateriH-Index: 27
#2Ernest E. Moore (University of Colorado Denver)H-Index: 113
Last. Jason L. Sperry (University of Pittsburgh)H-Index: 39
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Importance Both military and civilian clinical practice guidelines include early plasma transfusion to achieve a plasma to red cell ratio approaching 1:1 to 1:2. However, it was not known how early plasma should be given for optimal benefit. Two recent randomized clinical trials were published, with apparently contradictory results. The Prehospital Air Medical Plasma (PAMPer) clinical trial showed a nearly 30% reduction in mortality with plasma transfusion in the prehospital environment, while t...
2 CitationsSource
#1Sara P. MyersH-Index: 4
#2Mitchell DyerH-Index: 5
Last. Matthew D. NealH-Index: 25
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BACKGROUND: Concern remains over reliable point-of-care testing to guide reversal of rivaroxaban, a commonly used factor Xa inhibitor, in high-acuity settings. Thromboelastography (TEG), a point-of-care viscoelastic assay, may have the ability to detect the anticoagulant effect of rivaroxaban. The authors ascertained the association of apparent rivaroxaban concentration with thromboelastography reaction time, i.e., time elapsed from blood sample placement in analyzer until beginning of clot form...