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Kirsty Minton
Elsevier
ImmunologyT cellB cellBiologyCell biology
354Publications
6H-index
308Citations
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Publications 352
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Ramanan et al. describe a maternally transmitted variance in colonic populations of regulatory T cells that depends on IgA levels in maternal milk.
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A recent study in Science describes a role for dendritic cell-derived hepcidin in iron sequestration in the gut to regulate the microbiota and promote tissue repair.
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Two studies published in Nature report that gasdermin-mediated pyroptosis of tumour cells induces cytotoxic lymphocyte-mediated antitumour immune responses.
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Febrile temperature increases the differentiation of T helper 17 (TH17) cells with a more pro-inflammatory, pathogenic phenotype, which could have implications for the pathogenesis of autoimmunity.
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McGinley et al. describe a new role for IL-17A in the induction phase of experimental autoimmune encephalomyelitis by indirectly recruiting IL-1β-producing myeloid cells.
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Overexpression of JUN by CAR T cells renders them resistant to exhaustion and improves tumour control in mouse models, including of solid tumours and of tumours with low levels of antigen expression.
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The host aryl hydrocarbon receptor can detect various quorum-sensing molecules produced by Pseudomonas aeruginosa, which may allow host immune cells to tune their response according to the bacterial density.
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Endogenous oxidized phospholipids can induce a hypermetabolic state in macrophages, involving both oxidative phosphorylation and aerobic glycolysis, that boosts the inflammatory response to lipopolysaccharide.
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Chen Dong and colleagues describe a positive-feedback loop between TOX2 and BCL-6 that helps to drive the development of T follicular helper cells in germinal centres.
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