Match!
Anne-Marie Malfait
Rush University Medical Center
Physical therapyAggrecanOsteoarthritisCartilageMedicine
138Publications
33H-index
3,801Citations
What is this?
Publications 143
Newest
#1Rachel E. Miller (Rush University Medical Center)H-Index: 18
#2P.B. Tran (Rush University Medical Center)H-Index: 7
Last. Anne-Marie Malfait (Rush University Medical Center)H-Index: 33
view all 8 authors...
Summary Objective Following destabilization of the medial meniscus (DMM), mice develop experimental osteoarthritis (OA) and associated pain behaviors that are dependent on the stage of disease. We aimed to describe changes in gene expression in knee-innervating dorsal root ganglia (DRG) after surgery, in order to identify molecular pathways associated with three pre-defined pain phenotypes: “post-surgical pain”, “early-stage OA pain”, and “persistent OA pain”. Design We performed DMM or sham sur...
Source
#1Anne-Marie Malfait (Rush University Medical Center)H-Index: 33
#2Rachel E. Miller (Rush University Medical Center)H-Index: 18
Source
#1Richard J. Miller (NU: Northwestern University)H-Index: 78
#2Anne-Marie Malfait (Rush University Medical Center)H-Index: 33
Last. Rachel E. Miller (Rush University Medical Center)H-Index: 18
view all 3 authors...
Summary In this narrative review, we discuss the emerging role of innate immunity in OA joint pain. First, we give a brief description of the pain pathway in the context of OA. Then we consider how neuro-immune signaling pathways may promote OA pain. First, activation of neuronal Pattern Recognition Receptors by mediators released in a damaged joint can result in direct excitation of nociceptors, as well as in production of chemokines and cytokines. Secondly, indirect neuro-immune signaling may ...
2 CitationsSource
#1Rachel E. Miller (Rush University Medical Center)H-Index: 18
#2Carla R. Scanzello (UPenn: University of Pennsylvania)H-Index: 14
Last. Anne-Marie Malfait (Rush University Medical Center)H-Index: 33
view all 3 authors...
Osteoarthritis (OA) is a chronic progressive, painful disease of synovial joints, characterized by cartilage degradation, subchondral bone remodeling, osteophyte formation, and synovitis. It is now widely appreciated that the innate immune system, and in particular Toll-like receptors (TLRs), contributes to pathological changes in OA joint tissues. Furthermore, it is now also increasingly recognized that TLR signaling plays a key role in initiating and maintaining pain. Here, we reviewed the lit...
3 CitationsSource
#1J. Chua (Rush University Medical Center)H-Index: 1
#2Shakeel Jamal (Rush University Medical Center)H-Index: 1
Last. Theodore Pincus (Rush University Medical Center)H-Index: 88
view all 7 authors...
1 CitationsSource
#1Alia M. Obeidat (Rush University Medical Center)H-Index: 1
#2Rachel E. Miller (Rush University Medical Center)H-Index: 18
Last. Anne-Marie Malfait (Rush University Medical Center)H-Index: 33
view all 4 authors...
Summary Objectives To document the nociceptive innervation of the normal and osteoarthritic murine knee. Methods Knees were collected from naive male C57BL/6 NaV1.8-tdTomato reporter mice aged 10, 26, and 52 weeks (n=5/group). Destabilization of the medial meniscus (DMM) or sham surgeries (n=5/group) were performed in the right knee of 10-week old male NaV1.8-tdTomato mice, and knees were harvested 16 weeks later. Twenty 20-μm frozen sections from a 400-μm mid-joint region were collected for con...
Source
#1Martin SchmelzH-Index: 72
#2Patrick W. MantyhH-Index: 84
Last. Lars ViktrupH-Index: 29
view all 7 authors...
AbstractChronic pain continues to be a significant global burden despite the availability of a variety of nonpharmacologic and pharmacologic treatment options. Thus, there is a need for new analgesics with novel mechanisms of action. In this regard, antibodies directed against nerve growth factor (N
Source
Source
#1P.B. TranH-Index: 7
#2S. IshiharaH-Index: 6
Last. Anne-Marie MalfaitH-Index: 33
view all 5 authors...
Source
#1Rachel E. MillerH-Index: 18
#2S. IshiharaH-Index: 6
Last. Anne-Marie MalfaitH-Index: 33
view all 3 authors...
Source
12345678910