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Paul I. Terasaki
University of California, Los Angeles
AntibodyHuman leukocyte antigenImmunologyDiabetes mellitusMedicine
882Publications
91H-index
39.6kCitations
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Publications 868
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#2Vadim JucaudH-Index: 6
Last. Paul I. TerasakiH-Index: 91
view all 7 authors...
Luminex multiplex immunoassays enable simultaneous monitoring of Abs against multiple Ags in autoimmune, inflammatory, and infectious diseases. The assays are used extensively to monitor anti-HLA Abs in transplant patients for donor organ selection, desensitization, and assessing the risk for graft rejection. To monitor IgG Abs, fluoresceinated IgG constant H chain–binding polyclonal F(ab′) 2 ( IgHPolyFab ) is used as the fluoresceinated secondary Ab (2nd-Ab), whereas IgG subclasses are monitore...
3 CitationsSource
#1Elaine Y. ChengH-Index: 4
#2Matthew J. EverlyH-Index: 18
Last. Douglas G. FarmerH-Index: 61
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BackgroundRejection remains the leading cause of allograft loss, and a major barrier to improving long-term outcomes after intestinal transplantation. Our aim is to define the prevalence and investigate the role of donor-specific antibody (DSA) on intestinal graft outcomes.MethodsThe study includes
17 CitationsSource
#1Vadim JucaudH-Index: 6
Last. Paul I. TerasakiH-Index: 91
view all 3 authors...
BackgroundSingle antigen beads (SAB) are used for monitoring HLA antibodies in pretransplant and posttransplant patients despite the discrepancy between virtual and actual crossmatch results and transplant outcomes. This discrepancy can be attributed to the presence of conformational variants of HLA
8 CitationsSource
#1Nils Lachmann (Charité)H-Index: 18
#2Constanze Schönemann (Charité)H-Index: 23
Last. Johannes Waiser (Charité)H-Index: 14
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A considerable proportion of patients awaiting kidney transplantation is immunized by previous transplantation(s). We investigated how allograft nephrectomy (Nx) and withdrawal of maintenance immunosuppression (WD-MIS) in patients with a failed renal allograft contribute to allosensitization.HLA antibodies (HLAabs) were analyzed before and after Nx and/or WD-MIS using a single antigen bead assay. Patients were grouped as follows: (A) Nx and concomitant WD-MIS (n = 28), (B) Nx (n = 14) and (C) WD...
12 CitationsSource
#1Vadim JucaudH-Index: 6
Last. Robert Biesen (Humboldt University of Berlin)H-Index: 13
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Summary T lymphocyte hyperactivity and progressive inflammation in systemic lupus erythematosus (SLE) patients results in over-expression of human leucocyte antigen (HLA)-Ib on the surface of lymphocytes. These are shed into the circulation upon inflammation, and may augment production of antibodies promoting pathogenicity of the disease. The objective was to evaluate the association of HLA-Ib (HLA-E, HLA-F and HLA-G) antibodies to the disease activity of SLE. The immunoglobulin (Ig)G/IgM reacti...
8 CitationsSource
#2Vadim JucaudH-Index: 6
Last. Paul I. TerasakiH-Index: 91
view all 4 authors...
Abstract The presence of IgG against pathogens in the cord blood (CB) of vaccinated mothers is attributed to transplacental transfer. However, previous studies using lymphocytotoxicity assay showed anti-HLA IgG in mother’s blood (MB) but not in CB, perhaps due to non-transfer of anti-HLA IgG or assay limitations in detecting anti-HLA IgG. Anti-HLA IgG of native and purified sera of 16 MB and CB pairs were measured using an array of microbeads coated with HLA-I/-II molecules on a Luminex platform...
1 CitationsSource
#1Junchao CaiH-Index: 20
#2Paul I. TerasakiH-Index: 91
Last. Xin Qing (UCLA Medical Center)H-Index: 7
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Abstract Background We have found antibodies against denatured HLA class I antigens in the serum of allograft recipients which were not significantly associated with graft failure. It is unknown whether transplant recipients also have denatured HLA class II and MICA antibodies. The effects of denatured HLA class I, class II, and MICA antibodies on long-term graft outcome were further investigated based on their ability to fix complement c1q. Materials and methods In this 4-year retrospective coh...
11 CitationsSource
#1Jacqueline G. O'Leary (Baylor University Medical Center)H-Index: 39
#2Junchao CaiH-Index: 20
Last. A. J. Demetris (University of Pittsburgh)H-Index: 25
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Abstract Donor-specific alloantibodies (DSA) can cause acute antibody-mediated rejection (AMR) in all solid organ allografts. However, long-term outcome in patients with posttransplant DSA needs further study. We retrospectively evaluated prospectively collected paired serum, tissue, and data on 45 matched DSA- positive [DSA+; mean florescence intensity (MFI) ≥10 000] and -negative (DSA-) recipients of a primary liver-only allograft from January 2000 to April 2009. Blinded histopathologic evalua...
43 CitationsSource
#1G. DieplingerH-Index: 3
#2Matthew J. EverlyH-Index: 18
Last. Lorita M. Rebellato (ECU: East Carolina University)H-Index: 15
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BK polyomavirus (BKPyV) viremia/nephropathy and reduction in immunosuppression following viremia may increase the risk of alloimmune activation and allograft rejection. This study investigates the impact of BKPyV viremia on de novo donor anti-human leukocyte antigen (HLA)-specific antibodies (dnDSA).All primary renal transplants at East Carolina University from March 1999 to December 2010, with at least 1 post-transplant BKPyV viral load testing, were analyzed. Patients were negative for anti-HL...
12 CitationsSource
#1Vadim JucaudH-Index: 6
Last. Paul I. TerasakiH-Index: 91
view all 3 authors...
4 CitationsSource
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