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Catriona Syme
University of Toronto
39Publications
14H-index
689Citations
Publications 39
Newest
#1Jean Shin (U of T: University of Toronto)H-Index: 6
#2Catriona Syme (U of T: University of Toronto)H-Index: 14
Last.Zdenka Pausova (U of T: University of Toronto)H-Index: 36
view all 8 authors...
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#1Catriona Syme (U of T: University of Toronto)H-Index: 14
#2Jean Shin (U of T: University of Toronto)H-Index: 6
Last.Zdenka Pausova (U of T: University of Toronto)H-Index: 36
view all 6 authors...
High blood pressure (BP) is the strongest modifiable risk factor for cardiovascular disease. Overweight/obesity is a major risk factor of high BP. Multiple sex differences exist in mechanistic path...
Source
#1Catriona Syme (U of T: University of Toronto)H-Index: 14
#2Stephanie Pelletier (U of T: University of Toronto)
Last.Zdenka Pausova (U of T: University of Toronto)H-Index: 36
view all 17 authors...
Life-long maintenance of brain health is important for the prevention of cognitive impairment in older age. Low-grade peripheral inflammation associated with excess visceral fat (VF) may influence brain structure and function. Here we examined (i) if this type of inflammation is associated with altered white-matter (WM) microstructure and lower cognitive functioning in adolescents, and (ii) if recently identified circulating glycerophosphocholines (GPCs) can index this type of inflammation and a...
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#1Catriona SymeH-Index: 14
#2Jean ShinH-Index: 6
Last.Zdenka PausovaH-Index: 36
view all 7 authors...
Source
#1Catriona SymeH-Index: 14
#2Jean ShinH-Index: 6
Last.Zdenka PausovaH-Index: 36
view all 7 authors...
Source
#1Melissa Richard (University of Texas Health Science Center at Houston)H-Index: 9
#2Tianxiao HuanH-Index: 24
Last.Myriam Fornage (University of Texas Health Science Center at Houston)H-Index: 76
view all 113 authors...
Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small fraction of the phenotypic variance. Epigenetic changes may alter the expression of genes involved in BP regulation and explain part of the missing heritability. We therefore conducted a two-stage meta-analysis of the cross-sectional associations of systolic and diastolic BP with blood-derived genome-wide DNA methylation measured on the Inf...
24 CitationsSource
#1Catriona SymeH-Index: 14
#2Jean ShinH-Index: 6
Last.Zdenka PausovaH-Index: 36
view all 10 authors...
Hypertension is a leading cause of death. Sex differences in blood pressure (BP) and hypertension prevalence emerge during adolescence and remain throughout reproductive age. Sex differences in BP-underlying hemodynamics, i.e., in the relative contributions of stroke volume (SV), total peripheral resistance (TPR) and heart rate (HR) to BP, have not been investigated in these age categories in a population-based setting. We studied a cohort of 1,347 individuals, including 911 adolescents (12-18 y...
#1Greg D. WellsH-Index: 18
#2Laura BanksH-Index: 9
Last.HamiltonJill (U of T: University of Toronto)H-Index: 30
view all 9 authors...
Background Obesity is associated with cardiometabolic disturbances, which may have significant implications for musculoskeletal health and exercise tolerance. Objective We sought to determine the association between muscle structure, function, and metabolism in adolescents across the weight spectrum. Methods This cross-sectional case–control study included overweight and obese participants (n = 24) 8–18 years of age with a body mass index (BMI) ≥ 85th percentile for age and gender, and non-obese...
3 CitationsSource
This Mini-Review describes sex differences in 66 quantitative characteristics of the brain and body measured in a community-based sample of 1,024 adolescents 12–18 years of age, members of the Saguenay Youth Study. Using an extensive phenotyping protocol, we have obtained measures in a number of domains, including brain structure, cognition, mental health, substance use, body composition, metabolism, cardiovascular reactivity, and life style. For each measure, we provide estimates of effect size...
15 CitationsSource
#1Catriona SymeH-Index: 14
#2Simon CzajkowskiH-Index: 1
Last.Zdenka PausovaH-Index: 36
view all 16 authors...
Background: Glycerophosphocholine (GPC) metabolites modulate atherosclerosis and thus risk for cardiovascular disease (CVD). Preclinical CVD may start during adolescence. Here, we used targeted serum lipidomics to identify a new panel of GPCs, and tested whether any of these GPCs are associated, in adolescence, with classical risk factors of CVD, namely excess visceral fat (VF), elevated blood pressure, insulin resistance, and atherogenic dyslipidemia. Methods: We studied a population-based samp...
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