Match!
Konstantinos Evangelou
National and Kapodistrian University of Athens
41Publications
18H-index
1,147Citations
Publications 41
Newest
#1Panagiotis Vasileiou (UoA: National and Kapodistrian University of Athens)H-Index: 10
#2Konstantinos Evangelou (UoA: National and Kapodistrian University of Athens)H-Index: 18
Last.Sophia Havaki (UoA: National and Kapodistrian University of Athens)H-Index: 8
view all 10 authors...
Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a co...
1 CitationsSource
#1Alexandra Barbouti (UoI: University of Ioannina)H-Index: 11
#2Konstantinos Evangelou (UoI: University of Ioannina)H-Index: 18
Last.Vassilis G. Gorgoulis (University of Manchester)H-Index: 10
view all 10 authors...
Abstract Cellular senescence, an age-related process in response to damage and stress, also occurs during normal development and adult life. The thymus is a central lymphoepithelial organ of the immune system that exhibits age-related changes termed thymic involution. Since the mechanisms regulating thymic involution are still not well elucidated, we questioned whether cellular senescence is implicated in this process. We demonstrate, for the first time in situ , that cellular senescence occurs ...
3 CitationsSource
#1Vassilios Myrianthopoulos (UoA: National and Kapodistrian University of Athens)H-Index: 13
#2Konstantinos Evangelou (UoI: University of Ioannina)H-Index: 18
Last.Vassilis G. GorgoulisH-Index: 47
view all 10 authors...
Abstract Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal activation during embryonic development or normal adult life is linked with beneficial properties. In contrast, persistent (chronic) senescence seems to exert detrimental effects fostering aging and age-related disorders, such as cancer. Due to the lack of a reliable marker able to detect senescence in vivo, its precise impact in age-related diseases is to a large extent still undetermined. A novel rea...
11 CitationsSource
#1Sophia V. Rizou (UoA: National and Kapodistrian University of Athens)H-Index: 4
#2Konstantinos Evangelou (UoI: University of Ioannina)H-Index: 18
Last.Vassilis G. GorgoulisH-Index: 47
view all 15 authors...
Source
Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular senescence is a homeostatic biological process that has a key role in driving ageing. There is evidence that senescent cells accumulate in the nervous system with ageing and neurodegenerative disease and may predispose a person to the appearance of a neurodegenerative condition or may aggravate its course. Research into senescence has long been hindered by its variable and cell-type specific features and the l...
13 CitationsSource
#1Sophia Havaki (UoA: National and Kapodistrian University of Athens)H-Index: 8
#2Vassiliki Vlachou (UoA: National and Kapodistrian University of Athens)H-Index: 2
Last.Vassilis G. GorgoulisH-Index: 47
view all 12 authors...
Autophagy is a catabolic process that preserves cellular homeostasis. Its exact role during carcinogenesis is not completely defined. Specifically in head and neck cancer, such information from clinical settings that comprise the whole spectrum of human carcinogenesis is very limited. Towards this direction, we examined the in situ status of the autophagy-related factors, Beclin-1, microtubule-associated protein 1 light chain 3, member B (LC3B) and sequestosome 1/p62 (p62) in clinical material c...
2 CitationsSource
#1Konstantinos Evangelou (UoA: National and Kapodistrian University of Athens)H-Index: 18
#2Nikolaos Lougiakis (UoA: National and Kapodistrian University of Athens)H-Index: 6
Last.Vassilis G. Gorgoulis (University of Manchester)H-Index: 10
view all 13 authors...
Summary Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. Here, we designed and synthesized a lipophilic, biotin-linked Sudan Black B (SBB) analogue suitable for sensitive and specific, antibody-enhanced detection of lipofuscin-containing senescent cells in any biological material. This new hybrid histo-/immunochemical method is easy to perform, reliable, and universally applicable to a...
47 CitationsSource
#1Konstantinos Evangelou (UoA: National and Kapodistrian University of Athens)H-Index: 18
#2Vassilis G. Gorgoulis (University of Manchester)H-Index: 10
11 CitationsSource
#1Sotirios K. Sotiriou (University of Geneva)H-Index: 7
#2Irene Kamileri (University of Geneva)H-Index: 4
Last.Thanos D. Halazonetis (University of Geneva)H-Index: 51
view all 16 authors...
Summary Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks. To better understand BIR, we performed a targeted siRNA screen for genes whose depletion inhibited G1 to S phase progression when oncogenic cyclin E was overexpressed. RAD52 , a gene dispensable for normal development in mice, was among the top hits. In cells in which fork coll...
82 CitationsSource
#1Laura Herrtwich (University of Freiburg)H-Index: 1
#2Indrajit NandaH-Index: 37
Last.Antigoni Triantafyllopoulou (University of Freiburg)H-Index: 4
view all 38 authors...
Granulomas are immune cell aggregates formed in response to persistent inflammatory stimuli. Granuloma macrophage subsets are diverse and carry varying copy numbers of their genomic information. The molecular programs that control the differentiation of such macrophage populations in response to a chronic stimulus, though critical for disease outcome, have not been defined. Here, we delineate a macrophage differentiation pathway by which a persistent Toll-like receptor (TLR) 2 signal instructs p...
30 CitationsSource
12345