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Christian Wolfrum
ETH Zurich
145Publications
29H-index
4,725Citations
Publications 145
Newest
Published on Apr 18, 2019in Nature Communications 11.88
Wanze Chen3
Estimated H-index: 3
(EPFL: École Polytechnique Fédérale de Lausanne),
Petra C. Schwalie14
Estimated H-index: 14
(EPFL: École Polytechnique Fédérale de Lausanne)
+ 12 AuthorsJulie Russeil2
Estimated H-index: 2
(EPFL: École Polytechnique Fédérale de Lausanne)
Kruppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revealed that KFZPs contribute to a wide variety of other biological processes. Using murine and human in vitro and in vivo models, we demonstrate here that one poorly studied KZFP, ZFP30, promotes adipogenesis by directly targeting and activating a...
Published on Dec 1, 2019in Scientific Reports 4.01
Niels Banhos Danneskiold-Samsøe3
Estimated H-index: 3
(UCPH: University of Copenhagen),
Si Brask Sonne19
Estimated H-index: 19
(UCPH: University of Copenhagen)
+ 17 AuthorsLoris Sartini3
Estimated H-index: 3
(Marche Polytechnic University)
Cyclooxygenases are known as important regulators of metabolism and immune processes via conversion of C20 fatty acids into various regulatory lipid mediators, and cyclooxygenase activity has been implicated in browning of white adipose tissues. We generated transgenic (TG) C57BL/6 mice expressing the Ptgs2 gene encoding cyclooxygenase-2 (COX-2) in mature adipocytes. TG mice fed a high-fat diet displayed marginally lower weight gain with less hepatic steatosis and a slight improvement in insulin...
Published on Feb 1, 2018in Nutritional Neuroscience 3.95
Christian Wolfrum29
Estimated H-index: 29
(ETH Zurich),
Daria Peleg-Raibstein12
Estimated H-index: 12
(ETH Zurich)
Objectives: Epidemiological studies have linked maternal obesity with metabolic as well as psychiatric disorders in the progeny. However, very little is known how maternal overnutrition may affect the cognitive abilities of the offspring.Methods: Here, we tested the hypothesis whether maternal high-fat diet (HFD) exposure in mice may induce long-term cognitive impairments and neurochemical dysfunctions in the offspring during different age trajectories.Results: We found that maternal HFD led to ...
Jasper de Jong (Yale University), Wenfei Sun4
Estimated H-index: 4
(Technische Hochschule)
+ -3 AuthorsMuhammad Hamza Bokhari (Stockholm University)
Human and rodent brown adipose tissues (BAT) appear morphologically and molecularly different. Here we compare human BAT with both classical brown and brite/beige adipose tissues of ‘physiologically humanized’ mice: middle-aged mice living under conditions approaching human thermal and nutritional conditions, that is, prolonged exposure to thermoneutral temperature (approximately 30 °C) and to an energy-rich (high-fat, high-sugar) diet. We find that the morphological, cellular and molecular char...
Published in Phytomedicine 4.18
Elisabeth Buhlmann (UHH: University of Hamburg), Carla Horvath (EPFL: École Polytechnique Fédérale de Lausanne)+ -3 AuthorsSven Schröder10
Estimated H-index: 10
(UHH: University of Hamburg)
Abstract Background Obesity is one of the major health problems worldwide. The induction of brown adipocyte formation and activity represents a promising therapeutic option by increasing energy expenditure. Asian herbs have the potential to treat obesity, however, pharmacological effects should be well documented at the molecular level first. Hypothesis A novel hypothesis-driven screening approach identified the root of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep (PLR) to have poten...
Published on Aug 1, 2019in Metabolomics 3.17
Shuaizhen Zhou1
Estimated H-index: 1
(UNIL: University of Lausanne),
Pierre-Marie Allard8
Estimated H-index: 8
(UNIL: University of Lausanne)
+ 4 AuthorsJean-Luc Wolfender47
Estimated H-index: 47
(UNIL: University of Lausanne)
Introduction Bitter melon (Momordica charantia, Cucurbitaceae) is a popular edible medicinal plant, which has been used as a botanical dietary supplement for the treatment of diabetes and obesity in Chinese folk medicine. Previously, our team has proved that cucurbitanes triterpenoid were involved in bitter melon’s anti-diabetic effects as well as on increasing energy expenditure. The triterpenoids composition can however be influenced by changes of varieties or habitats.
Published on Jul 15, 2019in Diabetologia 7.11
Leon G. Straub5
Estimated H-index: 5
(EPFL: École Polytechnique Fédérale de Lausanne),
Vissarion Efthymiou (EPFL: École Polytechnique Fédérale de Lausanne)+ 10 AuthorsMyrtha Arnold7
Estimated H-index: 7
(EPFL: École Polytechnique Fédérale de Lausanne)
Aims/hypothesis In the context of diabetes, the health benefit of antioxidant treatment has been widely debated. In this study, we investigated the effect of antioxidant treatment during the development of insulin resistance and hyperphagia in obesity and partial lipodystrophy.
Published on Jul 14, 2019
Miroslav Balaz9
Estimated H-index: 9
,
Christian Wolfrum29
Estimated H-index: 29
Published on Jun 6, 2019in Embo Molecular Medicine 10.62
Tenagne D. Challa2
Estimated H-index: 2
(Boston Children's Hospital),
Stephan Wueest15
Estimated H-index: 15
(Boston Children's Hospital)
+ 6 AuthorsDaniel Konrad27
Estimated H-index: 27
(UZH: University of Zurich)
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