Christian Wolfrum
ETH Zurich
Publications 157
#1Wenfei Sun (ETH Zurich)H-Index: 6
#2Hua Dong (ETH Zurich)H-Index: 5
Last.Christian Wolfrum (ETH Zurich)H-Index: 32
view all 15 authors...
Adipose tissue usually is classified as either white, brown or beige/brite, based on whether it functions as an energy storage or thermogenic organ. It serves as an important regulator of systemic metabolism, exemplified by the fact that dysfunctional adipose tissue in obesity leads to a host of secondary metabolic complications such as diabetes, cardiovascular diseases and cancer. In addition, adipose tissue is an important endocrine organ, which regulates the function of other metabolic tissue...
#1Zuzana Kovanicova (SAV: Slovak Academy of Sciences)
#2Timea Kurdiova (SAV: Slovak Academy of Sciences)H-Index: 11
Last.Jozef Ukropec (SAV: Slovak Academy of Sciences)H-Index: 22
view all 13 authors...
Context: Cold-induced activation of thermogenesis modulates energy metabolism, but the role of humoral mediators is not completely understood. Objective: To investigate the role of parathyroid and thyroid hormones in acute and adaptive response to cold in humans. Design: Cross-sectional study examining acute response to ice-water swimming and to experimental non-shivering thermogenesis (NST) induction in individuals acclimatized and non-acclimatized to cold. Seasonal variation in energy metaboli...
#2Mustafa YalcinkayaH-Index: 2
Last.A. von EckardsteinH-Index: 73
view all 25 authors...
#1Wanze Chen (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 3
#2Petra C. Schwalie (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 15
Last.Bart Deplancke (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 40
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Kruppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revealed that KFZPs contribute to a wide variety of other biological processes. Using murine and human in vitro and in vivo models, we demonstrate here that one poorly studied KZFP, ZFP30, promotes adipogenesis by directly targeting and activating a...
#1Birgit Waltenberger (University of Innsbruck)H-Index: 12
Last.Hermann Stuppner (University of Innsbruck)H-Index: 41
view all 17 authors...
#1Niels Banhos Danneskiold-Samsøe (UCPH: University of Copenhagen)H-Index: 4
#2Si Brask Sonne (UCPH: University of Copenhagen)H-Index: 20
Last.Karsten Kristiansen (UCPH: University of Copenhagen)H-Index: 74
view all 20 authors...
Cyclooxygenases are known as important regulators of metabolism and immune processes via conversion of C20 fatty acids into various regulatory lipid mediators, and cyclooxygenase activity has been implicated in browning of white adipose tissues. We generated transgenic (TG) C57BL/6 mice expressing the Ptgs2 gene encoding cyclooxygenase-2 (COX-2) in mature adipocytes. TG mice fed a high-fat diet displayed marginally lower weight gain with less hepatic steatosis and a slight improvement in insulin...
#1Elisabeth Buhlmann (UHH: University of Hamburg)
#2Carla Horvath (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 1
Last.Sven Schröder (UHH: University of Hamburg)H-Index: 11
view all 9 authors...
Abstract Background: Obesity is one of the major health problems worldwide. The induction of brown adipocyte formation and activity represents a promising therapeutic option by increasing energy expenditure. Asian herbs have the potential to treat obesity, however, pharmacological effects should be well documented at the molecular level first. Hypothesis: A novel hypothesis-driven screening approach identified the root of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep (PLR) to have pot...
#1Leon G. Straub (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 6
#2Vissarion Efthymiou (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 3
Last.Christian Wolfrum (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 32
view all 13 authors...
Aims/hypothesis In the context of diabetes, the health benefit of antioxidant treatment has been widely debated. In this study, we investigated the effect of antioxidant treatment during the development of insulin resistance and hyperphagia in obesity and partial lipodystrophy.
#1Camilla Scheele (UCPH: University of Copenhagen)H-Index: 23
#2Christian Wolfrum (ETH Zurich)H-Index: 32
2 CitationsSource
Objectives: Epidemiological studies have linked maternal obesity with metabolic as well as psychiatric disorders in the progeny. However, very little is known how maternal overnutrition may affect the cognitive abilities of the offspring.Methods: Here, we tested the hypothesis whether maternal high-fat diet (HFD) exposure in mice may induce long-term cognitive impairments and neurochemical dysfunctions in the offspring during different age trajectories.Results: We found that maternal HFD led to ...
5 CitationsSource