Thomas J. Fahey
NewYork–Presbyterian Hospital
Publications 218
#1Soyoung Choi (Cornell University)H-Index: 1
#2Dunrui Wang (NIH: National Institutes of Health)
Last.Yi-Chieh Nancy Du (Cornell University)H-Index: 9
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The receptor for hyaluronic acid-mediated motility (RHAMM) is upregulated in various cancers. We previously screened genes upregulated in human hepatocellular carcinomas for their metastatic function in a mouse model of pancreatic neuroendocrine tumor (PNET) and identified that human RHAMMB promoted liver metastasis. It was unknown whether RHAMMB is upregulated in pancreatic cancer or contributes to its progression. In this study, we found that RHAMM protein was frequently upregulated in human P...
While the majority of thyroid cancer patients are easily treatable, those with anaplastic or poorly differentiated recurrent thyroid carcinomas have a very poor prognosis with a median survival of less than a year. Previously, we have shown a significant correlation between ICAM-1 overexpression and malignancy in thyroid cancer, and have pioneered the use of ICAM-1 targeted CAR T cells as a novel treatment modality. For clinical translation of this novel modality, we designed CAR T cells possess...
#1Dessislava Stefanova (NewYork–Presbyterian Hospital)
#2Arpita Bose (NewYork–Presbyterian Hospital)
Last.Toni Beninato (NewYork–Presbyterian Hospital)H-Index: 10
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Background The incidence of papillary thyroid microcarcinoma (PTMC) has increased over the past decade. The American Thyroid Association (ATA) suggests that these patients may undergo either thyroid lobectomy or active surveillance. It remains unclear whether there exists a subgroup of PTMC patients who may benefit from more aggressive treatment due to increased risk of recurrence.
#1Timothy M. Ullmann (NewYork–Presbyterian Hospital)H-Index: 1
#2Katherine D. Gray (NewYork–Presbyterian Hospital)H-Index: 2
Last.Toni Beninato (NewYork–Presbyterian Hospital)H-Index: 10
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#1Timothy M. Ullmann (NewYork–Presbyterian Hospital)H-Index: 1
#2Heng Liang (NewYork–Presbyterian Hospital)
Last.Thomas J. Fahey (NewYork–Presbyterian Hospital)H-Index: 40
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Abstract Background The majority of papillary thyroid cancers are driven by acquired mutations typically in the BRAF or RAS genes that aberrantly activate the mitogen-activated protein kinase pathway. This process leads to malignant transformation, dedifferentiation, and a decrease in the expression of the sodium-iodide symporter (NIS; SLC5A5), which results in resistance to radioactive iodine therapy. We sought to determine whether inhibition of aberrant mitogen-activated protein kinase-signali...
#1Wessel M. C. M. Vorselaars (UU: Utrecht University)H-Index: 5
#2Dirk-Jan van Beek (UU: Utrecht University)H-Index: 2
Last.Menno R. Vriens (UU: Utrecht University)H-Index: 25
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Introduction Complete resolution of hypertension after adrenalectomy for primary aldosteronism is far from a certainty. This stresses the importance of adequate preoperative patient counseling. The aldosteronoma resolution score (ARS) is a simple and easy to use prediction model only including four variables: ≤ 2 antihypertensive medications, body mass index ≤ 25 kg/m2, duration of hypertension ≤ 6 years and female sex. However, because the model was developed and validated within the USA over a...
#1Timothy M. Ullmann (Cornell University)H-Index: 1
#2Katherine D. Gray (Cornell University)H-Index: 2
Last.Toni Beninato (Cornell University)H-Index: 10
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Background Health insurance has been shown to be a key determinant in cancer care, but it is unknown to what extent insurance status affects treatments provided to papillary thyroid cancer (PTC) pa...