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Amani E. Khalifa
Ain Shams University
56Publications
17H-index
1,115Citations
Publications 56
Newest
#1Marwa M. Nagib (Misr International University)H-Index: 1
#2Mariane G. Tadros (Ain Shams University)H-Index: 11
Last.Somaia I. Masoud (Ain Shams University)H-Index: 3
view all 6 authors...
Phenytoin is one of the most well-known antiepileptic drugs that cause cognitive impairment which is closely related to cAMP response element-binding protein (CREB) brain-derived neurotrophic factor (BDNF) signaling pathway. Moreover, vascular endothelial growth factor (VEGF), an endothelial growth factor, has a documented role in neurogenesis and neuronal survival and cognitive impairment. Therefore, this study aimed to investigate the influence of powerful antioxidants: α-Toc and CoQ10 alone o...
1 CitationsSource
#1Marwa M. Nagib (Misr International University)H-Index: 1
#2Mariane G. Tadros (Ain Shams University)H-Index: 11
Last.Somaia I. Masoud (Ain Shams University)H-Index: 3
view all 7 authors...
Abstract Current anticonvulsant therapies are principally aimed at suppressing neuronal hyperexcitability to prevent or control the incidence of seizures. However, the role of oxidative stress processes in seizures led to the proposition that antioxidant compounds may be considered as promising candidates for limiting the progression of epilepsy. Accordingly, the aim of this study is to determine if coenzyme Q10 (CoQ10) and alpha-tocopherol (α-Toc) have a neuroprotective effect in rats against t...
Source
#1Amani E. Khalifa (Ain Shams University)H-Index: 17
#1Rania M. Salama (Misr International University)H-Index: 3
#2Mariane G. Tadros (Ain Shams University)H-Index: 11
Last.Amani E. Khalifa (Ain Shams University)H-Index: 17
view all 6 authors...
Source
#1Rasha M. AllamH-Index: 1
#2Ahmed M. Al-Abd (KAU: King Abdulaziz University)H-Index: 16
Last.Ashraf B. Abdel-Naim (KAU: King Abdulaziz University)H-Index: 20
view all 8 authors...
Abstract Sphingolipids are critical regulators of tumor microenvironments and play an important role in estrogen-dependent cancers. Estrogen and estrogen metabolites were found to be involved in prostate cancer. Fingolimod (FTY720) is a sphingokinase-1 (SphK1) inhibitor with anticancer properties against various tumor cell types. Herein, we investigated the interference of FTY720 with the cross talk between sphingolipid metabolism and estrogen metabolism within prostate cancer cells. FTY720 show...
1 CitationsSource
#1Amr A. Elsayed (Ain Shams University)H-Index: 1
#2Esther T. Menze (Ain Shams University)H-Index: 4
Last.Amani E. Khalifa (Ain Shams University)H-Index: 17
view all 6 authors...
Estrogenic compounds have been documented in literature to exert neuroprotective effects. This study investigated the potential neuroprotective effect of genistein; a phytoestrogen at doses of 5, 10, 20, and 40 mg/kg p.o. in ovariectomized rats challenged with pentylenetetrazole (PTZ) 90 mg/kg i.p. Systemic acute administration of PTZ induced seizures, increased oxidative stress, and caused apoptosis and histological abnormalities. Pretreatment with genistein delayed seizure onset, reduced the s...
2 CitationsSource
#1Sherif M. Shoieb (Ain Shams University)H-Index: 2
#2Ahmed Esmat (Ain Shams University)H-Index: 13
Last.Ashraf B. Abdel-Naim (Ain Shams University)H-Index: 20
view all 4 authors...
Abstract Benign prostate hyperplasia (BPH) is a common age-related health problem affecting almost 3 out of 4 men in their sixties. Chrysin is a dietary phytoestrogen found naturally in bee propolis and various plant extracts. It possesses antioxidant, anti-inflammatory and anti-proliferative properties. The current study was conducted to explore the role chrysin plays in protection against testosterone-induced BPH in rats. On grounds of a preliminary experiment, a dose of chrysin (50 mg/kg) was...
6 CitationsSource
#1Amani E. Khalifa (Ain Shams University)H-Index: 17
Source
#1Haidy E. Michel (Ain Shams University)H-Index: 2
#2Mariane G. Tadros (Ain Shams University)H-Index: 11
Last.Ahmed M. Abdel-tawab (Ain Shams University)H-Index: 8
view all 5 authors...
Parkinson’s disease (PD) is a slowly progressive neurodegenerative movement disorder. Apoptosis, neuroinflammation, and oxidative stress are the current hypothesized mechanisms for PD pathogenesis. Tetramethylpyrazine (TMP), the major bioactive component of Ligusticum wallichii Franchat (ChuanXiong), Family Apiaceae, reportedly has anti-apoptotic, anti-inflammatory and antioxidant effects. This study investigated the role of ‘TMP’ in preventing rotenone-induced neurobiological and behavioral seq...
19 CitationsSource
#1Sara A. Wahdan (Ain Shams University)H-Index: 2
#2Mariane G. Tadros (Ain Shams University)H-Index: 11
Last.Amani E. Khalifa (Ain Shams University)H-Index: 17
view all 3 authors...
The present study was designed to investigate the neuroprotective effect of selegiline on 3-nitropropionic acid (3-NP)-induced neurotoxicity. Selegiline was intraperitoneally injected at doses 2.5, 5, and 10 mg/kg, 3 days prior to and continued daily, 30 min before 3-NP administration. 3-NP (20 mg/kg, i.p.) was administered for four consecutive days. 3-NP-treated rats exhibited PPI deficits, locomotor hypoactivity, increased striatal and cortical lipid peroxidation, and reduced respective glutat...
2 CitationsSource
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