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Agata Kabała-Dzik
University of Silesia in Katowice
33Publications
12H-index
343Citations
Publications 33
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#1Agata Kabała-Dzik (University of Silesia in Katowice)H-Index: 12
#2Anna Rzepecka-Stojko (University of Silesia in Katowice)H-Index: 7
Last.Jerzy Stojko (University of Silesia in Katowice)H-Index: 11
view all 6 authors...
Epithelium mammary carcinoma is a cancer with a high death rate among women. One factor having a significant impact on metastasis is cell migration. The aim of this study was to compare migration r...
3 CitationsSource
#1Agata Kabała-Dzik (University of Silesia in Katowice)H-Index: 12
#2Anna Rzepecka-Stojko (University of Silesia in Katowice)H-Index: 7
Last.Jerzy Stojko (University of Silesia in Katowice)H-Index: 11
view all 7 authors...
Breast cancer is one of the most common causes of mortality in women. Flavonoids, among other compounds, are bioactive constituents of propolis. In this comparative study, we investigated the effects of flavonoids apigenin (API), genistein (GEN), hesperidin (HES), naringin (NAR) and quercetin (QUE) on the proliferation, apoptosis, and cell cycle of two different human cancer cells - MDA-MB-231, estrogen-negative, and MCF-7, estrogen-positive receptor breast carcinoma cells. Many cytotoxic report...
7 CitationsSource
#2Agata Kabała-DzikH-Index: 12
Last.Jerzy StojkoH-Index: 11
view all 7 authors...
We have studied a preventive effect of polyphenol-rich bee pollen ethanol extract (EEP) against histological changes in the liver and cardiac blood vessels, abnormalities of lipid profile, and the levels of oxidized low density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) caused by a high-fat diet in C57BL6 mice. Supplementing the diet with EEP in the doses of 0.1 g/kg body mass (BM) and 1 g/kg BM resulted in a decrea...
2 CitationsSource
#1Agata Kabała-DzikH-Index: 12
Last.Jerzy StojkoH-Index: 11
view all 7 authors...
One of the deadliest cancers among women is a breast cancer. Research has shown that two natural substances occurring in propolis, caffeic acid (CA) and caffeic acid phenethyl ester (CAPE), have significant anticancer effects. The purpose of our in vitro study was to compare cytotoxic activity and migration rate inhibition using CA and CAPE (doses of 50 and 100 µm) against triple-negative, MDA-MB-231 breast adenocarcinoma line cells, drawn from Caucasian women. Viability was measured by XTT-NR-S...
12 CitationsSource
#1Marcello IritiH-Index: 35
#2Robert Kubina (University of Silesia in Katowice)H-Index: 12
Last.Robert D. Wojtyczka (University of Silesia in Katowice)H-Index: 10
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Several studies have documented the ability of flavonoids to sensitize cancer cells to chemotherapeutics and reverse multidrug resistance by inhibition of efflux pumps (adenosine triphosphate-binding cassette transporters), apoptosis activation, and cell cycle arrest. In this study, the flavonoid rutin (quercetin 3-O-β-d-rutinoside) was investigated as chemosensitizer towards two different human epithelial breast cancer cell lines: (i) MB-MDA-231, selected as representative for triple-negative b...
20 CitationsSource
#1Agata Kabała-DzikH-Index: 12
Last.Jerzy StojkoH-Index: 11
view all 7 authors...
Studies show that caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) are compounds with potent chemopreventive effects. Breast cancer is a common form of aggressive cancer among women worldwide. This study shows a comparison of CA and CAPE activity on triple-negative human caucasian breast adenocarcinoma line cells (MDA-MB-231). MDA-MB-231 cells were treated by CA and CAPE with doses of from 10 to 100 µM, for periods of 24 h and 48 h. Cytotoxicity MTT tests, apoptosis by Annexin V, and ce...
8 CitationsSource
Natural polyphenols have been observed to possess antiproliferative properties. The effects, including apoptotic potential of bioactive phenolic compounds, caffeic acid (CA) and its derivative caffeic acid phenethyl ester (CAPE), on cell proliferation and apoptosis in human head and neck squamous carcinoma cells (HNSCC) line (Detroit 562) were investigated and compared. Cancer cells apoptosis rates and cell cycle arrests were analysed by flow cytometry. Exposure to CA and CAPE was found to resul...
13 CitationsSource
#1Anna Rzepecka-Stojko (Medical University of Silesia)H-Index: 7
#2Jerzy Stojko (Medical University of Silesia)H-Index: 11
Last.Ewa Buszman (Medical University of Silesia)H-Index: 18
view all 8 authors...
Anna Rzepecka-Stojko 1,*, Jerzy Stojko 2,†, Anna Kurek-Gorecka 3,†, Michal Gorecki 4,†, Agata Kabala-Dzik 5,†, Robert Kubina 5,†, Aleksandra Moździerz 2,† and Ewa Buszman 1,† 1 Department of Pharmaceutical Chemistry, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Jagiellonska 4, Sosnowiec 41-200, Poland; ebuszman@sum.edu.pl 2 Department of Hygiene, Bioanalysis and Environmental Studies, School of Pharmacy with the Division of Laboratory Medicine, Medi...
Source
#2Jerzy StojkoH-Index: 11
Last.Ewa BuszmanH-Index: 18
view all 8 authors...
Bee pollen constitutes a natural source of antioxidants such as phenolic acids and flavonoids, which are responsible for its biological activity. Research has indicated the correlation between dietary polyphenols and cardioprotective, hepatoprotective, anti-inflammatory, antibacterial, anticancerogenic, immunostimulating, antianaemic effects, as well as their beneficial influence on osseous tissue. The beneficial effects of bee pollen on health result from the presence of phenolic acids and flav...
35 CitationsSource
#2Agata Kabała-DzikH-Index: 12
Last.Jerzy StojkoH-Index: 11
view all 11 authors...
Chemotherapy of breast cancer could be improved by bioactive natural substances, which may potentially sensitize the carcinoma cells’ susceptibility to drugs. Numerous phytochemicals, including propolis, have been reported to interfere with the viability of carcinoma cells. We evaluated the in vitro cytotoxic activity of ethanol extract of propolis (EEP) and its derivative caffeic acid phenethyl ester (CAPE) towards two triple-negative breast cancer (TNBC) cell lines, MDA-MB-231 and Hs578T, by i...
23 CitationsSource
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