Timothy Barrett
University of Birmingham
EndocrinologyType 2 diabetesDiabetes mellitusMedicineBiology
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Publications 262
#1Malgorzata Zatyka (University of Birmingham)H-Index: 17
#2Sovan Sarkar (University of Birmingham)H-Index: 41
Last. Timothy Barrett (University of Birmingham)H-Index: 54
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Abstract Neurodegenerative diseases (NDDs) comprise conditions with impaired neuronal function and loss, and may be associated with build-up of aggregated proteins with altered physicochemical properties (misfolded proteins). There are many disorders, and causes include gene mutations, infections, or exposure to toxins. The autophagy pathway is involved in the removal of unwanted proteins and organelles through lysosomes. While lysosomal storage disorders have been described for many years, it i...
1 CitationsSource
#1Elena Seranova (University of Birmingham)H-Index: 3
#2Adina Maria Palhegyi (University of Birmingham)
Last. Dhiraj Kumar (International Centre for Genetic Engineering and Biotechnology)H-Index: 17
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Abstract Autophagy is an intracellular degradation process that is essential for cellular survival, tissue homeostasis and human health. The housekeeping functions of autophagy in mediating the clearance of aggregation-prone proteins and damaged organelles are vital for post-mitotic neurons. Improper functioning of this process contributes to the pathology of myriad human diseases including neurodegeneration. Impairment in autophagy has been reported in several neurodegenerative diseases where p...
1 CitationsSource
#1Timothy BarrettH-Index: 54
#2Muhammad Yazid Jalaludin (UM: University of Malaya)H-Index: 11
Last. Naim ShehadehH-Index: 22
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Type 2 diabetes (T2D) is suggested to progress faster in children and young people vs type 1 diabetes (T1D) in the same age group and T2D in adults. We reviewed the evidence base for this. A literature search was performed of PubMed-indexed publications between 2000 and 2018, for the terms "pediatric" and "T2D." Results were combined and filtered for those relating to "progression." Searches of abstract books from Latin American and Asian congresses were performed to include these populations. P...
Wolfram syndrome is a rare genetic, progressive, neurodegenerative disorder characterised by childhood-onset diabetes mellitus, diabetes insipidus, optic atrophy and deafness. To date, the economic burden of Wolfram syndrome has not been well-studied or reported. The aim of this study was to evaluate the cost of illness (COI) of all people with Wolfram syndrome in the UK and to identify major determinants of cost from a service provider perspective (National Health Service, NHS). A prevalence-ba...
#1Hakan CangulH-Index: 9
#2Xiao Hui LiaoH-Index: 30
Last. Nadia SchoenmakersH-Index: 17
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4 CitationsSource
#1Michael ColeH-Index: 27
#2Ann Marie HynesH-Index: 10
Last. Tim CheethamH-Index: 33
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#1Hakan CangulH-Index: 9
#2Xiao Hui LiaoH-Index: 30
Last. Erdal ErenH-Index: 9
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view all 16 authors...
Abstract Background Metformin is the regulatory-approved treatment of choice for most youth with type 2 diabetes early in the disease. However, early loss of glycemic control has been observed with...
5 CitationsSource
#1Elizabeth S. Baranowski (University of Birmingham)H-Index: 3
#2Timothy Barrett (University of Birmingham)H-Index: 54
Abstract Metabolic syndrome comprises the association of risk factors for future cardiovascular disease (hypertension, altered glucose metabolism, dyslipidaemia, and abdominal obesity). It is thought to affect up to 40% of overweight or obese children in the UK. This has coincided with a rise in obesity-related type 2 diabetes in children. The characterisation of co-morbidities has improved since the last review in 2015. This review discusses some of the current theories about disease mechanisms...