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Thorfinn Sand Korneliussen
University of Copenhagen
PopulationAllele frequencyGeneticsPopulation geneticsBiology
60Publications
34H-index
5,902Citations
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Publications 62
Newest
#1Moreno-Mayar Jv (Swiss Institute of Bioinformatics)
#1J. Víctor Moreno-Mayar (Swiss Institute of Bioinformatics)H-Index: 14
Last. Anna-Sapfo Malaspinas (Swiss Institute of Bioinformatics)H-Index: 23
view all 7 authors...
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#1Ashot Margaryan (UCPH: University of Copenhagen)H-Index: 12
#2Daniel J. Lawson (UoB: University of Bristol)H-Index: 46
Last. Eske WillerslevH-Index: 94
view all 85 authors...
The Viking maritime expansion from Scandinavia (Denmark, Norway, and Sweden) marks one of the swiftest and most far-flung cultural transformations in global history. During this time (c. 750 to 1050 CE), the Vikings reached most of western Eurasia, Greenland, and North America, and left a cultural legacy that persists till today. To understand the genetic structure and influence of the Viking expansion, we sequenced the genomes of 442 ancient humans from across Europe and Greenland ranging from ...
2 CitationsSource
#1Line SkotteH-Index: 9
#2Emil JørsboeH-Index: 3
Last. Anders AlbrechtsenH-Index: 47
view all 5 authors...
2 CitationsSource
#1Gabriel Renaud (UCPH: University of Copenhagen)H-Index: 26
#2Kristian Hanghøj (UCPH: University of Copenhagen)H-Index: 9
Last. Ludovic Orlando (UCPH: University of Copenhagen)H-Index: 57
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Both the total amount and the distribution of heterozygous sites within individual genomes are informative about the genetic diversity of the population they belong to. Detecting true heterozygous sites in ancient genomes is complicated by the generally limited coverage achieved and the presence of post-mortem damage inflating sequencing errors. Additionally, large runs of homozygosity found in the genomes of particularly inbred individuals and of domestic animals can skew estimates of genome-wi...
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#1Kristian Hanghøj (University of Toulouse)H-Index: 9
#2Ida Moltke (UCPH: University of Copenhagen)H-Index: 27
Last. Thorfinn Sand Korneliussen (University of Cambridge)H-Index: 34
view all 5 authors...
1 CitationsSource
#1J. Víctor Moreno-Mayar (Swiss Institute of Bioinformatics)H-Index: 14
#2Thorfinn Sand Korneliussen (UCPH: University of Copenhagen)H-Index: 34
Last. Anna-Sapfo Malaspinas (Swiss Institute of Bioinformatics)H-Index: 23
view all 7 authors...
The presence of present-day human contaminating DNA fragments is one of the challenges defining ancient DNA (aDNA) research. This is especially relevant to the ancient human DNA field where it is difficult to distinguish endogenous molecules from human contaminants due to their genetic similarity. Recently, with the advent of high-throughput sequencing and new aDNA protocols, hundreds of ancient human genomes have become available. Contamination in those genomes has been measured with computatio...
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#1Ana Prohaska (University of Cambridge)H-Index: 4
#2Fernando Racimo (Wild Center)H-Index: 23
Last. Eske Willerslev (University of Cambridge)H-Index: 94
view all 16 authors...
Identifying the causes of similarities and differences in genetic disease prevalence among humans is central to understanding disease etiology. While present-day humans are not strongly differentiated, vast amounts of genomic data now make it possible to study subtle patterns of genetic variation. This allows us to trace our genomic history thousands of years into the past and its implications for the distribution of disease-associated variants today. Genomic analyses have shown that demographic...
4 CitationsSource
#1Peter de Barros Damgaard (UCPH: University of Copenhagen)H-Index: 12
#2Nina Marchi (University of Paris)
Last. Emma UsmanovaH-Index: 10
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Source
#1Peter de Barros Damgaard (UCPH: University of Copenhagen)H-Index: 12
#2Nina Marchi (University of Paris)
Last. Emma UsmanovaH-Index: 10
view all 77 authors...
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#1Siyang Liu (UCPH: University of Copenhagen)H-Index: 10
#2Shujia Huang (SCUT: South China University of Technology)H-Index: 8
Last. Xun XuH-Index: 67
view all 38 authors...
Summary We analyze whole-genome sequencing data from 141,431 Chinese women generated for non-invasive prenatal testing (NIPT). We use these data to characterize the population genetic structure and to investigate genetic associations with maternal and infectious traits. We show that the present day distribution of alleles is a function of both ancient migration and very recent population movements. We reveal novel phenotype-genotype associations, including several replicated associations with he...
31 CitationsSource
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