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Kamaruddin Mohd Yusoff
Canik Başarı University
AntioxidantLipopolysaccharideNitric oxideBiochemistryBiology
20Publications
12H-index
804Citations
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Publications 20
Newest
#1Sangu MuthurajuH-Index: 12
#2Mohammad Rafiqul Islam (Universiti Sains Malaysia)H-Index: 2
Last. Kamaruddin Mohd Yusoff (Canik Başarı University)H-Index: 12
view all 6 authors...
Dopamine (DA) is one of the key neurotransmitters in the striatum, which is functionally important for a variety of cognitive and motor behaviours. It is known that the striatum is vulnerable to damage from traumatic brain injury (TBI). However, a therapeutic approach has not yet been established to treat TBI. Hence, the present work aimed to evaluate the ability of Normobaric hyperoxia treatment (NBOT) to recover dopaminergic neurons following a fluid percussion injury (FPI) as a TBI experiment...
2 CitationsSource
#1Mustafa Kassim (UM: University of Malaya)H-Index: 7
#2Marzida MansorH-Index: 11
Last. Kamaruddin Mohd YusoffH-Index: 12
view all 10 authors...
Excessive free radical production by immune cells has been linked to cell death and tissue injury during sepsis. Peroxynitrite is a short-lived oxidant and a potent inducer of cell death that has been identified in several patho- logical conditions. Caffeic acid phenethyl ester (CAPE) is an active component of honeybee products and exhibits anti- oxidant, anti-inflammatory, and immunomodulatory activities. The present study examined the ability of CAPE to scavenge peroxynitrite in RAW 264.7 muri...
8 CitationsSource
To examine, for the first time, the effect of a selected Malaysian honey and its major components on the proliferation of cultured fibroblasts. Materials and methods: Honey and some of its components, which include the sugars, the proteins, the hydrogen peroxide produced, and the phenolics, were exposed to cultured fibroblasts. The MTT colorimetric assay was used to assess cell viability and proliferation. Results: The stimulatory effect of honey on fibroblast proliferation was observed to be ti...
5 CitationsSource
#1Saba Zuhair Hussein (UKM: National University of Malaysia)H-Index: 5
#2Kamaruddin Mohd Yusoff (Canik Başarı University)H-Index: 12
Last. Mohd Yusof Ya (Canik Başarı University)H-Index: 2
view all 4 authors...
Honey is a supersaturated solution of sugars, enriched with proteins, minerals, vitamins, organic acids and polyphenols. Gamma irradiation is a physical technique of food preservation which protects the honey from insects' and microbial contamination during storage. We investigated the effect of gamma irradiation on physicochemical properties in two types of Malaysian honey, Gelam and Nenas.Both honeys were irradiated at the dose 25 kGy in a cobalt-60 irradiator. The physicochemical properties p...
8 CitationsSource
#1Saba Zuhair Hussein (UKM: National University of Malaysia)H-Index: 5
#2Kamaruddin Mohd Yusoff (Canik Başarı University)H-Index: 12
Last. Yasmin Anum Mohd Yusof (UKM: National University of Malaysia)H-Index: 20
view all 4 authors...
The activation of nuclear factor kappa B (NF-κB) plays a major role in the pathogenesis of a number of inflammatory diseases. In this study, we investigated the anti-inflammatory mechanism of Gelam honey in inflammation induced rats via NF-κB signalling pathway. Rats paw edema was induced by subplantar injection of 1% carrageenan into the right hind paw. Rats were pre-treated with Gelam honey at different doses (1 or 2 g/kg, p.o.) and NSAID Indomethacin (10 mg/kg, p.o.), in two time points (1 an...
27 CitationsSource
#1Mohd Izwan Zainol (UM: University of Malaya)H-Index: 1
#2Kamaruddin Mohd Yusoff (Canik Başarı University)H-Index: 12
Last. Mohd Yasim Mohd Yusof (UM: University of Malaya)H-Index: 14
view all 3 authors...
Background Antibacterial activity of honey is mainly dependent on a combination of its peroxide activity and non-peroxide components. This study aims to investigate antibacterial activity of five varieties of Malaysian honey (three monofloral; acacia, gelam and pineapple, and two polyfloral; kelulut and tualang) against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Pseudomonas aeruginosa.
44 CitationsSource
#1Mustafa KassimH-Index: 7
#2Marzida Mansor (UM: University of Malaya)H-Index: 11
Last. Kamaruddin Mohd YusoffH-Index: 12
view all 5 authors...
Monocytes and macrophages are part of the first-line defense against bacterial, fungal, and viral infections during host immune responses; they express high levels of proinflammatory cytokines and cytotoxic molecules, including nitric oxide, reactive oxygen species, and their reaction product peroxynitrite. Peroxynitrite is a short-lived oxidant and a potent inducer of cell death. Honey, in addition to its well-known sweetening properties, is a natural antioxidant that has been used since ancien...
6 CitationsSource
#1Mustafa Kassim (UM: University of Malaya)H-Index: 7
#2Kamaruddin Mohd Yusoff (Canik Başarı University)H-Index: 12
Last. Marzida Mansor (UM: University of Malaya)H-Index: 11
view all 6 authors...
Abstract Malaysian Gelam honey has anti-inflammatory and antibacterial properties, a high antioxidant capacity, and free radical-scavenging activity. Lipopolysaccharide (LPS) stimulates immune cells to sequentially release early pro- and anti-inflammatory cytokines and induces the synthesis of several related enzymes. The aim of this study was to investigate the effect of the intravenous injection of honey in rats with LPS-induced endotoxemia. The results showed that after 4 h of treatment, hone...
30 CitationsSource
#2Kamaruddin Mohd Yusoff (Canik Başarı University)H-Index: 12
Last. Yasmin Anum Mohd YusofH-Index: 20
view all 4 authors...
Natural honey is well known for its therapeutic value and has been used in traditional medicine of different cultures throughout the world. The aim of this study was to investigate the anti-inflammatory effect of Malaysian Gelam honey in inflammation-induced rats. Paw edema was induced by a subplantar injection of 1% carrageenan into the rat right hind paw. Rats were treated with the nonsteroidal anti-inflammatory drug (NSAID) Indomethacin (10 mg/kg, p.o.) or Gelam honey at different doses (1 or...
58 CitationsSource
Gelam honey exerts anti-inflammatory and antioxidant activities and is thought to have potent effects in reducing infections and healing wounds. The aim of this study was to investigate the effects of intravenously-injected Gelam honey in protecting organs from lethal doses of lipopolysaccharide (LPS). Six groups of rabbits (N = 6) were used in this study. Two groups acted as controls and received only saline and no LPS injections. For the test groups, 1 mL honey (500 mg/kg in saline) was intrav...
20 CitationsSource
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