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Gary K. Shooter
Queensland University of Technology
41Publications
8H-index
375Citations
Publications 41
Newest
Published on Jul 1, 2016in Molecular Cancer Therapeutics 4.86
Abhishek S. Kashyap5
Estimated H-index: 5
(QUT: Queensland University of Technology),
Gary K. Shooter8
Estimated H-index: 8
(QUT: Queensland University of Technology)
+ 8 AuthorsZee Upton31
Estimated H-index: 31
(QUT: Queensland University of Technology)
We provide proof-of-concept evidence for a new class of therapeutics which target growth factor:extracellular matrix (GF:ECM) interactions for the management of breast cancer. Insulin-like growth factor-I (IGF-I) forms multi-protein complexes with IGF-binding proteins (IGFBP) and the ECM protein vitronectin (VN), and stimulates the survival, migration and invasion of breast cancer cells. For the first time we provide physical evidence for IGFBP-3:VN interactions in breast cancer patient tissues;...
1 Citations Source Cite
Published on Apr 1, 2015in International Wound Journal 2.38
Gary K. Shooter8
Estimated H-index: 8
(QUT: Queensland University of Technology),
Derek R. Van Lonkhuyzen8
Estimated H-index: 8
(QUT: Queensland University of Technology)
+ 6 AuthorsZee Upton31
Estimated H-index: 31
(QUT: Queensland University of Technology)
The majority of the population experience successful wound-healing outcomes; however, 1-3% of those aged over 65 years experience delayed wound healing and wound perpetuation. These hard-to-heal wounds contain degraded and dysfunctional extracellular matrix (ECM); yet, the integrity of this structure is critical in the processes of normal wound healing. Here, we evaluated a novel synthetic matrix protein for its ability to act as an acellular scaffold that could replace dysfunctional ECM. In thi...
4 Citations Source Cite
Published on Jan 1, 2015
Gary K. Shooter8
Estimated H-index: 8
,
Tristan I. Croll14
Estimated H-index: 14
+ 6 AuthorsZee Upton31
Estimated H-index: 31
Dermal wound healing is a biochemical and cellular process critical to life. While the majority of the population will only ever experience successful wound healing outcomes, some 1-3 % of those aged over 65 years will experience wound healing delay or perpetuation. These hard-to-heal wounds are comprised of degraded and dysfunctional extracellular matrix, yet the integrity of this structure is critical in the processes of normal wound healing. As such, extracellular matrix replacements have bee...
Published on Jan 1, 2015
Keith Gordon Harding55
Estimated H-index: 55
,
Pat Aldons1
Estimated H-index: 1
+ 9 AuthorsEmily Lynam5
Estimated H-index: 5
Hard-to-heal leg ulcers are a major cause of morbidity in the elderly population. Despite improvements in wound care, some wounds will not heal and they present a significant challenge for patients and health care providers. A multi-centre cohort study was conducted to evaluate the effectiveness and safety of a synthetic, extracellular matrix protein as an adjunct to standard care in the treatment of hard-to-heal venous or mixed leg ulcers. Primary effectiveness criteria were (i) reduction in wo...
Published on Jan 1, 2013in Amino Acids 2.52
Manaswini Sivaramakrishnan6
Estimated H-index: 6
(QUT: Queensland University of Technology),
Gary K. Shooter8
Estimated H-index: 8
(QUT: Queensland University of Technology)
+ 1 AuthorsTristan I. Croll14
Estimated H-index: 14
(QUT: Queensland University of Technology)
Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling. We cite literature that confirms and suggests the formation of integrin:RTK:transglutaminase complexes and explores the occurrence and functionality of these complexes in a large f...
8 Citations Source Cite
Published on Jan 1, 2012
Daniel Broszczak4
Estimated H-index: 4
,
Dario Stupar2
Estimated H-index: 2
+ 5 AuthorsMelissa Laura Fernandez4
Estimated H-index: 4
The lack of fundamental knowledge on the biological processes associated with wound healing represents a significant challenge. Understanding the biochemical changes that occur within a chronic wound could provide insights into the wound environment and enable more effective wound management. We report on the stability of wound fluid samples under various conditions and describe a high-throughput approach to investigate the altered biochemical state within wound samples collected from various ty...
6 Citations
Published on Jan 1, 2012
Dario Stupar2
Estimated H-index: 2
,
Tony J. Parker6
Estimated H-index: 6
+ 2 AuthorsMelissa L. Fernandez1
Estimated H-index: 1
Published on Jan 1, 2010
Yang Cao9
Estimated H-index: 9
,
Tristan I. Croll14
Estimated H-index: 14
+ 2 AuthorsTim R. Dargaville21
Estimated H-index: 21
During wound repair, the balance between matrix metalloproteinases (MMPs) and their natural inhibitors (the TIMPs) is crucial for the normal extra cellular matrix turnover. However, the over expression of several MMPs including MMP-1, 2, 3, 8, 9 and MMP-10, combined with abnormally high levels of activation or low expression of TIMPs, may contribute to excessive degradation of connective tissue and formation of chronic ulcers. There are many groups exploring strategies for promoting wound healin...
12