Gary K. Shooter
Queensland University of Technology
40Publications
8H-index
369Citations
Publications 40
Newest
Published on Jul 1, 2016in Molecular Cancer Therapeutics 5.37
Abhishek S. Kashyap4
Estimated H-index: 4
(Queensland University of Technology),
Gary K. Shooter8
Estimated H-index: 8
(Queensland University of Technology)
+ 8 AuthorsZee Upton29
Estimated H-index: 29
(Queensland University of Technology)
We provide proof-of-concept evidence for a new class of therapeutics which target growth factor:extracellular matrix (GF:ECM) interactions for the management of breast cancer. Insulin-like growth factor-I (IGF-I) forms multi-protein complexes with IGF-binding proteins (IGFBP) and the ECM protein vitronectin (VN), and stimulates the survival, migration and invasion of breast cancer cells. For the first time we provide physical evidence for IGFBP-3:VN interactions in breast cancer patient tissues;...
1 Citations Source Cite
Published on Apr 1, 2015in International Wound Journal 2.38
Gary K. Shooter8
Estimated H-index: 8
(Queensland University of Technology),
Derek R. Van Lonkhuyzen8
Estimated H-index: 8
(Queensland University of Technology)
+ 6 AuthorsZee Upton29
Estimated H-index: 29
(Queensland University of Technology)
The majority of the population experience successful wound-healing outcomes; however, 1-3% of those aged over 65 years experience delayed wound healing and wound perpetuation. These hard-to-heal wounds contain degraded and dysfunctional extracellular matrix (ECM); yet, the integrity of this structure is critical in the processes of normal wound healing. Here, we evaluated a novel synthetic matrix protein for its ability to act as an acellular scaffold that could replace dysfunctional ECM. In thi...
3 Citations Source Cite
Published on Apr 1, 2014in International Wound Journal 2.38
Keith Gordon Harding52
Estimated H-index: 52
(Cardiff University),
Pat Aldons1
Estimated H-index: 1
+ 9 AuthorsEmily Lynam5
Estimated H-index: 5
(Queensland University of Technology)
Hard-to-heal leg ulcers are a major cause of morbidity in the elderly population. Despite improvements in wound care, some wounds will not heal and they present a significant challenge for patients and health care providers. A multi-centre cohort study was conducted to evaluate the effectiveness and safety of a synthetic, extracellular matrix protein as an adjunct to standard care in the treatment of hard-to-heal venous or mixed leg ulcers. Primary effectiveness criteria were (i) reduction in wo...
6 Citations Source Cite
Published on Feb 1, 2014in Current Rheumatology Reports 3.08
Melissa Laura Fernandez3
Estimated H-index: 3
(Queensland University of Technology),
Zee Upton29
Estimated H-index: 29
(Queensland University of Technology),
Gary K. Shooter8
Estimated H-index: 8
(Queensland University of Technology)
Chronic wounds are an important health problem because they are difficult to heal and treatment is often complicated, lengthy and expensive. For a majority of sufferers the most common outcomes are long-term immobility, infection and prolonged hospitalisation. There is therefore an urgent need for effective therapeutics that will enhance ulcer healing and patient quality of life, and will reduce healthcare costs. Studies in our laboratory have revealed elevated levels of purine catabolites in wo...
7 Citations Source Cite
Published on Jan 1, 2013in Amino Acids 2.91
Manaswini Sivaramakrishnan5
Estimated H-index: 5
(Queensland University of Technology),
Gary K. Shooter8
Estimated H-index: 8
(Queensland University of Technology)
+ 1 AuthorsTristan I. Croll14
Estimated H-index: 14
(Queensland University of Technology)
Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling. We cite literature that confirms and suggests the formation of integrin:RTK:transglutaminase complexes and explores the occurrence and functionality of these complexes in a large f...
8 Citations Source Cite
Published on Dec 1, 2013in Biochimica et Biophysica Acta 3.44
Manaswini Sivaramakrishnan5
Estimated H-index: 5
(Queensland University of Technology),
Tristan I. Croll14
Estimated H-index: 14
(Queensland University of Technology)
+ 4 AuthorsGary K. Shooter8
Estimated H-index: 8
(Queensland University of Technology)
Numerous studies have reported associations between IGF-I and other extra cellular matrix (ECM) proteins, including fibronectin (FN), integrins, IGF-binding proteins (IGFBPs) and through IGFBPs, with vitronectin (VN). Nevertheless, the precise nature and mechanisms of these interactions are still being characterised. In this paper, we discuss transglutaminases (TGases) as a constituent of the ECM and provide evidence for the first time that IGF-I is a lysine (K)-donor substrate to TGases. When I...
2 Citations Source Cite
Published on Apr 1, 2012in International Wound Journal 2.38
Melissa Laura Fernandez3
Estimated H-index: 3
(Queensland University of Technology),
Zee Upton29
Estimated H-index: 29
(Queensland University of Technology)
+ 2 AuthorsGary K. Shooter8
Estimated H-index: 8
(Queensland University of Technology)
Chronic venous leg ulcers are a major health issue and represent an often overlooked area of biomedical research. Nevertheless, it is becoming increasingly evident that new approaches to enhance healing outcomes may arise through better understanding the processes involved in the formation of chronic wounds. We have for the first time shown that the terminal purine catabolite uric acid (UA) is elevated in wound fluid (WF) from chronic venous leg ulcers with relative concentrations correlating wi...
24 Citations Source Cite
Published on Mar 15, 2011in Journal of Biomedical Materials Research Part A 3.23
Yang Cao9
Estimated H-index: 9
(Queensland University of Technology),
Tristan I. Croll14
Estimated H-index: 14
(Queensland University of Technology)
+ 5 AuthorsTim R. Dargaville20
Estimated H-index: 20
(Queensland University of Technology)
Successful wound repair and normal turnover of the extracellular matrix relies on a balance between matrix metalloproteinases (MMPs) and their natural tissue inhibitor of metalloproteinases (TIMPs). When overexpression of MMPs and abnormally high levels of activation or low expression of TIMPs are encountered, excessive degradation of connective tissue and the formation of chronic ulcers can occur. One strategy to rebalance MMPs and TIMPs is to use inhibitors. We have designed a synthetic pseudo...
11 Citations Source Cite
Published on Oct 1, 2011in International Wound Journal 2.38
Zee Upton29
Estimated H-index: 29
(Queensland University of Technology),
Hilary J. Wallace10
Estimated H-index: 10
(University of Western Australia)
+ 9 AuthorsR. Gary Sibbald28
Estimated H-index: 28
(University of Toronto)
Several different advanced treatments have been used to improve healing in chronic wounds, but none have shown sustained success. The application of topical growth factors (GFs) has displayed some potential, but the varying results, high doses and high costs have limited their widespread adoption. Many treatments have ignored the evidence that wound healing is driven by interactions between extracellular matrix proteins and GFs, not just GFs alone. We report herein that a clinical Good Manufactu...
25 Citations Source Cite
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