Meryl E. Wastney
Georgetown University Medical Center
Publications 86
#1Meryl E. WastneyH-Index: 25
#2Christine M. McDonald (Children's Hospital Oakland Research Institute)H-Index: 1
Last.Janet C. King (Children's Hospital Oakland Research Institute)H-Index: 48
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BACKGROUND: The bioavailability of potassium should be considered in setting requirements, but to our knowledge, the bioavailability from individual foods has not been determined. Potatoes provide 19-20% of potassium in the American diet. OBJECTIVE: We compared the bioavailability and dose response of potassium from nonfried white potatoes with skin [targeted at 20, 40, and 60 milliequivalents (mEq) K] and French fries (40 mEq K) with potassium gluconate at the same doses when added to a basal d...
4 CitationsSource
#1Scott M. SmithH-Index: 33
#2Carmen Castaneda-Sceppa (NU: Northeastern University)H-Index: 21
Last.Meryl E. WastneyH-Index: 25
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Summary We assessed the potential for countermeasures to lessen the loss of bone calcium during bed rest. Subjects ingested less calcium during bed rest, and with artificial gravity, they also absorbed less calcium. With exercise, they excreted less calcium. To retain bone during bed rest, calcium intake needs to be maintained.
7 CitationsSource
#1Scott M. SmithH-Index: 33
#2Steven A. Abrams (University of Texas at Austin)H-Index: 57
Last.Sara R. Zwart (USRA: Universities Space Research Association)H-Index: 24
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Calcium and bone metabolism remain key concerns for space travelers, and ground-based models of space flight have provided a vast literature to complement the smaller set of reports from flight studies. Increased bone resorption and largely unchanged bone formation result in the loss of calcium and bone mineral during space flight, which alters the endocrine regulation of calcium metabolism. Physical, pharmacologic, and nutritional means have been used to counteract these changes. In 2012, heavy...
43 CitationsSource
#1Alyssa PhillipsH-Index: 1
#2Berdine R. MartinH-Index: 35
Last.Connie M. WeaverH-Index: 64
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Concern over calcium supplementation for elevating risk of cardiovascular disease has led to a calcium controversy because calcium is a shortfall essential nutrient. Understanding cardiovascular ri...
1 Citations
#1Corrie M. Whisner (Purdue University)H-Index: 7
#2Berdine R. Martin (Purdue University)H-Index: 35
Last.Connie M. Weaver (Purdue University)H-Index: 64
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Adolescence is a time for rapid growth that represents an opportunity to influence peak bone mass. Prebiotic agents, such as galacto-oligosaccharides (GOS), increase Ca absorption in animal models and postmenopausal women. The objectives of the present study were to investigate the dose-response relationship of GOS supplementation on Ca absorption during growth and to assess changes in colonic microbiota to better understand the mechanism by which GOS is acting. A total of thirty-one healthy ado...
89 CitationsSource
#1Kathleen M. Hill (IU: Indiana University)H-Index: 7
#2Berdine R. Martin (Purdue University)H-Index: 35
Last.Munro Peacock (IU: Indiana University)H-Index: 69
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Patients with chronic kidney disease (CKD) are given calcium carbonate to bind dietary phosphorus, reduce phosphorus retention, and prevent negative calcium balance; however, data are limited on calcium and phosphorus balance during CKD to support this. Here, we studied eight patients with stage 3 or 4 CKD (mean estimated glomerular filtration rate 36ml/min) who received a controlled diet with or without a calcium carbonate supplement (1500mg/day calcium) during two 3-week balance periods in a r...
139 CitationsSource
To assess the potential for artificial gravity (AG) and exercise (EX) to mitigate the effects of bone loss during space flight, we performed two studies: (1) a 21-d bed rest (BR) with subjects rece...
#1Qinmin Zhang (Purdue University)H-Index: 2
#2Meryl E. WastneyH-Index: 25
Last.Connie M. Weaver (Purdue University)H-Index: 64
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Calcium retention varies with developmental state, which may be partially under the control of insulin-like growth factor 1 (IGF-1). IGF-1 levels can be manipulated through dietary and therapeutic interventions. We investigated the relationship between IGF-1 endogenous production and calcium utilization and bone accretion during growth as well as the effects of IGF-1 treatment on calcium utilization during rapid and slowed growth in intact female Sprague-Dawley rats. In 33 rats killed at 11 time...
10 CitationsSource