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Igor Nenadic
University of Marburg
PsychiatryDevelopmental psychologyPsychologyNeuroscienceSchizophrenia
101Publications
25H-index
5,606Citations
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Publications 72
Newest
#1Robert SpalthoffH-Index: 3
#2Franziska Degenhardt (University of Bonn)H-Index: 32
Last. Igor Nenadic (Phillips University)H-Index: 23
view all 9 authors...
Abstract We tested whether a polygenic risk score integrating the effects of genes affecting neurodevelopment is associated to brain structural variation in healthy subjects. We acquired magnetic resonance imaging and genetic data of 167 healthy adults and computed a neurodevelopmental polygenic risk score (nPRS). We correlated the nPRS with local gyrification, cortical thickness and grey matter density and explored effects of single nucleotide polymorphisms included in the score. We did not fin...
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#2Ulrich EttingerH-Index: 41
Last. Igor NenadicH-Index: 25
view all 4 authors...
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#1Robert SpalthoffH-Index: 3
#2Christian GaserH-Index: 61
Last. Igor Nenadic (Phillips University)H-Index: 23
view all 3 authors...
Abstract Schizophrenia is modelled as a neurodevelopmental disease with high heritability. However, established markers like cortical thickness and grey matter volume are heavily influenced by post-onset changes and thus provide limited possibility of accessing early pathologies. Gyrification on the other side is assumed to be more specifically determined by genetic and early developmental factors. Here, we compare T1 weighted 3 Tesla MRI scans of 51 schizophrenia patients and 102 healthy contro...
4 CitationsSource
#1Guiyan Ni (UniSA: University of South Australia)H-Index: 4
#2Jacob Gratten (UQ: University of Queensland)H-Index: 26
Last. Michael O. Donovan (Cardiff University)H-Index: 122
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Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to esti...
7 CitationsSource
#1Matthias KarraschH-Index: 9
#2Volker FingerleH-Index: 40
Last. Igor Nenadic (Phillips University)H-Index: 23
view all 7 authors...
Abstract We report the case of an 80-year-old patient with acute onset confusion initially suspected to reflect delirium in incipient Alzheimer’s disease. Cerebrospinal fluid tests revealed an unusually severe form of neuroborreliosis, which resolved following antibiotic treatment. This was mirrored in the measurement of CXCL13, which is suggested as a complementary biomarker. Clinical implications for screening, differential diagnosis and treatment are discussed.
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#1Igor Nenadic (FSU: University of Jena)H-Index: 25
#2Sina Lamberth (Goethe University Frankfurt)H-Index: 1
Last. Neele Reiss (Goethe University Frankfurt)H-Index: 6
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Abstract Group schema therapy (GST) has been proposed as a novel long-term treatment programme for borderline and cluster C personality disorders. We implemented a short-term GST programme (12–15 sessions, based on the manual by Farrell and Shaw (2012), including both cognitive / behavioural and experiential interventions for in-patients (n=9) with either borderline or cluster C personality disorders (and axis I co-morbidities) treated in a (sub)acute psychiatric in-patient setting. We evaluated...
3 CitationsSource
#1Russell L. McLaughlin (Trinity College, Dublin)H-Index: 22
#2Dick Schijven (UU: Utrecht University)H-Index: 3
Last. Michael O. Donovan (Cardiff University)H-Index: 122
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We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4...
42 CitationsSource
#1Eilis Hannon (University of Exeter)H-Index: 20
#2Emma Dempster (University of Exeter)H-Index: 27
Last. Jonathan Mill (University of Exeter)H-Index: 60
view all 24 authors...
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by episodic psychosis and altered cognitive function. Despite success in identifying genetic variants associated with schizophrenia, there remains uncertainty about the causal genes involved in disease pathogenesis and how their function is regulated.
104 CitationsSource
#1Eilis HannonH-Index: 20
Last. Jonathan MillH-Index: 60
view all 24 authors...
#1Eilis HannonH-Index: 20
Last. Jonathan MillH-Index: 60
view all 24 authors...
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