Wouter J. de Jonge
University of Amsterdam
Publications 146
Irritable bowel syndrome (IBS) is a heterogenic, functional gastrointestinal disorder of the gut-brain axis characterized by altered bowel habit and abdominal pain. Preclinical and clinical results suggested that, in part of these patients, pain may result from fungal induced release of mast cell derived histamine, subsequent activation of sensory afferent expressed histamine-1 receptors and related sensitization of the nociceptive transient reporter potential channel V1 (TRPV1)-ion channel. TRP...
#1Rose Willemze (UvA: University of Amsterdam)H-Index: 3
#2Olaf Welting (UvA: University of Amsterdam)H-Index: 10
Last.Wouter J. de Jonge (UvA: University of Amsterdam)H-Index: 27
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Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to investigate the role of sympathetic innervation to the intestine on regulation of the innate immune responses. In lipopolysaccharide (LPS)-stimulated macrophages, we evaluated the effect of adrenergic receptor activation on cytokine production and metabolic profile. In vivo, the effect of sympath...
3 CitationsSource
#1Rose Willemze (UvA: University of Amsterdam)H-Index: 3
#2David J. Brinkman (UvA: University of Amsterdam)H-Index: 4
Last.Wouter J. de Jonge (University of Bonn)H-Index: 27
view all 9 authors...
Clinical trials suggest that vagus nerve stimulation presents an alternative approach to classical immune suppression in Crohn's disease. T-cells capable of producing acetylcholine (ChAT+T-cells) i...
Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells. Since histone deacetylase protein inhibitors demonstrate profound anti-inflammatory activity, we wanted to test whether HDAC inhibition within monocytes and macrophages could be applied to suppress inflammation in vivo. ESM technology conjugates an esterase-sensitive motif (ESM) onto small molecules to allo...
#1Manon de Krijger (UvA: University of Amsterdam)H-Index: 2
#2M.E. Wildenberg (UvA: University of Amsterdam)H-Index: 8
Last.Cyriel Y. Ponsioen (UvA: University of Amsterdam)H-Index: 42
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Summary Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tree, characterised by stricturing bile duct disease and progression to liver fibrosis. The pathophysiology of PSC is still unknown. The concurrence with inflammatory bowel disease (IBD) in about 70% of cases has led to the hypothesis that gut-homing lymphocytes aberrantly traffic to the liver, contributing to disease pathogenesis in patients with both PSC and IBD (PSC-IBD). The discovery of mutual trafficking...
1 CitationsSource
#1David J. BrinkmanH-Index: 4
#2Anne S. ten HoveH-Index: 1
Last.Wouter J. de JongeH-Index: 27
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Inflammatory bowel diseases (IBD) have a complex, multifactorial pathophysiology with an unmet need for effective treatment. This calls for novel strategies to improve disease outcome and quality of life for patients. Increasing evidence suggests that autonomic nerves and neurotransmitters, as well as neuropeptides, modulate the intestinal immune system, and thereby regulate the intestinal inflammatory processes. Although the autonomic nervous system is classically divided in a sympathetic and p...
#1Rose WillemzeH-Index: 3
#2David J. BrinkmanH-Index: 4
Last.Wouter J. de JongeH-Index: 27
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#1Mohammed GhiboubH-Index: 1
#2Nicola R. HarkerH-Index: 1
Last.Wouter J. de JongeH-Index: 27
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#1James D. LewisH-Index: 76
#2Sam E. MasonH-Index: 8
Last.James KinrossH-Index: 28
view all 10 authors...
#1Gun-Soo Hong (University of Bonn)H-Index: 3
#2Anne Zillekens (University of Bonn)H-Index: 1
Last.Sven Wehner (University of Bonn)H-Index: 18
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Background: The cholinergic anti-inflammatory pathway comprises the perception of peripheral inflammation by afferent sensory neurons and reflex activation of efferent vagus nerve activity to regulate inflammation. Activation of this pathway was shown to reduce the inflammatory response and improve outcome of postoperative ileus (POI) and sepsis in rodents. Herein, we tested if a non-invasive auricular electrical transcutaneous vagus nerve stimulation (tVNS) affects inflammation in models of POI...
3 CitationsSource