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Mai Kubodera
Helicobacter pyloriOral administrationMetronidazoleStomachAntibiotics
2Publications
1H-index
7Citations
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Publications 2
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#1Mai KuboderaH-Index: 1
#2Tadakazu Tokumura (Tokushima Bunri University)H-Index: 1
Last. Yoshiharu MachidaH-Index: 5
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In the eradication therapy of Helicobacter pylori, the changes of the amounts and concentrations of antibiotics in the stomach after oral administration were unclear. Amoxicillin (AMX) and metronidazole (MTZ), which are used for such therapy, were selected for this study. The levels of these drugs in homogenate of the stomach after their oral administration to rats were determined by HPLC. The doses of AMX and MTZ to the rats were 15 mg/kg and 5 mg/kg, respectively. The proportions of these drug...
#1Mai KuboderaH-Index: 1
#2Tadakazu Tokumura (International University of Health and Welfare)H-Index: 1
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
view all 3 authors...
Abstract In the eradication therapy of Helicobacter pylori changes of antibiotics as these concentrations or amount in the stomach after oral administration were not clear. A simple and accurate method for determining the concentration of metronidazole (MTZ) in homogenate of rat stomach was developed in order to obtain basic data to design a pharmaceutical preparation having targeting ability to the surface of gastric-mucosa. This method included a deproteinization process by methanol, separatio...
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