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Shinji Kume
Shiga University of Medical Science
EndocrinologyDiabetic nephropathyKidneyDiabetes mellitusMedicine
97Publications
30H-index
3,337Citations
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Publications 97
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Abstract To examine the cell-protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes, we analyzed the renal phenotype of tamoxifen (TM)-inducible podocyte-specific Atg5-deficient (iPodo-Atg5−/−) mice with experimental endothelial dysfunction. In both control and iPodo-Atg5−/− mice, high fat diet (HFD) feeding induced glomerular endothelial damage characterized by decreased urinary nitric oxide (NO) excretion, collapsed endothelial fenestrae, and reduced endot...
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#1Tomoyuki Tsukiyama (Kyoto University)H-Index: 2
#2Kenichi Kobayashi (Shiga University of Medical Science)H-Index: 3
Last. Masatsugu Ema (Kyoto University)H-Index: 36
view all 21 authors...
Autosomal dominant polycystic kidney disease (ADPKD) caused by PKD1 mutations is one of the most common hereditary disorders. However, the key pathological processes underlying cyst development and exacerbation in pre-symptomatic stages remain unknown, because rodent models do not recapitulate critical disease phenotypes, including disease onset in heterozygotes. Here, using CRISPR/Cas9, we generate ADPKD models with PKD1 mutations in cynomolgus monkeys. As in humans and mice, near-complete PKD1...
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#1Shoji Notomi (Kyushu University)H-Index: 4
#2Kenji Ishihara (Harvard University)H-Index: 1
Last. Demetrios G. Vavvas (Harvard University)H-Index: 33
view all 23 authors...
The early stages of age-related macular degeneration (AMD) are characterized by the accumulation of basal laminar deposits (BLamDs). The mechanism for BLamDs accumulating between the retinal pigment epithelium (RPE) and its basal lamina remains elusive. Here we examined the role in AMD of lysosome-associated membrane protein-2 (LAMP2), a glycoprotein that plays a critical role in lysosomal biogenesis and maturation of autophagosomes/phagosomes. LAMP2 was preferentially expressed by RPE cells, an...
2 CitationsSource
#1Shinji Kume (Shiga University of Medical Science)H-Index: 30
Diabetic nephropathy, which is characterized by increased albuminuria, has been the most common cause of end-stage kidney disease for many years in Japan and many other countries. Although the renal prognosis of the disease has been improving in recent years because of the clinical implementation of strict glucose, blood pressure, and lipid controls, some diabetes patients continue to exhibit treatment-resistant macroalbuminuria leading to end-stage kidney disease. Furthermore, renal function de...
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#1Shinji Kume (Shiga University of Medical Science)H-Index: 30
#2Shin-ichi Araki (Shiga University of Medical Science)H-Index: 39
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 9 authors...
6 CitationsSource
#1Issei Tomita (Shiga University of Medical Science)
#2Shinji Kume (Shiga University of Medical Science)H-Index: 30
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 11 authors...
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#1Sho Sugahara (Shiga University of Medical Science)
#2Shinji Kume (Shiga University of Medical Science)H-Index: 30
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 11 authors...
Background Energy metabolism in proximal tubular epithelial cells (PTECs) is unique, because ATP production largely depends on lipolysis in both the fed and fasting states. Furthermore, disruption of renal lipolysis is involved in the pathogenesis of diabetic tubulopathy. Emerging evidence suggests that protein O-GlcNAcylation, an intracellular nutrient-sensing system, may regulate a number of metabolic pathways according to changes in nutritional status. Although O-GlcNAcylation in PTECs has be...
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#1Shinji Kume (Shiga University of Medical Science)H-Index: 30
#2Issei Tomita (Shiga University of Medical Science)
Last. Hiroshi Maegawa (Shiga University of Medical Science)H-Index: 48
view all 11 authors...
Source
#1Hiroshi Nobuta (Shiga University of Medical Science)
#2Miwako Katagi (Shiga University of Medical Science)H-Index: 9
Last. Takahiko Nakagawa (Nara Medical University)H-Index: 6
view all 8 authors...
Diabetes mellitus causes systemic disorders. We previously demonstrated that diabetic condition forced bone marrow–derived cells (BMDCs) to express TNF-α, leading to the development of diabetic neu...
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#1Shohei Yoshida (Shiga University of Medical Science)H-Index: 1
#2Kosuke Yamahara (Shiga University of Medical Science)H-Index: 6
Last. Shin-ichi Araki (Shiga University of Medical Science)H-Index: 39
view all 12 authors...
6 CitationsSource
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