Bruce D. Levy
Brigham and Women's Hospital
What is this?
Publications 298
#1Michael C. Peters (UCSF: University of California, San Francisco)H-Index: 15
#2David T. Mauger (Penn State Milton S. Hershey Medical Center)H-Index: 57
Last. Nizar N. Jarjour (UW: University of Wisconsin-Madison)H-Index: 55
view all 17 authors...
Background: Cross-sectional studies suggest an exacerbation-prone asthma (EPA) phenotype and the utility of blood eosinophils and plasma interleukin 6 (IL-6) as predictive biomarkers. Objective: To...
#1Victor E. Ortega (Wake Forest University)H-Index: 12
#2D. Kim (USF: University of South Florida)
Last. Igor Barjaktarevic (UCLA: University of California, Los Angeles)H-Index: 9
view all 38 authors...
#2Fernando J. Martinez (Cornell University)H-Index: 114
Last. JadwigaAWedzicha (NIH: National Institutes of Health)H-Index: 89
view all 10 authors...
#1Michael C. Peters (UCSF: University of California, San Francisco)H-Index: 15
#2Satria SajuthiH-Index: 4
Last. Mats W. Johansson (University of Wisconsin Colleges)H-Index: 22
view all 22 authors...
BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by SARS-coronavirus 2 (SARS-CoV-2). Angiotensin converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) mediate viral infection of host cells. We reasoned that differences in ACE2 or TMPRSS2 gene expression in sputum cells among asthma patients may identify subgroups at risk for COVID19 morbidity. METHODS: We analyzed gene expression for ACE2 and TMPRSS2, and for intercellular adhesion molecule 1 (ICAM-1)(rhinovirus recep...
8 CitationsSource
#1Matthew W. Semler (VUMC: Vanderbilt University Medical Center)H-Index: 19
#2Gordon R. Bernard (VUMC: Vanderbilt University Medical Center)H-Index: 93
Last. Michelle Ng GongH-Index: 34
view all 26 authors...
Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the National Heart, Lung, and Blood Institute. Decades of clinical research in acute respiratory distress syndrome, acute respiratory failure, pneumonia, and sepsis have yielded improvements in supportive care, which have translated into improved patient outcomes. Novel therapeutics have largely failed to translate from promising pre-clinical findi...
#1Miguel Reyes (MIT: Massachusetts Institute of Technology)
#1Miguel Reyes (MIT: Massachusetts Institute of Technology)H-Index: 4
Last. Marcia B. Goldberg (Broad Institute)H-Index: 38
view all 11 authors...
Dysregulation of the immune response to bacterial infection can lead to sepsis, a condition with high mortality. Multiple whole-blood gene-expression studies have defined sepsis-associated molecular signatures, but have not resolved changes in transcriptional states of specific cell types. Here, we used single-cell RNA-sequencing to profile the blood of people with sepsis (n = 29) across three clinical cohorts with corresponding controls (n = 36). We profiled total peripheral blood mononuclear c...
3 CitationsSource
#1Sébastien TalbotH-Index: 16
#2Benjamin DoyleH-Index: 1
Last. Bruce P. BeanH-Index: 67
view all 12 authors...
#1Annette T. Hastie (Wake Forest University)H-Index: 28
#2Dave T. Mauger (PSU: Pennsylvania State University)H-Index: 2
Last. Wendy C. Moore (Wake Forest University)H-Index: 39
view all 16 authors...
: Combined elevated sputum eosinophils+neutrophils in asthma associated with lowest lung function, greater healthcare utilization, and longitudinally, further spirometric loss, implicating cell-cell interactions or overlapping inflammatory pathways while increased eosinophils or neutrophils alone show less effect.
#1Samuel Y. Ash (Brigham and Women's Hospital)H-Index: 9
#2Gonzalo Vegas Sanchez-Ferrero (Brigham and Women's Hospital)H-Index: 4
view all 61 authors...
Abstract Background Relative enlargement of the pulmonary artery (PA) on chest computed tomography (CT) is associated with respiratory exacerbations in patients with chronic obstructive pulmonary disease or cystic fibrosis. We sought to determine if similar findings were present in patients with asthma and if they were explained by differences in ventricular size. Methods We measured the PA and aorta diameters in 233 individuals from the Severe Asthma Research Program III cohort. We also estimat...
1 CitationsSource