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Kathryn E. Kemper
University of Queensland
Genome-wide association studyPopulationGeneticsQuantitative trait locusBiology
70Publications
22H-index
1,541Citations
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Publications 80
Newest
#1Baptiste Couvy-Duchesne (UQ: University of Queensland)H-Index: 11
#1Baptiste Couvy-Duchesne (University of Paris)
Last. Jian Yang (WMU: Wenzhou Medical College)
view all 8 authors...
We evaluated the statistical power, family wise error rate (FWER) and precision of several competing methods that perform mass-univariate vertex-wise analyses of grey-matter (thickness and surface area). In particular, we compared several generalised linear models (GLMs, current state of the art) to linear mixed models (LMMs) that have proven superior in genomics. We used phenotypes simulated from real vertex-wise data and a large sample size (N=8,662) which may soon become the norm in neuroimag...
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#1Joana A Revez (UQ: University of Queensland)H-Index: 1
#1Joana A. Revez (UQ: University of Queensland)H-Index: 5
Last. Kathryn E. Kemper (UQ: University of Queensland)H-Index: 22
view all 21 authors...
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that ...
2 CitationsSource
#1Maria Niarchou (Medical Research Council)H-Index: 8
#2Enda M. Byrne (UQ: University of Queensland)H-Index: 33
Last. Naomi R. Wray (UQ: University of Queensland)H-Index: 79
view all 9 authors...
Motivated by observational studies that report associations between schizophrenia and traits, such as poor diet, increased body mass index and metabolic disease, we investigated the genetic contribution to dietary intake in a sample of 335,576 individuals from the UK Biobank study. A principal component analysis applied to diet question item responses generated two components: Diet Component 1 (DC1) represented a meat-related diet and Diet Component 2 (DC2) a fish and plant-related diet. Genome-...
2 CitationsSource
#1Joana A Revez (UQ: University of Queensland)H-Index: 1
#1Joana A. Revez (UQ: University of Queensland)H-Index: 5
Last. John J. McGrath (UQ: University of Queensland)H-Index: 103
view all 21 authors...
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identified 143 independent loci in 112 1-Mb regions providing new insights into the physiology of vitamin D and implicating genes involved in (a) lipid and lipoprotein metabolism, (b) dermal tissue properties, and (c) the sulphonation and glucuronidation of 25OHD. Mendelian randomization models found no rob...
Source
#1Luke R. Lloyd-Jones (UQ: University of Queensland)H-Index: 10
#2Jian Zeng (UQ: University of Queensland)H-Index: 11
Last. Peter M. Visscher (UQ: University of Queensland)H-Index: 109
view all 15 authors...
Accurate prediction of an individual’s phenotype from their DNA sequence is one of the great promises of genomics and precision medicine. We extend a powerful individual-level data Bayesian multiple regression model (BayesR) to one that utilises summary statistics from genome-wide association studies (GWAS), SBayesR. In simulation and cross-validation using 12 real traits and 1.1 million variants on 350,000 individuals from the UK Biobank, SBayesR improves prediction accuracy relative to commonl...
13 CitationsSource
#1Abdel Abdellaoui (UvA: University of Amsterdam)H-Index: 28
#1Abdel Abdellaoui (UvA: University of Amsterdam)H-Index: 4
Last. Peter M. Visscher (UQ: University of Queensland)H-Index: 109
view all 13 authors...
Human DNA polymorphisms vary across geographic regions, with the most commonly observed variation reflecting distant ancestry differences. Here we investigate the geographic clustering of common genetic variants that influence complex traits in a sample of ~450,000 individuals from Great Britain. Of 33 traits analysed, 21 showed significant geographic clustering at the genetic level after controlling for ancestry, probably reflecting migration driven by socioeconomic status (SES). Alleles associ...
11 CitationsSource
#1Jian Zeng (UQ: University of Queensland)H-Index: 11
#2Angli Xue (UQ: University of Queensland)H-Index: 6
Last. Jian Yang (WMU: Wenzhou Medical College)H-Index: 113
view all 13 authors...
Understanding how natural selection has shaped the genetic architecture of complex traits and diseases is of importance in medical and evolutionary genetics. Bayesian methods have been developed using individual-level data to estimate multiple features of genetic architecture, including signatures of natural selection. Here, we present an enhanced method (SBayesS) that only requires GWAS summary statistics and incorporates functional genomic annotations. We analysed GWAS data with large sample s...
2 CitationsSource
#1Huanwei Wang (UQ: University of Queensland)H-Index: 2
#2Fengchun Zhang (UQ: University of Queensland)H-Index: 13
Last. Jian Yang (WMU: Wenzhou Medical College)H-Index: 113
view all 13 authors...
Genotype-by-environment interaction (GEI) is a fundamental component in understanding complex trait variation. However, it remains challenging to identify genetic variants with GEI effects in humans largely because of the small effect sizes and the difficulty of monitoring environmental fluctuations. Here, we demonstrate that GEI can be inferred from genetic variants associated with phenotypic variability in a large sample without the need of measuring environmental factors. We performed a genom...
8 CitationsSource
#1Baptiste Couvy-Duchesne (UQ: University of Queensland)H-Index: 11
#2Lachlan T. Strike (UQ: University of Queensland)H-Index: 11
Last. Peter M. Visscher (UQ: University of Queensland)H-Index: 109
view all 12 authors...
The recent availability of large-scale neuroimaging cohorts (here the UK Biobank [UKB] and the Human Connectome Project [HCP]) facilitates deeper characterisation of the relationship between phenotypic and brain architecture variation in humans. We tested the association between 654,386 vertex-wise measures of cortical and subcortical morphology (from T1w and T2w MRI images) and behavioural, cognitive, psychiatric and lifestyle data. We found a significant association of grey-matter structure wi...
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#1Yeda Wu (UQ: University of Queensland)H-Index: 2
#2Enda M. Byrne (UQ: University of Queensland)H-Index: 33
Last. Naomi R. Wray (UQ: University of Queensland)H-Index: 79
view all 9 authors...
Genome-wide association studies (GWASs) of medication use may contribute to understanding of disease etiology, could generate new leads relevant for drug discovery and can be used to quantify future risk of medication taking. Here, we conduct GWASs of self-reported medication use from 23 medication categories in approximately 320,000 individuals from the UK Biobank. A total of 505 independent genetic loci that meet stringent criteria (P < 10−8/23) for statistical significance are identified. We ...
3 CitationsSource
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