Aurora M. Nedelcu
University of New Brunswick
44Publications
21H-index
3,449Citations
Publications 44
Newest
Published on Jan 1, 2019in Development Genes and Evolution 2.13
Aurora M. Nedelcu21
Estimated H-index: 21
(University of New Brunswick)
The evolution of multicellularity is a premier example of phenotypic convergence: simple multicellularity evolved independently many times, and complex multicellular phenotypes are found in several distant groups. Furthermore, both animal and plant lineages have independently reached extreme levels of morphological, functional, and developmental complexity. This study explores the genetic basis for the parallel evolution of complex multicellularity and development in the animal and green plant (...
Source Cite
Published on Mar 12, 2018in Frontiers in Oncology
Alexander N. May1
Estimated H-index: 1
(University of New Brunswick),
Bryan D. Crawford12
Estimated H-index: 12
(University of New Brunswick),
Aurora M. Nedelcu21
Estimated H-index: 21
(University of New Brunswick)
The isolation of clusters of circulating tumor cells (CTCs) from cancer patients has recently challenged the accepted view that the initiation of secondary tumors during metastasis involves the dissemination of individual cancer cells. As such clusters appear to be more aggressive than single tumor cells, CTC clusters are now considered a main player in the metastatic process, and many studies are exploring their diagnostic, prognostic and clinical significance. However, several technical challe...
2 Citations Source Cite
Published on Feb 1, 2017in Plant Physiology 5.95
Francisco Figueroa-Martinez4
Estimated H-index: 4
(University of New Brunswick),
Aurora M. Nedelcu21
Estimated H-index: 21
(University of New Brunswick)
+ 1 AuthorsAdrian Reyes-Prieto11
Estimated H-index: 11
(University of New Brunswick)
The loss of photosynthesis is frequently associated with parasitic or pathogenic lifestyles, but it also can occur in free-living, plastid-bearing lineages. A common consequence of becoming nonphotosynthetic is the reduction in size and gene content of the plastid genome. In exceptional circumstances, it can even result in the complete loss of the plastid DNA (ptDNA) and its associated gene expression system, as reported recently in several lineages, including the nonphotosynthetic green algal g...
13 Citations Source Cite
Published on Jan 2, 2017in Communicative & Integrative Biology
Francisco Figueroa-Martinez4
Estimated H-index: 4
(Canadian Institute for Advanced Research),
Aurora M. Nedelcu21
Estimated H-index: 21
(Canadian Institute for Advanced Research)
+ 1 AuthorsDavid Roy Smith26
Estimated H-index: 26
(Canadian Institute for Advanced Research)
ABSTRACTThe thing about plastid genomes in nonphotosynthetic plants and algae is that they are usually very small and highly compact. This is not surprising: a heterotrophic existence means that genes for photosynthesis can be easily discarded. But the loss of photosynthesis cannot explain why the plastomes of heterotrophs are so often depauperate in noncoding DNA. If plastid genomes from photosynthetic taxa can span the gamut of compactness, why can't those of nonphotosynthetic species? Well, r...
5 Citations Source Cite
Published on Aug 1, 2016in Current Opinion in Genetics & Development 5.00
Bradley J. S. C. Olson18
Estimated H-index: 18
(Kansas State University),
Aurora M. Nedelcu21
Estimated H-index: 21
(University of New Brunswick)
Despite its major impact on the evolution of Life on Earth, the transition to multicellularity remains poorly understood, especially in terms of its genetic basis. The volvocine algae are a group of closely related species that range in morphology from unicellular individuals ( Chlamydomonas ) to undifferentiated multicellular forms ( Gonium ) and complex organisms with distinct developmental programs and one ( Pleodorina ) or two ( Volvox ) specialized cell types. Modern genetic approaches, com...
5 Citations Source Cite
Published on Jan 1, 2015
Susan Sharpe1
Estimated H-index: 1
,
Ricard V. Solé58
Estimated H-index: 58
+ 3 AuthorsDale Kaiser1
Estimated H-index: 1
20 Citations Source Cite
Published on May 1, 2015in New Phytologist 7.43
Francisco Figueroa-Martinez4
Estimated H-index: 4
(University of New Brunswick),
Aurora M. Nedelcu21
Estimated H-index: 21
(University of New Brunswick)
+ 1 AuthorsAdrian Reyes-Prieto11
Estimated H-index: 11
(University of New Brunswick)
Summary The endosymbiotic origin of plastids was a launching point for eukaryotic evolution. The autotrophicabilitiesbestowedbyplastidsareresponsibleformuchoftheeukaryoticdiversitywe observe today. But despite its many advantages, photosynthesis has been lost numerous times and in disparate lineages throughout eukaryote evolution. For example, among green algae, several groups have lost photosynthesis independently and in response to different selective pressures; these include the parasitic/pat...
27 Citations Source Cite
Published on Jun 24, 2014in PLOS Biology 9.16
Patrick J. Keeling69
Estimated H-index: 69
(University of British Columbia),
Fabien Burki25
Estimated H-index: 25
(University of British Columbia)
+ 78 AuthorsCallum J. Bell11
Estimated H-index: 11
(National Center for Genome Resources)
Current sampling of genomic sequence data from eukaryotes is relatively poor, biased, and inadequate to address important questions about their biology, evolution, and ecology; this Community Page describes a resource of 700 transcriptomes from marine microbial eukaryotes to help understand their role in the world's oceans.
321 Citations Source Cite
Published on Jan 1, 2013in Evolutionary Applications 4.69
Kathleen Sprouffske8
Estimated H-index: 8
(University of Pennsylvania),
C. Athena Aktipis17
Estimated H-index: 17
(Arizona State University)
+ 3 AuthorsCarlo C. Maley37
Estimated H-index: 37
(University of California, San Francisco)
Contrary to conventional views that assume all cells in a neoplasm can propagate the tumor, the cancer stem cell hypothesis posits that only a fraction of the cells (the cancer stem cells) can act as tumor-propagating cells, while most of the tumor is composed of cells with limited replication potential. Here, we offer an evolutionary approach to this controversy. We used several evolutionary, computational models to investigate cancer cell dynamics and conditions consistent with the stem cell h...
19 Citations Source Cite
Published on Jan 1, 2012in Advances in Experimental Medicine and Biology 1.76
Aurora M. Nedelcu21
Estimated H-index: 21
(University of New Brunswick)
The notion of ’ self’ is intrinsically linked to the concepts of identity and individuality. During evolutionary transitions in individuality—such as, for instance, during the origin of the first cell, the origin of the eukaryotic cell and the origin of multicellular individuals—new kinds of individuals emerged from the interaction of previously independent entities. The question discussed here is: How can new types of individuals with qualities that cannot be reduced to the properties of their ...
3 Citations Source Cite
12345