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Aurora M. Nedelcu
University of New Brunswick
43Publications
22H-index
3,371Citations
Publications 43
Newest
Alexander N. May1
Estimated H-index: 1
(University of New Brunswick),
Bryan D. Crawford8
Estimated H-index: 8
(University of New Brunswick),
Aurora M. Nedelcu22
Estimated H-index: 22
(University of New Brunswick)
The isolation of clusters of circulating tumor cells (CTCs) from cancer patients has recently challenged the accepted view that the initiation of secondary tumors during metastasis involves the dissemination of individual cancer cells. As such clusters appear to be more aggressive than single tumor cells, CTC clusters are now considered a main player in the metastatic process, and many studies are exploring their diagnostic, prognostic and clinical significance. However, several technical challe...
2 Citations Source Cite
2017
Aurora M. Nedelcu22
Estimated H-index: 22
(University of New Brunswick)
Most current therapies are directed toward “fighting” cancer by playing against its strengths. Here, I suggest that alternative strategies that would be directed against cancer evolutionary weaknesses by taking advantage of potential vulnerabilities inherited from our unicellular ancestors should also be developed. This requires a shift in focus from understanding the many ways through which cancer succeeds in exposing and exploiting its evolutionary limitations. Such strategies can involve driv...
Source Cite
2017 in Plant PhysiologyIF: 5.95
Francisco Figueroa-Martinez4
Estimated H-index: 4
(University of New Brunswick),
Aurora M. Nedelcu22
Estimated H-index: 22
(University of New Brunswick)
+ 1 AuthorsAdrian Reyes-Prieto11
Estimated H-index: 11
(University of New Brunswick)
The loss of photosynthesis is frequently associated with parasitic or pathogenic lifestyles, but it also can occur in free-living, plastid-bearing lineages. A common consequence of becoming nonphotosynthetic is the reduction in size and gene content of the plastid genome. In exceptional circumstances, it can even result in the complete loss of the plastid DNA (ptDNA) and its associated gene expression system, as reported recently in several lineages, including the nonphotosynthetic green algal g...
12 Citations Download PDF Cite
Francisco Figueroa-Martinez4
Estimated H-index: 4
(Canadian Institute for Advanced Research),
Aurora M. Nedelcu22
Estimated H-index: 22
(Canadian Institute for Advanced Research)
+ 1 AuthorsDavid Roy Smith26
Estimated H-index: 26
(Canadian Institute for Advanced Research)
ABSTRACTThe thing about plastid genomes in nonphotosynthetic plants and algae is that they are usually very small and highly compact. This is not surprising: a heterotrophic existence means that genes for photosynthesis can be easily discarded. But the loss of photosynthesis cannot explain why the plastomes of heterotrophs are so often depauperate in noncoding DNA. If plastid genomes from photosynthetic taxa can span the gamut of compactness, why can't those of nonphotosynthetic species? Well, r...
5 Citations Source Cite
2016
Aurora M. Nedelcu22
Estimated H-index: 22
(University of New Brunswick),
Aleah F. Caulin4
Estimated H-index: 4
(University of Pennsylvania)
Cancer is generally seen as a by-product of the transition to multicellularity. In this view, cancer is a reflection of the breakdown of somatic cell cooperation that ultimately results in a reversion to a unicellular-like state. Under these circumstances, the evolutionary stability of multicellular individuals is thought to require a combination of mechanisms that prevent the occurrence of selfish cell mutants (i.e., mechanisms that decrease genetic variation within the group) as well as strate...
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Bradley J. S. C. Olson9
Estimated H-index: 9
(Kansas State University),
Aurora M. Nedelcu22
Estimated H-index: 22
(University of New Brunswick)
Despite its major impact on the evolution of Life on Earth, the transition to multicellularity remains poorly understood, especially in terms of its genetic basis. The volvocine algae are a group of closely related species that range in morphology from unicellular individuals ( Chlamydomonas ) to undifferentiated multicellular forms ( Gonium ) and complex organisms with distinct developmental programs and one ( Pleodorina ) or two ( Volvox ) specialized cell types. Modern genetic approaches, com...
4 Citations Source Cite
2015
Matthew D. Herron12
Estimated H-index: 12
(University of Montana),
Aurora M. Nedelcu22
Estimated H-index: 22
(University of New Brunswick)
The evolution of multicellularity provided new ways for biological systems to increase in complexity . However, although high levels of complexity have indeed been attained in several multicellular lineages, natural selection does not necessarily favor complex biological systems. Why and how, then, has complexity increased in some lineages? We argue that the volvocine green algae (Volvox and its relatives) are a uniquely valuable model system for understanding the evolution of multicellular comp...
1 Citations Source Cite
2015
John O. Kessler22
Estimated H-index: 22
(University of Arizona),
Aurora M. Nedelcu22
Estimated H-index: 22
(University of New Brunswick)
+ 1 AuthorsDeborah E. Shelton6
Estimated H-index: 6
(University of Arizona)
The volvocine green algae have been extensively used to address various questions related to the evolution of multicellularity and cell differentiation, in terms of the genetics, developmental constraints, and underlying selective forces specific to this group. More recently, physical characteristics of the environment and of the emerging multi-celled entities have also been considered as potential contributors to the evolution of multicellularity in this lineage. However, the role of light in t...
3 Citations Source Cite
2015 in New PhytologistIF: 7.43
Francisco Figueroa-Martinez4
Estimated H-index: 4
(University of New Brunswick),
Aurora M. Nedelcu22
Estimated H-index: 22
(University of New Brunswick)
+ 1 AuthorsAdrian Reyes-Prieto11
Estimated H-index: 11
(University of New Brunswick)
Summary The endosymbiotic origin of plastids was a launching point for eukaryotic evolution. The autotrophicabilitiesbestowedbyplastidsareresponsibleformuchoftheeukaryoticdiversitywe observe today. But despite its many advantages, photosynthesis has been lost numerous times and in disparate lineages throughout eukaryote evolution. For example, among green algae, several groups have lost photosynthesis independently and in response to different selective pressures; these include the parasitic/pat...
27 Citations Download PDF Cite
2015
Susan Sharpe1
Estimated H-index: 1
,
Ricard V. Solé57
Estimated H-index: 57
+ 3 AuthorsDale Kaiser1
Estimated H-index: 1
20 Citations Source Cite
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