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Robin J Borchert
University of Cambridge
12Publications
4H-index
163Citations
Publications 12
Newest
#1Luca PassamontiH-Index: 28
#2Kamen A. Tsvetanov (University of Cambridge)H-Index: 10
Last.James B. Rowe (University of Cambridge)H-Index: 57
view all 10 authors...
Neuroinflammation is a key part of the etio-pathogenesis of Alzheimer9s disease (AD). We tested the relationship between neuroinflammation and the disruption of functional connectivity in large-scale networks, and their joint influence on cognitive impairment. We combined [11C]PK11195 positron emission tomography (PET) and resting-state functional magnetic resonance imaging (rs-fMRI) in 28 patients (12 females/16 males) with clinical diagnosis of probable AD or mild cognitive impairment with pos...
1 CitationsSource
#1Timothy Rittman (University of Cambridge)H-Index: 19
#2Robin J Borchert (University of Cambridge)H-Index: 4
Last.Miren ZulaicaH-Index: 2
view all 125 authors...
The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despit...
3 CitationsSource
#1Luca Passamonti (University of Cambridge)H-Index: 28
#2Kamen A. Tsvetanov (University of Cambridge)H-Index: 10
Last.James B. Rowe (University of Cambridge)H-Index: 57
view all 10 authors...
Neuroinflammation is a key part of the etio-pathogenesis of Alzheimer9s disease. We test the relationship between neuroinflammation and the disruption of functional connectivity in large-scale networks, and their joint influence on cognitive impairment. We combined [11C]PK11195 positron emission tomography (PET) and resting-state functional magnetic resonance imaging (rs-fMRI) in 28 humans (13 females/15 males) with clinical diagnosis of probable Alzheimer[prime]s disease or mild cognitive impai...
Source
#1Robin J Borchert (University of Cambridge)H-Index: 4
#2Timothy Rittman (University of Cambridge)H-Index: 19
Last.James B. Rowe (University of Cambridge)H-Index: 57
view all 12 authors...
Parkinson’s disease has multiple detrimental effects on motor and cognitive systems in the brain. In contrast to motor deficits, cognitive impairments in Parkinson’s disease are usually not ameliorated, and can even be worsened, by dopaminergic treatments. Recent evidence has shown potential benefits from restoring other neurotransmitter deficits, including noradrenergic and serotonergic transmission. Here, we study global and regional brain network organization using task-free imaging (also kno...
Source
#1Luca PassamontiH-Index: 28
Last.James B. RoweH-Index: 57
view all 16 authors...
Objective We tested whether in vivo neuroinflammation relates to the distinctive distributions of pathology in Alzheimer disease (AD) and progressive supranuclear palsy (PSP). Methods Sixteen patients with symptomatic AD (including amnestic mild cognitive impairment with amyloid-positive PET scan), 16 patients with PSP–Richardson syndrome, and 13 age-, sex-, and education-matched healthy controls were included in this case-control study. Participants underwent [ 11 C]PK11195 PET scanning, which ...
15 CitationsSource
#1Thomas E. Cope (University of Cambridge)H-Index: 12
#2Timothy Rittman (University of Cambridge)H-Index: 19
Last.James B. Rowe (University of Cambridge)H-Index: 57
view all 11 authors...
NIHR, MRC, Wellcome, Patrick Berthoud Charitable Trust, Association of British Neurologists
45 CitationsSource
1 CitationsSource
#1Thomas E. CopeH-Index: 12
#2Robin J BorchertH-Index: 4
Last.James B. RoweH-Index: 57
view all 9 authors...
Source
#1Timothy RittmanH-Index: 19
#2Robin J BorchertH-Index: 4
Last.James B. RoweH-Index: 57
view all 16 authors...
Source
#1Luca Passamonti (University of Cambridge)H-Index: 28
#2Rodríguez Patricia Vázquez (University of Cambridge)H-Index: 1
Last.James B. Rowe (University of Cambridge)H-Index: 57
view all 18 authors...
This study was funded by the National Institute for Health Research (NIHR, RG64473) Cambridge Biomedical Research Centre and Biomedical Research Unit in Dementia, PSP Association, the Wellcome Trust (JBR 103838), the Medical Research Council of Cognition and Brain Sciences Unit, Cambridge (MC-A060-5PQ30), and partially by a Medical Research Council grant (MR/K02308X/1) held by J.T.O., J.B.R., and F.I.A. The Human Research Tissue Bank is supported by the NIHR Cambridge Biomedical Research Centre.
77 CitationsSource
12