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Robin Borchert
University of Cambridge
10Publications
4H-index
117Citations
Publications 10
Newest
Published on May 1, 2019in Neurobiology of Aging 4.40
Timothy Rittman18
Estimated H-index: 18
(University of Cambridge),
Robin Borchert4
Estimated H-index: 4
(University of Cambridge)
+ 122 AuthorsFabrizio Tagliavini60
Estimated H-index: 60
The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despit...
1 Citations Source Cite
Published on Jan 28, 2019in bioRxiv
Luca Passamonti26
Estimated H-index: 26
(University of Cambridge),
Kamen A. Tsvetanov9
Estimated H-index: 9
+ 7 AuthorsJames B. Rowe53
Estimated H-index: 53
Neuroinflammation is a key part of the etio-pathogenesis of Alzheimer9s disease. We test the relationship between neuroinflammation and the disruption of functional connectivity in large-scale networks, and their joint influence on cognitive impairment. We combined [11C]PK11195 positron emission tomography (PET) and resting-state functional magnetic resonance imaging (rs-fMRI) in 28 humans (13 females/15 males) with clinical diagnosis of probable Alzheimer[prime]s disease or mild cognitive impai...
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Published on May 29, 2018in Neurology 8.69
Luca Passamonti26
Estimated H-index: 26
,
Patricia Vázquez Rodríguez8
Estimated H-index: 8
+ 13 AuthorsAjenthan Surendranathan6
Estimated H-index: 6
Objective We tested whether in vivo neuroinflammation relates to the distinctive distributions of pathology in Alzheimer disease (AD) and progressive supranuclear palsy (PSP). Methods Sixteen patients with symptomatic AD (including amnestic mild cognitive impairment with amyloid-positive PET scan), 16 patients with PSP–Richardson syndrome, and 13 age-, sex-, and education-matched healthy controls were included in this case-control study. Participants underwent [ 11 C]PK11195 PET scanning, which ...
12 Citations Source Cite
Published on Feb 1, 2018in Brain 11.81
Thomas E. Cope12
Estimated H-index: 12
(University of Cambridge),
Timothy Rittman18
Estimated H-index: 18
(University of Cambridge)
+ 8 AuthorsJohn T. O'Brien97
Estimated H-index: 97
(University of Cambridge)
NIHR, MRC, Wellcome, Patrick Berthoud Charitable Trust, Association of British Neurologists
29 Citations Source Cite
Published on Jul 1, 2017in Alzheimers & Dementia 14.42
Patricia Vázquez Rodríguez8
Estimated H-index: 8
,
Luca Passamonti26
Estimated H-index: 26
+ 11 AuthorsLi Su14
Estimated H-index: 14
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Published on Jul 1, 2017in Alzheimers & Dementia 14.42
Thomas E. Cope12
Estimated H-index: 12
,
Robin Borchert4
Estimated H-index: 4
+ 6 AuthorsJames B. Rowe53
Estimated H-index: 53
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Published on Jan 24, 2017in Brain 11.81
Luca Passamonti26
Estimated H-index: 26
(University of Cambridge),
Rodríguez Patricia Vázquez1
Estimated H-index: 1
(University of Cambridge)
+ 15 AuthorsPeter Jones33
Estimated H-index: 33
(University of Cambridge)
This study was funded by the National Institute for Health Research (NIHR, RG64473) Cambridge Biomedical Research Centre and Biomedical Research Unit in Dementia, PSP Association, the Wellcome Trust (JBR 103838), the Medical Research Council of Cognition and Brain Sciences Unit, Cambridge (MC-A060-5PQ30), and partially by a Medical Research Council grant (MR/K02308X/1) held by J.T.O., J.B.R., and F.I.A. The Human Research Tissue Bank is supported by the NIHR Cambridge Biomedical Research Centre.
64 Citations Source Cite
Published on Jul 1, 2016in Neuropsychopharmacology 7.16
Robin Borchert4
Estimated H-index: 4
,
Timothy Rittman18
Estimated H-index: 18
+ 10 AuthorsCharlotte L. Rae11
Estimated H-index: 11
Cognitive impairment is common in Parkinson's disease (PD), but often not improved by dopaminergic treatment. New treatment strategies targeting other neurotransmitter deficits are therefore of growing interest. Imaging the brain at rest ('task-free') provides the opportunity to examine the impact of a candidate drug on many of the brain networks that underpin cognition, while minimizing task related performance confounds. We test this approach using atomoxetine, a selective noradrenaline reupta...
16 Citations Source Cite
12