Robert A. Olek
Gdańsk Medical University
EndocrinologyOxidative stressBiochemistryDiabetes mellitusBiology
What is this?
Publications 36
l-carnitine supplementation has been used for cardiovascular health protection for a long time. Recently, trimethylamine-N-oxide (TMAO), which is an end product of l-carnitine metabolism via the activity of microbiota, has been identified as a cardiovascular disease (CVD) biomarker. The aim of this study was to assess the effect of 6 months of l-carnitine supplementation in a group of aged women engaged in a regular physical training. Platelet mitochondrial DNA methylation, an emerging and innov...
1 CitationsSource
#1Sylwester KujachH-Index: 7
#2Robert A. OlekH-Index: 12
Last. Hideaki SoyaH-Index: 27
view all 8 authors...
There is increasing attention to sprint interval exercise (SIE) training as a time-efficient exercise regime. Recent studies, including our own (Kujach et al., 2018), have shown that acute high-intensity intermittent exercise can improve cognitive function; however, the neurobiological mechanisms underlying the effect still remain unknown. We thus examined the effects of acute SIE on cognitive function by monitoring the peripheral levels of growth and neurotrophic factors as well as blood lactat...
#1Stanislaw Zajaczkowski (Gdańsk Medical University)H-Index: 1
#2Piotr Badtke (Gdańsk Medical University)H-Index: 1
Last. Tomasz H. Wierzba (Gdańsk Medical University)H-Index: 7
view all 6 authors...
L-carnitine which shuttles fatty acid into the mitochondria is known diet supplement used by athletes to improve physical performance. It is also used in supplementary treatment in cardiac insufficiency. Since effect of L-carnitine on cardiovascular regulation is unclear we investigated whether its prolonged supplementation would affect autonomic nervous system (ANS) control upon the heart in healthy elderly volunteers.Thirteen apparently healthy women aged 64 to 71 were supplemented in the doub...
#1Tomasz H. Wierzba (Gdańsk Medical University)H-Index: 7
#2Stanislaw Zajaczkowski (Gdańsk Medical University)H-Index: 1
Last. Artur Polinski (GUT: Gdańsk University of Technology)H-Index: 5
view all 5 authors...
Regulatory synchronization between the heart and the arterial walls is essential for optimal blood delivery to tissues. We investigated functional coherence between heart rhythm and aortic wall compliance in 30 volunteers aged 65 – 74. ECG, carotid and iliac pulse-wave were recorded and digitized at 2 kHz. Carotid-femoral pulse-wave transit time (cfTT) which reflects aortic compliance was assessed using the intersecting tangent algorithm at time-point of the maximal upstroke of the second deriva...
Increased plasma trimethylamine N-oxide (TMAO) levels have been associated with cardiovascular diseases (CVD). L-carnitine induces TMAO elevation in human blood, and thus, it has been suggested as developing atherosclerosis. The aim of this study was to determine the relation between selected markers of oxidative stress and plasma TMAO concentration induced by L-carnitine supplementation for 24 weeks in healthy aged women. Twenty aged women were supplemented during 24 weeks with either 1500 mg L...
2 CitationsSource
#1Joanna J. SamulakH-Index: 1
Last. Robert A. OlekH-Index: 12
view all 4 authors...
L-carnitine supplementation elevates plasma trimethylamine-N-oxide (TMAO), which may participate in atherosclerosis development by affecting cholesterol metabolism. The aim of the current study was to determine the effect of increased plasma TMAO on biochemical markers in the blood following cessation of L-carnitine supplementation. The follow-up measurements were performed on subjects who completed 24 weeks of L-carnitine or placebo supplementation protocol. Blood samples were taken after finis...
1 CitationsSource
3 CitationsSource
#2Sylwester KujachH-Index: 7
Last. Robert A. OlekH-Index: 12
view all 7 authors...
Objective The aim of our study was to investigate the adaptive effect of six sessions of high intensity interval training (HIIT) on changes in the amount and activity of mitochondrial enzymes. Methods Twenty seven students (age 21.2±0.9) were assigned to HIIT (n=10) and control (CON, n=17) group and performed six training sessions for 14 days: 6 × 90 s intervals at 80% maximal aerobic power (MAP) output separated by 180 s rest. Pre and post interventions anthropometric measurements, maximal acti...
#1Robert A. OlekH-Index: 12
#2Sylwester KujachH-Index: 7
Last. Radosław LaskowskiH-Index: 9
view all 6 authors...
Purpose: The aim of this study was to compare the effect of applying two different rest recovery times in a 10-s sprint interval training session on aerobic and anaerobic capacities as well as skeletal muscle enzymes activities. Methods: Fourteen physically active but not highly trained male subjects (mean maximal oxygen uptake 50.5 ± 1.0 mlO2•kg-1•min-1) participated in the study. The training protocol involved a series of 10-s sprints separated by either 1-min (SIT10:1) or 4-min (SIT10:4) of r...
2 CitationsSource
#2Dace HartmaneH-Index: 1
Last. Robert A. OlekH-Index: 12
view all 6 authors...
Skeletal muscle wasting, associated with aging, may be regulated by the inflammatory cytokines as well as by insulin-like growth factor 1 (IGF-1). l-carnitine possesses anti-inflammatory properties and increases plasma IGF-1 concentration, leading to the regulation of the genes responsible for protein catabolism and anabolism. The purpose of the present study was to evaluate the effect of a 24-week l-carnitine supplementation on serum inflammatory markers, IGF-1, body composition and skeletal mu...
4 CitationsSource