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Julien Wicinski
Aix-Marseille University
23Publications
12H-index
1,806Citations
Publications 23
Newest
#1Abir Arfaoui (AMU: Aix-Marseille University)H-Index: 1
#2Claire Rioualen (AMU: Aix-Marseille University)H-Index: 4
Last.Candi Léonard‐Stumpf (AMU: Aix-Marseille University)
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Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic target to improve cancer treatment. Here, we carried out a genome-wide RNA interference screen to identify genes that regulate breast CSCs-fate (bCSC). Using an interactome/regulome analysis, we integrated screen results in a functional mapping of the CSC-relate...
#1Leonor Lopez Almeida (AMU: Aix-Marseille University)
#2Michael Sebbagh (AMU: Aix-Marseille University)H-Index: 14
Last.Christophe Ginestier (AMU: Aix-Marseille University)H-Index: 43
view all 12 authors...
Summary Tumor initiation, progression, and therapeutic resistance have been proposed to originate from a subset of tumor cells, cancer stem cells (CSCs). However, the current understanding of the mechanisms involved in their self-renewal and tumor initiation capacity remains limited. Here, we report that expression of LANO/LRRC1 , the vertebrate paralog of SCRIB tumor suppressor, is associated with a stem cell signature in normal and tumoral mammary epithelia. Through in vitro and in vivo experi...
#1Trang Thi MaiH-Index: 2
#2Ahmed HamaïH-Index: 10
Last.Verónica AcevedoH-Index: 2
view all 17 authors...
Cancer stem cells are typically refractory to conventional treatments. Now, an unprecedented mechanism has been discovered by which salinomycin and derivatives can sequester iron in lysosomes leading to cytoplasmic iron depletion and the subsequent production of reactive oxygen species that are lethal to the cell. This discovery of the importance of iron in cancer stem cell maintenance provides an opportunity for developing new therapeutics.
During malignant transformation, the ability of mammary epithelial cells to cope with oncogene-induced DNA damage and avoid chromosomal instability is determined by stemness-related expression of the canonical epithelial-to-mesenchymal transition transcription factor ZEB1 and its target MSRB3, a methionine sulfoxide reductase involved in antioxidant defense.
#1Rita El Helou (AMU: Aix-Marseille University)H-Index: 2
#2Guillaume Pinna (University of Paris-Sud)H-Index: 2
Last.Bernard Mari (University of Nice Sophia Antipolis)H-Index: 38
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Summary Breast cancer stem cells (bCSCs) have been implicated in tumor progression and therapeutic resistance; however, the molecular mechanisms that define this state are unclear. We have performed two microRNA (miRNA) gain- and loss-of-function screens to identify miRNAs that regulate the choice between bCSC self-renewal and differentiation. We find that micro-RNA (miR)-600 silencing results in bCSC expansion, while its overexpression reduces bCSC self-renewal, leading to decreased in vivo tum...
Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA In the developping area of personnalized medicine, targeted therapies are mainly based on genomic characterization of each tumor, and is currently proposed as promising strategies for resistant breast cancer (RBC). Despite the promises of advanced genome sequencing, many patients still fail therapy, resulting in disease progression, recurrence, and metastases. Cancer stem cells (CSCs) concept illustrates the non-gene...
#1Rita El HelouH-Index: 2
#2Julien WicinskiH-Index: 12
Last.Christophe GinestierH-Index: 43
view all 10 authors...
Self-renewal and differentiation are two epigenetic programs that regulate stem cells fate. Dysregulation of these two programs leads to the development of cancer stem cells (CSCs). Recent evidence suggests that CSCs are relatively resistant to conventional therapies and responsible for metastasis formation. Deciphering these processes will help understand oncogenesis and allow the development of new targeted therapies. Here, we have used a whole genome promoter microarray to establish the DNA m...
#1Rita E. Helou (French Institute of Health and Medical Research)
#2Julien Wicinski (French Institute of Health and Medical Research)H-Index: 12
Last.Christophe Ginestier (French Institute of Health and Medical Research)H-Index: 43
view all 10 authors...
Pluripotency of stem cells depends on epigenetic programs that regulate self-renewal and differentiation. During oncogenesis, dysregulation of these two programs leads to the development of cancer stem cells (CSCs). Recent evidence suggests that CSCs are relatively resistant to conventional therapies and responsible for metastasis formation. Deciphering these processes will help gain insight into oncogenesis and allow the development of new targeted therapies. We used a whole-genomic promoter mi...
#1Christophe Ginestier (French Institute of Health and Medical Research)H-Index: 43
#2Danae Lartigue (French Institute of Health and Medical Research)
Last.Max Chaffanet (French Institute of Health and Medical Research)H-Index: 37
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Although advances have been made in the treatment of localized breast cancer, there has been less progress in the treatment of advanced metastatic disease. This disease is an oncoming therapeutic challenge for breast cancer since it is always fatal. Conventional therapies may fail to target cancer stem cells (CSC). Metastatic breast cancer may thus benefit from current intensive research in the CSC field. Several studies suggest that CSCs are the only cancer cells responsible for metastasis form...
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