David Viola
University of Pisa
EndocrinologyCarcinomaThyroid cancerThyroidMedicine
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Publications 76
#1Carlotta GianiH-Index: 6
#2Liborio TorregrossaH-Index: 17
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To compare the epidemiological, clinical, and pathological features of follicular (FVPTC) and classical (CVPTC) variants of papillary thyroid cancer and to correlate their outcomes according to different features. Retrospective analysis of FVPTC and CVPTC patients selected at the moment of surgical treatment from 1999 to 2004, with a median follow-up of 15 years. Several significant differences were found between FVPTC and CVPTC such as the mean age at diagnosis, the presence of tumor capsule, t...
#1Laura ValerioH-Index: 6
#2Valeria BotticiH-Index: 18
Last. Rossella EliseiH-Index: 66
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#1Antonio MatroneH-Index: 7
#2Carla GambaleH-Index: 1
Last. Rossella EliseiH-Index: 66
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Abstract Objective: In intermediate risk DTC (IR-DTC) patients, selective use of radioiodine (131-I) for remnant ablation and/or as adjuvant therapy (RRA) is advocated. The recently suggested post-...
#1Kyeong J. Kim (KU: Korea University)
#2Sin G. Kim (KU: Korea University)
Last. Mingzhao Xing (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 15
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Abstract Introduction Conservative active surveillance has been proposed for low-risk papillary thyroid microcarcinoma (PTMC), defined as ≤1.0 cm and lacking clinical aggressive features, but controversy exists with accepting it as not all such PTMCs are uniformly destined for benign prognosis. This study investigated whether BRAF V600E status could further risk stratify PTMC, particularly low-risk PTMC, and can thus help with more accurate case selection for conservative management. Methods Thi...
#1Raffaele CiampiH-Index: 22
#2Cristina RomeiH-Index: 37
Last. Rossella EliseiH-Index: 66
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Summary Sporadic Medullary Thyroid Carcinoma (sMTC) is a rare but aggressive thyroid tumor. RET and RAS genes are present in about 50%–80% of cases, but most of the remaining cases are still orphan of a genetic driver. We studied the largest series of sMTC by deep sequencing to define the mutational landscape. With this methodology we greatly reduced the number of RET- or RAS-negative cases and we confirmed the central role of RET and RAS mutations. Moreover, we highlighted the bad prognostic ro...
2 CitationsSource
CONTEXT: The dramatic rise in the incidence of thyroid cancer over the last 30 years is largely attributable to the increasing diagnosis of papillary microcarcinomas (mPTCs). Current guidelines endorse an observational management approach in properly selected cases. OBJECTIVE: To evaluate the feasibility of active surveillance in mPTC in Italy, its impact on real life, and to identify risk factors of progression. DESIGN AND SETTING: In 2014 we started a prospective-observational study of active ...
2 CitationsSource
#1Eleonora MolinaroH-Index: 33
#2David ViolaH-Index: 16
Last. Rossella EliseiH-Index: 66
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Background. The tyrosine kinase inhibitors (TKIs) are indicated for the treatment of locally advanced or metastatic progressive thyroid carcinoma (CDT), refractory to radioactive iodine. The following report describes the efficacy of lenvatinib administered through a nose-gastric tube (SNG) in a patient affected with a poorly differentiated thyroid carcinoma (PDTC) which determined a stenosis of the esophagus. Material and Methods. A patient was followed up for papillary thyroid carcinoma follic...
#1Rossella EliseiH-Index: 66
#2Alessia TacitoH-Index: 8
Last. Cristina RomeiH-Index: 37
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Background: Pathogenic germline mutations affecting the RET proto-oncogene underlie the development of hereditary medullary thyroid carcinoma (MTC). The aims of this study were to evaluate the prevalence of germline RET mutations in a large series of MTC, collected over the last 25 years, and to reappraise their clinical significance. Methods: We performed RET genetic screening in 2031 Italian subjects: patients who presented with sporadic (n = 1264) or hereditary (n = 117) MTC, plus 650 relativ...
1 CitationsSource
#1Konstantinos A. Toulis (University of Birmingham)H-Index: 9
#2David Viola (UniPi: University of Pisa)H-Index: 16
Last. Krishnarajah Nirantharakumar (HealthPartners)H-Index: 16
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#1Rossella Elisei (UniPi: University of Pisa)H-Index: 66
#2Antonio Matrone (UniPi: University of Pisa)H-Index: 7
Last. Cristina Romei (UniPi: University of Pisa)H-Index: 37
view all 15 authors...