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Jason M. Tarkin
University of Cambridge
61Publications
11H-index
922Citations
Publications 63
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#1Jason M. Tarkin (University of Cambridge)H-Index: 11
#2Deepa Gopalan (Imperial College Healthcare)H-Index: 4
Last.Justin C. Mason (NIH: National Institutes of Health)H-Index: 45
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#1Jason M. TarkinH-Index: 11
#2James Harvey RuddH-Index: 5
Last.James H. F. RuddH-Index: 2
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#1Jason M. TarkinH-Index: 11
#2Justin C. Mason (Imperial College London)H-Index: 45
Last.Zahi A. Fayad (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 90
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Mechanisms underlying atherosclerotic plaque rupture are complex and unpredictable by any current imaging test. However, several key pathogenic processes known to increase the likelihood of an acute plaque event can be tracked in vivo using positron emission tomography (PET). In their Heart paper, Jenkins et al 1 examine the utility of 18F-fluciclatide, an αvβ3integrin-binding PET tracer, for imaging atherosclerosis. This intriguing study adds great momentum in the push to identify novel methods...
1 CitationsSource
#1Rouchelle Sriranjan (University of Cambridge)H-Index: 1
#2Jason M. Tarkin (University of Cambridge)H-Index: 11
Last.James H.F. Rudd (University of Cambridge)H-Index: 43
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#1Jason M. Tarkin (University of Cambridge)H-Index: 11
#2Virginia Wolstenholme (St Bartholomew's Hospital)
Last.Charlotte Manisty (UCL: University College London)H-Index: 18
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#2Jason M. Tarkin (University of Cambridge)H-Index: 11
Last.Patrick A. CoughlinH-Index: 13
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Abstract Objectives This study determined whether in vivo positron emission tomography (PET) of arterial inflammation ( 18 F-fluorodeoxyglucose [ 18 F-FDG]) or microcalcification ( 18 F-sodium fluoride [ 18 F-NaF]) could predict restenosis following PTA. Background Restenosis following lower limb percutaneous transluminal angioplasty (PTA) is common, unpredictable, and challenging to treat. Currently, it is impossible to predict which patient will suffer from restenosis following angioplasty. Me...
1 CitationsSource
Myocardial infarction (MI) healing occurs in 2 phases: first an inflammatory phase, where clearance of necrotic debris occurs, followed by a reparative phase characterized by angiogenesis, granulation tissue formation, and attempts to repair the extracellular matrix. While efficient healing relies
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#1Xue Wang (University of Cambridge)
#2Elizabeth P.V. Le (University of Cambridge)H-Index: 2
Last.James H.F. Rudd (University of Cambridge)H-Index: 43
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Objectives To estimate the prevalence of non-calcified coronary artery disease (CAD) in patients with suspected stable angina and a zero coronary artery calcification (CAC) score, and to assess the prognostic significance of a zero CAC in these symptomatic patients. Methods In this prospective cohort study, consecutive patients with stable chest pain underwent CAC scoring ± CT coronary angiography (CTCA) as part of routine clinical care at a single tertiary centre over 7 years. Major adverse car...
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#1Jason M. Tarkin (University of Cambridge)H-Index: 11
#2Marc R. Dweck (Edin.: University of Edinburgh)H-Index: 31
Last.James H.F. Rudd (University of Cambridge)H-Index: 43
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### Learning objectives Many cardiovascular drugs in the pipeline will fail to demonstrate a clear clinical benefit when evaluated in large-scale clinical outcome trials, which are costly, require lengthy follow-up and can potentially expose patients to unforeseen risks. There exists an enormous gap between early mechanistic studies demonstrating proof-of-principle drug efficacy in preclinical models and successful translation of these therapies into everyday clinical practice. To help overcome ...
1 CitationsSource
#1Jason M. Tarkin (University of Cambridge)H-Index: 11
#2Elizabeth P.V. Le (University of Cambridge)H-Index: 2
Last.J H F Rudd (University of Cambridge)H-Index: 1
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