Andrew Bahn
University of Otago
Organic anion transporter 1EndocrinologyChemistryKidneyBiochemistry
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Publications 47
#1Rosalind F. Cook (University of Otago)H-Index: 3
#2Carol T. Bussey (University of Otago)H-Index: 5
Last. Regis R. Lamberts (University of Otago)H-Index: 14
view all 7 authors...
1 CitationsSource
#1Carol T. Bussey (University of Otago)H-Index: 5
#2H. P. Aye Thaung (University of Otago)H-Index: 2
Last. Regis R. Lamberts (University of Otago)H-Index: 14
view all 5 authors...
2 CitationsSource
#1Febbie Sangkop (University of Otago)H-Index: 1
#2Geeta Singh (University of Otago)H-Index: 1
Last. Andrew Bahn (University of Otago)H-Index: 21
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Elevated serum uric acid (SUA) or urate is associated with inflammation and gout. Recent evidence has linked urate to cancers, but little is known about urate effects in prostate cancer. Activins are inflammatory cytokines and negative growth regulators in the prostate. A hallmark of prostate cancer progression is activin insensitivity; however, mechanisms underlying this are unclear. We propose that elevated SUA is associated with prostate cancer counteracting the growth inhibitory effects of a...
5 CitationsSource
Last. Andrew BahnH-Index: 21
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#1H. P. Aye Thaung (University of Otago)H-Index: 2
#2J. Chris Baldi (University of Otago)H-Index: 5
Last. Regis R. Lamberts (University of Otago)H-Index: 14
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Elevated sympathetic nerve activity (SNA) coupled with dysregulated β-adrenoceptor (β-AR) signaling is postulated as a major driving force for cardiac dysfunction in patients with type 2 diabetes; however, cardiac SNA has never been assessed directly in diabetes. Our aim was to measure the sympathetic input to and the β-AR responsiveness of the heart in the type 2 diabetic heart. In vivo recording of SNA of the left efferent cardiac sympathetic branch of the stellate ganglion in Zucker diabetic ...
13 CitationsSource
#1H. P. Aye Thaung (University of Otago)H-Index: 2
#2Yimin Yao (University of Otago)H-Index: 2
Last. Regis R. Lamberts (University of Otago)H-Index: 14
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New Findings What is the central question of this study? Can bilateral renal denervation, an effective antihypertensive treatment in clinical and experimental studies, improve cardiac β-adrenoceptor responsiveness in a diabetic model with underlying hypertension? What is the main finding and its importance? Bilateral renal denervation did not affect β-adrenergic responsiveness in the diabetic hypertensive rat heart, but denervation reduced the hypertension-induced concentric hypertrophic remodel...
7 CitationsSource
#1Nima PurvisH-Index: 1
#2Andrew BahnH-Index: 21
Last. Rajesh Katare (University of Otago)H-Index: 32
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Stem cells are considered as the next generation drug treatment in patients with cardiovascular disease who are resistant to conventional treatment. Among several stem cells used in the clinical setting, cardiac stem cells (CSCs) which reside in the myocardium and epicardium of the heart have been shown to be an effective option for the source of stem cells. In normal circumstances, CSCs primarily function as a cell store to replace the physiologically depleted cardiovascular cells, while under ...
9 CitationsSource
#1Claudia Knake (University of Otago)H-Index: 1
#2Lisa K. Stamp (University of Otago)H-Index: 38
Last. Andrew Bahn (University of Otago)H-Index: 21
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Abstract Gout patients receiving a combination of allopurinol and furosemide require higher allopurinol doses to achieve the target serum urate (SU) of In silico analysis identified miR-448 as a potential XO-regulator, whose expression level in HepG2 cells was examined by qPCR. Fluorimetric experiments revealed no direct interactions between XO and furosemide, nor did the combination of oxypurinol/furosemide alter the XO inhibition profile of oxypurinol. In HepG2 cells, we found a significant de...
9 CitationsSource
#1Ingrid Fomison-Nurse (University of Otago)H-Index: 4
#2P. Saxena (Dunedin Public Hospital)
Last. Rajesh Katare (University of Otago)H-Index: 32
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Background: Secondary prevention medications (aspirin, other anti-platelet agents, statins, beta-blockers, angiotensin converting enzyme-inhibitors/angiotensin receptor blockers (ACE-I/ARBs)) following an Acute Coronary Syndrome (ACS) improve patients’ (pt) prognosis. The first National ACS audit (2002) identified a limited uptake of these medications. Subsequent audits in 2007 and 2012 allow comparison of the prescription rates over a decade. Methods: Over 14 days, in May 2002, 2007 and 2012, p...
#1Regis R. Lamberts (University of Otago)H-Index: 14
#2Shivanjali J Lingam (University of Otago)H-Index: 1
Last. Peter P. Jones (University of Otago)H-Index: 14
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Background Diastolic dysfunction is a key factor in the development and pathology of cardiac dysfunction in diabetes, however the exact underlying mechanism remains unknown, especially in humans. We aimed to measure contraction, relaxation, expression of calcium-handling proteins and fibrosis in myocardium of diabetic patients with preserved systolic function.
17 CitationsSource