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Kevin G. Bath
Brown University
60Publications
31H-index
4,195Citations
Publications 58
Newest
#1Alexandra Bunda (UNH: University of New Hampshire)
#2Brianna LaCarubba (UNH: University of New Hampshire)
Last.Arturo Andrade (UNH: University of New Hampshire)H-Index: 13
view all 8 authors...
Presynaptic CaV2.2 channels control calcium entry that triggers neurotransmitter release at both central and peripheral synapses. The Cacna1b gene encodes the α1-pore forming subunit of CaV2.2 channels. Distinct subsets of splice variants of CaV2.2 derived from cell-specific alternative splicing of the Cacna1b pre-mRNA are expressed in specific subpopulations of neurons. Four cell-specific sites of alternative splicing in Cacna1b that alter CaV2.2 channel function have been described in detail: ...
1 CitationsSource
#1Bénédicte Ballanger (French Institute of Health and Medical Research)H-Index: 21
#2Kevin G. Bath (Brown University)H-Index: 31
Last.Nathalie Mandairon (French Institute of Health and Medical Research)H-Index: 6
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Abstract Anxiety disorders represent one of the most common classes of psychiatric disorders. In the aging population and for patients with age-related pathology, the percentage of people suffering of anxiety is significantly elevated. Further, anxiety carries with it an increased risk for a variety of age-related medical conditions, including cardiovascular disease, stroke, cognitive decline, and increased severity of motor symptoms in Parkinson’s disease. A variety of anxiolytic compounds are ...
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#1Meghan Gallo (Brown University)H-Index: 3
#2Daniel G. Shleifer (Brown University)H-Index: 1
Last.Kevin G. Bath (Brown University)H-Index: 31
view all 7 authors...
Early life adversity (ELA) is associated with altered neural development and increased risk for the development of psychopathology across the lifespan. Rodent models of ELA are an important tool for investigating the possible mechanistic underpinnings of pathology development. We used a limited bedding and nesting model (LBN) to induce stress in the dam and alter dam-pup interactions during a sensitive period in early postnatal development. The primary characteristics previously identified in th...
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#1Heather C. Brenhouse (NU: Northeastern University)H-Index: 19
#2Kevin G. Bath (Brown University)H-Index: 31
Abstract Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiological differences can mediate risk and resilience has proven difficult in population based studies. Use of animal models provides a powerful toolset to isolate key variabl...
1 CitationsSource
Last.Kevin G. BathH-Index: 31
view all 7 authors...
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#1Haley L. Goodwill (Brown University)H-Index: 4
#2Gabriela Manzano-Nieves (Brown University)H-Index: 4
Last.Kevin G. Bath (Brown University)H-Index: 31
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Childhood trauma and neglect influence emotional development and increase the risk for and severity of mental illness. Women have a heightened susceptibility to the effects of early life stress (ELS) and are twice as likely as men to develop debilitating, stress-associated disorders later in life, such as major depressive disorder (MDD). Until now, mouse models of depression have been largely unsuccessful at replicating the diverse symptomatology of this disease and the sex bias in vulnerability...
17 CitationsSource
#1Gabriela Manzano Nieves (Brown University)H-Index: 1
#2Arielle Schilit Nitenson (Brown University)H-Index: 3
Last.Kevin G. Bath (Brown University)H-Index: 31
view all 8 authors...
In humans, some forms of early life stress (ELS) have been linked with precocious puberty, altered brain maturation, and increased risk for a variety of forms of pathology. Interestingly, not all forms of ELS have been found to equally impact these metrics of maturation. In recent work, we have found that ELS in the form of limited bedding (LB) from P4 to P11, was associated with precocious hippocampus maturation in males and increased risk for depressive-like pathology and attentional disturban...
3 CitationsSource
#1Haley L. Goodwill (Brown University)H-Index: 4
#2Gabriela Manzano-Nieves (Brown University)H-Index: 4
Last.Kevin G. Bath (Brown University)H-Index: 31
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Summary Poverty, displacement, and parental stress represent potent sources of early life stress (ELS). Stress disproportionately affects females, who are at increased risk for stress-related pathologies associated with cognitive impairment. Mechanisms underlying stress-associated cognitive impairment and enhanced risk of females remain unknown. Here, ELS is associated with impaired rule-reversal (RR) learning in females, but not males. Impaired performance was associated with decreased expressi...
5 CitationsSource
#1Dylan G. Gee (Yale University)H-Index: 24
#2Kevin G. Bath (Brown University)H-Index: 31
Last.Catherine A. Hartley (NYU: New York University)H-Index: 18
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The ability to anticipate and respond appropriately to the challenges and opportunities present in our environments is critical for adaptive behavior. Recent methodological innovations have led to substantial advances in our understanding of the neurocircuitry supporting such motivated behavior in adulthood. However, the neural circuits and cognitive processes that enable threat- and reward-motivated behavior undergo substantive changes over the course of development, and these changes are less ...
3 CitationsSource
#1Gabriela Manzano-Nieves (Brown University)H-Index: 4
#2Mizan Gaillard (Brown University)H-Index: 1
Last.Kevin G. Bath (Brown University)H-Index: 31
view all 4 authors...
4 CitationsSource
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