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Kevin G. Bath
Brown University
PsychologyNeurotrophic factorsNeuroscienceBrain-derived neurotrophic factorBiology
63Publications
32H-index
4,547Citations
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Publications 61
Newest
#1Camila Demaestri (Brown University)
#2Tracy Pan (Brown University)
Last. Kevin G. Bath (Brown University)H-Index: 32
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Abstract Early life adversity (ELA) increases risk for negative health outcomes, with sex disparities in prevalence and form of ELA experienced and risk for neuropsychiatric pathology. ELA comes in many forms (e.g. parental neglect/loss, limited access to resources) but whether disparate forms of ELA have common effects on outcomes, and if males and females are equally affected, remains unknown. Epidemiological studies often fail to accurately account for differences in type, timing, and duratio...
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Sex as a biological variable (SABV) is critical for understanding the broad range of physiological, neurobiological, and behavioral consequences of early life adversity (ELA). The study of the interaction of SABV and ELA ties into several current debates, including the importance of taking into account SABV in research, differing strategies employed by males and females in response to adversity, and the possible evolutionary and developmental mechanisms of altered development in response to adve...
2 CitationsSource
#1Gabriela Manzano Nieves (Brown University)H-Index: 1
#2Marilyn Bravo (Brown University)H-Index: 1
Last. Kevin G. Bath (Brown University)H-Index: 32
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Resource insecurity (e.g., poverty) can be a significant source of stress. Decreased resources during childhood has been associated with increased risk for developing stress-related disorders, including major depressive disorder and anxiety Although the link between early life adversity and increased risk for psychopathology has been well established, the developmental mechanisms remain unclear. Using a mouse model of poverty-like rearing, limited bedding and nesting materials (LB), we tested th...
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#1Arielle Schilit Nitenson (Brown University)H-Index: 3
#2Gabriela Manzano Nieves (Brown University)H-Index: 1
Last. Kevin G. Bath (Brown University)H-Index: 32
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Summary Learning to perceptually discriminate between chemical signals in the environment [olfactory perceptual learning (OPL)] is critical for survival. Multiple mechanisms have been implicated in olfactory perceptual learning, including modulation of neurogenesis and manipulation of cholinergic activity. However, whether these represent distinct processes regulating OPL or if cholinergic effects on OPL depend upon neurogenesis has remained an unresolved question. Using a combination of pharmac...
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#1Alexandra Bunda (UNH: University of New Hampshire)H-Index: 2
#2Brianna LaCarubba (UNH: University of New Hampshire)H-Index: 2
Last. Arturo Andrade (UNH: University of New Hampshire)H-Index: 15
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Presynaptic CaV2.2 channels control calcium entry that triggers neurotransmitter release at both central and peripheral synapses. The Cacna1b gene encodes the α1-pore forming subunit of CaV2.2 channels. Distinct subsets of splice variants of CaV2.2 derived from cell-specific alternative splicing of the Cacna1b pre-mRNA are expressed in specific subpopulations of neurons. Four cell-specific sites of alternative splicing in Cacna1b that alter CaV2.2 channel function have been described in detail: ...
2 CitationsSource
#1Meghan Gallo (Brown University)H-Index: 4
#2Daniel G. Shleifer (Brown University)H-Index: 1
Last. Kevin G. Bath (Brown University)H-Index: 32
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Early life adversity (ELA) is associated with altered neural development and increased risk for the development of psychopathology across the lifespan. Rodent models of ELA are an important tool for investigating the possible mechanistic underpinnings of pathology development. We used a limited bedding and nesting model (LBN) to induce stress in the dam and alter dam-pup interactions during a sensitive period in early postnatal development. The primary characteristics previously identified in th...
2 CitationsSource
#1Bénédicte Ballanger (French Institute of Health and Medical Research)H-Index: 21
#2Kevin G. Bath (Brown University)H-Index: 32
Last. Nathalie Mandairon (French Institute of Health and Medical Research)H-Index: 5
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Abstract Anxiety disorders represent one of the most common classes of psychiatric disorders. In the aging population and for patients with age-related pathology, the percentage of people suffering of anxiety is significantly elevated. Further, anxiety carries with it an increased risk for a variety of age-related medical conditions, including cardiovascular disease, stroke, cognitive decline, and increased severity of motor symptoms in Parkinson’s disease. A variety of anxiolytic compounds are ...
2 CitationsSource
#1Heather C. Brenhouse (NU: Northeastern University)H-Index: 20
#2Kevin G. Bath (Brown University)H-Index: 32
Abstract Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiological differences can mediate risk and resilience has proven difficult in population based studies. Use of animal models provides a powerful toolset to isolate key variabl...
7 CitationsSource
#1Haley L. Goodwill (Brown University)H-Index: 4
#2Gabriela Manzano-Nieves (Brown University)H-Index: 5
Last. Kevin G. Bath (Brown University)H-Index: 32
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Childhood trauma and neglect influence emotional development and increase the risk for and severity of mental illness. Women have a heightened susceptibility to the effects of early life stress (ELS) and are twice as likely as men to develop debilitating, stress-associated disorders later in life, such as major depressive disorder (MDD). Until now, mouse models of depression have been largely unsuccessful at replicating the diverse symptomatology of this disease and the sex bias in vulnerability...
34 CitationsSource
#1Gabriela Manzano Nieves (Brown University)H-Index: 1
#2Arielle Schilit Nitenson (Brown University)H-Index: 3
Last. Kevin G. Bath (Brown University)H-Index: 32
view all 8 authors...
In humans, some forms of early life stress (ELS) have been linked with precocious puberty, altered brain maturation, and increased risk for a variety of forms of pathology. Interestingly, not all forms of ELS have been found to equally impact these metrics of maturation. In recent work, we have found that ELS in the form of limited bedding (LB) from P4 to P11, was associated with precocious hippocampus maturation in males and increased risk for depressive-like pathology and attentional disturban...
10 CitationsSource
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