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Koert N.J. Burger
Utrecht University
59Publications
34H-index
3,662Citations
Publications 59
Newest
#2Sergei S. Pilyugin (UF: University of Florida)H-Index: 19
Last.Alexander A. MironovH-Index: 26
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Membrane organelles often have complicated shapes and differ in their volume, surface area and membrane curvature. The ratio between the surface area of the cytosolic and luminal leaflets (trans-membrane area asymmetry (TAA)) determines the membrane curvature within different sites of the organelle. Thus, the shape of the organelle could be critically dependent on TAA. Here, using mathematical modeling and stereological measurements of TAA during fast transformation of organelle shapes, we prese...
#1Sewwandi S. Rathnayake (KSU: Kent State University)H-Index: 2
#2Mona Mirheydari (KSU: Kent State University)H-Index: 4
Last.David Vaknin (Iowa State University)H-Index: 29
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Neutral lipid transport in mammals is complicated involving many types of apolipoprotein. The exchangeable apolipoproteins mediate the transfer of hydrophobic lipids between tissues and particles, and bind to cell surface receptors. Amphipathic a-helices form a common structural motif that facilitates their lipid binding and exchangeability. ApoLp-III, the only exchangeable apolipoprotein found in insects, is a model amphipathic a:helix bundle protein and its three dimensional structure and func...
#1Koert N.J. Burger (UU: Utrecht University)H-Index: 34
#2Joline W.J. Beulens (UU: Utrecht University)H-Index: 48
Last.Claus Dethlefsen (Aarhus University Hospital)H-Index: 24
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Background: Dietary fiber, carbohydrate quality and quantity are associated with mortality risk in the general population. Whether this is also the case among diabetes patients is unknown. Objective: To assess the associations of dietary fiber, glycemic load, glycemic index, carbohydrate, sugar, and starch intake with mortality risk in individuals with diabetes. Methods: This study was a prospective cohort study among 6,192 individuals with confirmed diabetes mellitus (mean age of 57.4 years, an...
#1Sewwandi S. Rathnayake (KSU: Kent State University)H-Index: 2
#2Adam T. Schulte (KSU: Kent State University)H-Index: 1
Last.Edgar E. Kooijman (KSU: Kent State University)H-Index: 16
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Amphipathic α-helix bundle domains are found in many proteins responsible for neutral lipid transport and storage. Important examples are found in apoE, the perilipins, and the representative exchangeable apolipoprotein apoLp-III. Here we characterized the organization and lipid interaction of apoLp-III in Langmuir monolayers modeling the phospholipid monolayer surrounding the neutral lipid particle, i.e. lipoprotein. Surface-sensitive X-ray techniques showed that apoLp-III is partially unfolded...
#1Koert N.J. Burger (UU: Utrecht University)H-Index: 34
#2Joline W.J. Beulens (UU: Utrecht University)H-Index: 48
Last.Daphne L. van der AH-Index: 41
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Background The associations of glycemic load (GL) and glycemic index (GI) with the risk of cardiovascular diseases (CVD) are not well-established, particularly in men, and may be modified by gender. Objective To assess whether high dietary GL and GI increase the risk of CVD in men and women. Methods A large prospective cohort study (EPIC-MORGEN) was conducted within the general Dutch population among 8,855 men and 10,753 women, aged 21–64 years at baseline (1993–1997) and free of diabetes and CV...
#1Edgar E. Kooijman (KSU: Kent State University)H-Index: 16
#2Koert N.J. Burger (UU: Utrecht University)H-Index: 34
Phosphatidic acid is the simplest (diacyl)glycerophospholipid present in cells and is now a well established second messenger with direct biological functions. It is specifically recognized by diverse proteins and plays an important role in cellular signaling and membrane dynamics in all eukaryotes. An important determinant of the biological functions of phosphatidic acid is its anionic headgroup. In this review we will focus on the peculiar ionization properties of phosphatidic acid and their c...
#1Mischa BonnH-Index: 57
#2Michiel Mueller (UvA: University of Amsterdam)H-Index: 33
Last.Koert N.J. Burger (UU: Utrecht University)H-Index: 34
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Cellular lipid droplets are organelles that carry out important functions such as the regulated storage and release of cholesterol and fatty acids (FAs). Lipid droplets therefore play a key role in both healthy metabolism and metabolic disorders such as obesity, type II diabetes, and atherosclerosis. Hence, there has been much interest in understanding the chemical (lipid) composition and physical state (lipid packing) of lipid droplets. Coherent anti-Stokes Raman Scattering (CARS) microscopy ha...
TIP47 (tail-interacting protein of 47 kD) was characterized as a cargo selection device for mannose 6-phosphate receptors (MPRs), directing their transport from endosomes to the trans-Golgi network. In contrast, our current analysis shows that cytosolic TIP47 is not recruited to organelles of the biosynthetic and endocytic pathways. Knockdown of TIP47 expression had no effect on MPR distribution or trafficking and did not affect lysosomal enzyme sorting. Therefore, our data argue against a funct...
#1Edgar E. Kooijman (KSU: Kent State University)H-Index: 16
#2David Vaknin (Iowa State University)H-Index: 29
Last.Satyendra Kumar (KSU: Kent State University)H-Index: 50
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Transport of fat in the bloodstream is mediated by lipoprotein particles. These hydrophobic particles are covered by a (phospho-)lipid monolayer and further stabilized by exchangeable apolipoproteins. Their amphipatic helix bundle is thought to unfold upon interaction with the (phospho)lipid monolayer. The dynamics of this interaction at lipid interfaces has not been directly shown experimentally. Here we report on the structure of monolayers formed by a representative exchangeable apolipoprotei...
#1Hilde A. Rinia (UvA: University of Amsterdam)H-Index: 8
#2Koert N.J. Burger (UU: Utrecht University)H-Index: 34
Last.Michiel Mueller (UvA: University of Amsterdam)H-Index: 33
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Lipid droplets (LDs) are highly dynamic organelles that perform multiple functions, including the regulated storage and release of cholesterol and fatty acids. Information on the molecular composition of individual LDs within their cellular context is crucial in understanding the diverse biological functions of LDs, as well as their involvement in the development of metabolic disorders such as obesity, type II diabetes, and atherosclerosis. Although ensembles of LDs isolated from cells and tissu...
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