Timothy R. Fennell
Research Triangle Park
Publications 128
#1Matthew J. Mazzella (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 12
#2Matthew J. Mazzella (ISMMS: Icahn School of Medicine at Mount Sinai)
Last.Wimal Pathmasiri (UNC: University of North Carolina at Chapel Hill)H-Index: 6
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With advances in technologies that facilitate metabolome-wide analyses, the incorporation of metabolomics in the pursuit of biomarkers of exposure and effect is rapidly evolving in population health studies. However, many analytic approaches are limited in their capacity to address high-dimensional metabolomics data within an epidemiologic framework, including the highly collinear nature of the metabolites and consideration of confounding variables. In this Children’s Health Exposure Analysis Re...
Abstract We summarize the literature involving the deposition of nanomaterials within the placenta following oral exposure and the biological interactions between nanomaterials and placental development and function. The review focuses on the oral exposure of metal and metal oxide engineered nanomaterials (ENMs), carbon-based ENMs, and nanoplastics in animal models, with a minor discussion of intravenous injections. Although the literature suggests that the placenta is an efficient barrier in pr...
#1Suramya Waidyanatha (NIH: National Institutes of Health)H-Index: 31
#2Sherry R. Black (RTP: Research Triangle Park)H-Index: 7
Last.Timothy R. Fennell (RTP: Research Triangle Park)H-Index: 30
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#1Ninell P. Mortensen (RTI International)H-Index: 9
#2Ninell P. Mortensen (RTI International)H-Index: 1
Last.Timothy R. Fennell (RTI International)H-Index: 30
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Infants born with neonatal abstinence syndrome increased 5-fold between 2000 and 2012. Prenatal exposure to opioids has been linked to altered brain development, congenital heart defects, neural tube defects, and clubfoot. In the study presented here, placental transfer rate of six opioids; morphine, heroin, fentanyl, methadone, oxycodone, and naloxone was compared in vitro using a human trophoblast cell monolayer model, BeWo b30. The rate and concentration of opioid translocation were investiga...
Abstract We investigated the toxicokinetics and bioavailability of bisphenol AF (BPAF) in male and female Harlan Sprague Dawley rats and B6C3F1/N mice following a single gavage administration of 34, 110, or 340 mg/kg. A validated analytical method was used to quantitate free (unconjugated parent) and total (unconjugated and conjugated) BPAF in plasma. BPAF was rapidly absorbed in rats with the maximum plasma concentration, C max , of free BPAF reached at ≤2.20 h. BPAF was cleared rapidly with a ...
#1Natasha R. Catlin (NIH: National Institutes of Health)H-Index: 2
#2Suramya Waidyanatha (NIH: National Institutes of Health)H-Index: 31
Last.Timothy R. Fennell (RTP: Research Triangle Park)H-Index: 30
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AbstractTris(4-chlorophenyl)methane (TCPME) and tris(4-chlorophenyl)methanol (TCPMOH) have been detected in various biota and human tissues.The current studies were undertaken to investigate the disposition and metabolism of TCPME and TCPMOH in rats and mice.[14C]TCPME was well absorbed (≥66%) in male rats and mice following a single oral administration of 1, 10, or 100 mg/kg. The excretion of [14C]TCPME-derived radioactivity in urine (≤2.5%) and feces (≤18%) was low. The administered dose was r...