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Timothy R. Fennell
Research Triangle Park
EndocrinologyChemistryUrineBiochemistryMetabolism
127Publications
30H-index
3,145Citations
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Publications 126
Newest
#1Suramya Waidyanatha (NIH: National Institutes of Health)H-Index: 31
#2Sherry R. Black (RTP: Research Triangle Park)H-Index: 8
Last. Timothy R. Fennell (RTP: Research Triangle Park)H-Index: 30
view all 7 authors...
1 CitationsSource
#1Jessie Buckley (RU: Rutgers University)
#3Emily S. Barrett (RU: Rutgers University)H-Index: 20
Last. Ghassan B. Hamra (Johns Hopkins University)H-Index: 12
view all 22 authors...
The Environmental Influences on Child Health Outcomes (ECHO) Program will evaluate environmental factors affecting children’s health (perinatal, neurodevelopmental, obesity, respiratory, and positive health outcomes) by pooling cohorts composed of >50,000 children in the largest US study of its kind. Our objective was to identify opportunities for studying chemicals and child health using existing or future ECHO chemical exposure data. We described chemical-related information collected by ECHO ...
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#1Suramya Waidyanatha (NIH: National Institutes of Health)H-Index: 31
#2Sherry R. Black (RTP: Research Triangle Park)H-Index: 8
Last. Timothy R. Fennell (RTP: Research Triangle Park)H-Index: 30
view all 7 authors...
Abstract N-Butylbenzenesulfonamide (NBBS) is a plasticizer detected in the environment suggesting potential human exposure. These studies investigated the in vitro hepatic clearance and disposition of [14C]NBBS in rodents following a single gavage (2, 20 or 200 mg/kg) or intravenous (IV) administration (20 mg/kg). NBBS was cleared slower in hepatocytes from humans compared to rodents. [14C]NBBS was well-absorbed in male rats following gavage administration and excreted extensively in urine (70-7...
1 CitationsSource
#1Ninell P. MortensenH-Index: 12
Last. Timothy R. FennellH-Index: 30
view all 7 authors...
Abstract The use of engineered nanomaterials (ENMs) in foods and consumer products is rising, increasing the potential for unintentional ingestion. While the cytotoxicity of many ENMs has been investigated, less attention has been given to adverse impact on the intestinal barrier integrity. Chronical disruption of gastrointestinal integrity can have far reaching health implications. Using fully differentiated Caco-2 cells, the perturbation of intestinal barrier function and cytotoxicity were inv...
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#1Matthew J. Mazzella (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 13
#2Susan Sumner (UNC: University of North Carolina at Chapel Hill)H-Index: 31
Last. Chris Gennings (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 32
view all 11 authors...
With advances in technologies that facilitate metabolome-wide analyses, the incorporation of metabolomics in the pursuit of biomarkers of exposure and effect is rapidly evolving in population health studies. However, many analytic approaches are limited in their capacity to address high-dimensional metabolomics data within an epidemiologic framework, including the highly collinear nature of the metabolites and consideration of confounding variables. In this Children’s Health Exposure Analysis Re...
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#1Ninell P. Mortensen (RTI International)H-Index: 12
#2Leah M. Johnson (RTI International)H-Index: 12
Last. Timothy R. Fennell (RTI International)H-Index: 30
view all 5 authors...
Abstract We summarize the literature involving the deposition of nanomaterials within the placenta following oral exposure and the biological interactions between nanomaterials and placental development and function. The review focuses on the oral exposure of metal and metal oxide engineered nanomaterials (ENMs), carbon-based ENMs, and nanoplastics in animal models, with a minor discussion of intravenous injections. Although the literature suggests that the placenta is an efficient barrier in pr...
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#1Suramya Waidyanatha (NIH: National Institutes of Health)H-Index: 31
#2Sherry R. Black (RTP: Research Triangle Park)H-Index: 8
Last. Chad Blystone (NIH: National Institutes of Health)H-Index: 3
view all 10 authors...
Abstract Sulfolane is a ground water contaminant near refinery sites. The objective of this work was to investigate the toxicokinetics and bioavailability of sulfolane in male and female Harlan Hsd:Sprague Dawley® SD® rats and B6C3F1/N mice following a single oral administration of 10, 30, or 100 mg/kg. Sulfolane was rapidly absorbed in rats with the maximum plasma concentration, C max , reached at ≤1.47 h. Although C max increased proportionally to the dose, the half-life of elimination increas...
Source
#1Suramya Waidyanatha (NIH: National Institutes of Health)H-Index: 31
#2Sherry R. Black (RTP: Research Triangle Park)H-Index: 8
Last. Timothy R. Fennell (RTP: Research Triangle Park)H-Index: 30
view all 10 authors...
Abstract We investigated the toxicokinetics and bioavailability of bisphenol AF (BPAF) in male and female Harlan Sprague Dawley rats and B6C3F1/N mice following a single gavage administration of 34, 110, or 340 mg/kg. A validated analytical method was used to quantitate free (unconjugated parent) and total (unconjugated and conjugated) BPAF in plasma. BPAF was rapidly absorbed in rats with the maximum plasma concentration, C max , of free BPAF reached at ≤2.20 h. BPAF was cleared rapidly with a ...
1 CitationsSource
#1Ninell P. Mortensen (RTI International)H-Index: 12
#2Maria M Caffaro (RTI International)
Last. Timothy R. Fennell (RTI International)H-Index: 30
view all 5 authors...
Infants born with neonatal abstinence syndrome increased 5-fold between 2000 and 2012. Prenatal exposure to opioids has been linked to altered brain development, congenital heart defects, neural tu...
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#1Natasha R. Catlin (NIH: National Institutes of Health)H-Index: 2
#2Suramya Waidyanatha (NIH: National Institutes of Health)H-Index: 31
Last. Timothy R. Fennell (RTP: Research Triangle Park)H-Index: 30
view all 8 authors...
AbstractTris(4-chlorophenyl)methane (TCPME) and tris(4-chlorophenyl)methanol (TCPMOH) have been detected in various biota and human tissues.The current studies were undertaken to investigate the disposition and metabolism of TCPME and TCPMOH in rats and mice.[14C]TCPME was well absorbed (≥66%) in male rats and mice following a single oral administration of 1, 10, or 100 mg/kg. The excretion of [14C]TCPME-derived radioactivity in urine (≤2.5%) and feces (≤18%) was low. The administered dose was r...
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