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James A. Berkley
University of Oxford
242Publications
41H-index
6,772Citations
Publications 251
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#1Lior Drukker (University of Oxford)H-Index: 1
#2Eleonora Staines-Urias (University of Oxford)H-Index: 2
Last.Aris T. Papageorghiou (University of Oxford)H-Index: 54
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Abstract Background Reference values for umbilical artery Doppler indices are used clinically to assess fetal wellbeing. However, many studies that have produced reference charts have important methodological limitations, and these result in significant heterogeneity of reported reference ranges. Objectives To produce international gestational age-specific centiles for umbilical artery Doppler indices based on longitudinal data and the same rigorous methodology used in the original Fetal Growth ...
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#1Lucas Otieno (Kenya Medical Research Institute)H-Index: 13
Last.Martina Oneko (Kenya Medical Research Institute)H-Index: 10
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Abstract Background We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted in seven sub-Saharan African countries. Methods Infants 6–12 weeks and children 5–17 months old were randomized to receive 4 RTS,S/AS01 doses (R3R group), 3 RTS,S/AS01 doses plus 1 comparator vaccine dose (R3C group), or 4 comparator vaccine doses (C3C group) at study months 0, 1, 2 and 20...
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#1Charles J. Sande (University of Oxford)H-Index: 12
#2James M. Njunge (Wellcome Trust)H-Index: 4
Last.Andrew J. Pollard (University of Oxford)H-Index: 57
view all 13 authors...
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#1Alison Talbert (Wellcome Trust)H-Index: 8
#2Moses Ngari (Wellcome Trust)H-Index: 9
Last.James A. BerkleyH-Index: 41
view all 9 authors...
There is an increasing recognition that children remain at elevated risk of death following discharge from health facilities in resource-poor settings. Diarrhea has previously been highlighted as a risk factor for post-discharge mortality. A retrospective cohort study was conducted to estimate the incidence and demographic, clinical, and biochemical features associated with inpatient and 1-year post-discharge mortality amongst children aged 2–59 months admitted with diarrhea from 2007 to 2015 at...
1 CitationsSource
#1James M. Njunge (Wellcome Trust)H-Index: 4
#2Agnes Gwela (Wellcome Trust)H-Index: 2
Last.James A. Berkley (University of Oxford)H-Index: 41
view all 12 authors...
High mortality after discharge from hospital following acute illness has been observed among children with Severe Acute Malnutrition (SAM). However, mechanisms that may be amenable to intervention to reduce risk are unknown. We performed a nested case-control study among HIV-uninfected children aged 2–59 months treated for complicated SAM according to WHO recommendations at four Kenyan hospitals. Blood was drawn from 1778 children when clinically judged stable before discharge from hospital. Cas...
1 CitationsSource
#1Patricia Njuguna (Wellcome Trust)H-Index: 24
#2Kathryn Maitland (Imperial College London)H-Index: 42
Last.Philip Bejon (Wellcome Trust)H-Index: 46
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Many parts of Africa have witnessed reductions in Plasmodium falciparum transmission over the last 15 years. Since immunity to malaria is acquired more rapidly at higher transmission, the slower acquisition of immunity at lower transmission may partially offset the benefits of reductions in transmission. We examined the clinical spectrum of disease and predictors of mortality after sustained changes in transmission intensity, using data collected from 1989 to 2016. We conducted a temporal observ...
1 CitationsSource
#1Charles J. Sande (University of Oxford)H-Index: 12
#2James M. Njunge (Wellcome Trust)H-Index: 4
Last.Andrew J. Pollard (University of Oxford)H-Index: 57
view all 13 authors...
RSV infection is typically associated with secondary bacterial infection. We hypothesise that the local airway immune response to RSV has incidental antibacterial effects. Using coordinated proteomics and metagenomics analysis we simultaneously analysed the microbiota and proteomes of the upper airway and determined direct antibacterial activity in airway secretions of RSV-infected children. Here, we report that the airway abundance of Streptococcus was higher in samples collected at the time of...
2 CitationsSource
#1Joseph Bitilinyu-Bangoh (UvA: University of Amsterdam)
#2Wieger P. Voskuijl (UNIMA: University of Malawi)H-Index: 14
Last.Henk D. F. H. Schallig (UvA: University of Amsterdam)H-Index: 39
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Background There is significant need for accurate diagnostic tools for Cryptosporidium spp. and Giardia duodenalis infections in resource limited countries where diarrhoeal disease caused by these parasites is often prevalent. The present study assessed the diagnostic performance of three commercially available rapid diagnostic tests (RDTs) based on faecal-antigen detection for Cryptosporidium spp. and/or G. duodenalis infections in stool samples of children admitted with severe acute malnutriti...
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#1James A. Berkley (Wellcome Trust)H-Index: 41
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#1Claire AllenH-Index: 7
#2Jeroen JansenH-Index: 1
Last.Hannah Hafezi ('KCL': King's College London)
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Program decision-making to prevent and treat acute malnutrition in an emergency can be hampered by a lack of accessible and relevant overviews of directly available robust research evidence. There is often evidence from related settings such as from low-income countries, but this is dispersed across many databases, may be inaccessible and requires assessment of its relevance to the humanitarian setting. We describe a process whereby a multi-disciplinary, international group of specialists worked...
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