Daniel Alcolea
Autonomous University of Barcelona
PsychologyDiseaseCerebrospinal fluidDiabetes mellitusBiomarker (medicine)
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Publications 116
#1Jose L. Cantero (Pablo de Olavide University)H-Index: 30
#2Mercedes Atienza (Pablo de Olavide University)H-Index: 29
view all 13 authors...
Evidence suggests that the basal forebrain (BF) cholinergic system degenerates early in the course of Alzheimer's disease (AD), likely due to the vulnerability of BF cholinergic neurons to tau pathology. However, it remains unclear whether the presence of tauopathy is the only requirement for initiating the BF degeneration in asymptomatic subjects at risk for AD (AR-AD), and how BF structural deficits evolve from normal aging to preclinical and prodromal AD. Here, we provide human in vivo magnet...
#1Laura Cervera-Carles (Autonomous University of Barcelona)H-Index: 4
#2Oriol Dols-Icardo (Autonomous University of Barcelona)H-Index: 12
Last. Jordi Clarimón (Autonomous University of Barcelona)H-Index: 37
view all 7 authors...
Abstract A circular-transcriptome-wide study has recently linked differential expression of circular RNAs (circRNAs) in brain tissue with Alzheimer’s disease (AD). We aimed at replicating the major findings in an independent series of sporadic and familial AD. We also included cases with frontotemporal lobar degeneration (FTLD), comprising brain specimens with TDP-43 aggregates (FTLD-TDP43) and samples that presented Tau accumulation (FTLD-Tau). Using a quantitative PCR approach, we evaluated ei...
#1L. Martin-Aguilar (Hospital de Sant Pau)
Last. Laia MuñozH-Index: 6
view all 28 authors...
Objective: To study baseline serum neurofilament light chain (sNfL) levels as a prognostic biomarker in Guillain-Barre syndrome (GBS). Methods: We measured NfL using SiMoA in serum (98 samples) and CSF (24 samples) of GBS patients prospectively included in the International GBS Outcome Study (IGOS) in Spain and compared them with controls (HC). We performed multivariable regression to analyze the association between sNfL levels and functional outcome at one year. Results: GBS patients had higher...
#2Constance Delaby (University of Montpellier)H-Index: 12
Last. Sylvain Lehmann (University of Montpellier)H-Index: 49
view all 10 authors...
AbstractAlzheimer’s disease (AD) is an incurable neurodegenerative disease characterized by progressive decline of cognitive abilities. Amyloid beta peptides (Aβ), Tau proteins and the phosphorylat...
1 CitationsSource
#1Oriol Dols-Icardo (Autonomous University of Barcelona)H-Index: 12
#2Victor Montal (Autonomous University of Barcelona)H-Index: 7
Last. Laura Molina-PorcelH-Index: 17
view all 17 authors...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the degeneration of upper and lower motor neurons. A major neuropathological finding in ALS is the coexistence of glial activation and aggregation of the phosphorylated transactive response DNA-binding protein 43-kDa (pTDP43) in the motor cortex at the earliest stages of the disease. Despite this, the transcriptional alterations associated with these pathological changes in this major vulnerable brain...
#1Júlia Faura (Autonomous University of Barcelona)H-Index: 1
#2Alejandro Bustamante (Autonomous University of Barcelona)H-Index: 13
Last. Joan Montaner (Autonomous University of Barcelona)H-Index: 62
view all 17 authors...
CCL23 is a chemokine implicated in inflammation and host defense responses. It has been recently associated with acquired brain damage and stroke outcomes. In this study, we reported the role of CCL23 in Alzheimer's disease (AD). We evaluated the levels of CCL23 in 659 individuals: cognitively normal, mild cognitive impaired (MCI), and AD patients. Two cross-sectional (study 1, n = 53; study 2, n = 200) and two longitudinal (study 3, n = 74; study 4, n = 332) studies were analyzed separately. CC...
#1Ignacio Illán-Gala (Autonomous University of Barcelona)H-Index: 7
#2Jordi Pegueroles (Autonomous University of Barcelona)H-Index: 7
Last. Alberto Lleó (Autonomous University of Barcelona)H-Index: 43
view all 19 authors...
Objective We aimed to investigate the relationship between cerebrospinal fluid levels (CSF) of amyloid precursor protein (APP)‐derived peptides related to the amyloidogenic pathway, cortical thickness, neuropsychological performance, and cortical gene expression profiles in frontotemporal lobar degeneration (FTLD)‐related syndromes, Alzheimer’s disease (AD), and healthy controls.
#1Daniel Stamate (Lond: University of London)H-Index: 6
#2Min Kim (Steno Diabetes Center)
Last. Cristina Legido-Quigley (Steno Diabetes Center)
view all 45 authors...
INTRODUCTION: Machine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer9s Disease (AD). Here we set out to test the performance of metabolites in blood to categorise AD when compared to CSF biomarkers. METHODS: This study analysed samples from 242 cognitively normal (CN) people and 115 with AD-type dementia utilizing plasma metabolites (n=883). Deep Learning (DL), Extreme Gradient Boosting (XGBoost) and Random Forest (RF) were used to differentiate AD from C...
#1Liu Shi (University of Oxford)H-Index: 4
#1Liu Shi (University of Oxford)H-Index: 2
Last. Alejo J. Nevado-Holgado (University of Oxford)H-Index: 8
view all 53 authors...
Abstract Introduction Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins. Methods 4001 plasma proteins were measured in two groups of participants (discovery group = 516, replication group = 365) selected from the European Medical Information F...
#1Daniel Alcolea (Autonomous University of Barcelona)H-Index: 23
#2Jordi Pegueroles (Autonomous University of Barcelona)H-Index: 7
Last. Alberto Lleó (Autonomous University of Barcelona)H-Index: 43
view all 17 authors...
Objective To determine the cutoffs that optimized the agreement between 18F‐Florbetapir positron emission tomography (PET) and Aβ1‐42, Aβ1‐40, tTau, pTau and their ratios measured in cerebrospinal fluid (CSF) on the LUMIPULSE G600II instrument, we quantified the levels of these four biomarkers in 94 CSF samples from participants of the Sant Pau Initiative on Neurodegeneration (SPIN cohort) using the Lumipulse G System with available 18F‐Florbetapir imaging.
4 CitationsSource