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Joe M. El-Khoury
Yale University
21Publications
5H-index
142Citations
Publications 21
Newest
A 28-year-old man with a history of opioid abuse, currently prescribed Suboxone® to manage his opioid use disorder, submitted a urine specimen for a drug screen to verify abstinence from illicit compounds and compliance with the prescribed medication. The specimen screened positive by immunoassay (IA) for oxycodone and buprenorphine. Based on these results, the physician requested confirmation testing by LC-MS/MS and requested help interpreting the results (Table 1). View this table: Table 1. Pa...
#1Sherry G. Mansour (Yale University)H-Index: 4
Last.Chirag R. Parikh (Johns Hopkins University)H-Index: 63
view all 0 authors...
Background and objectives Marathon runners develop transient AKI with urine sediments and injury biomarkers suggesting nephron damage. Design, setting, participants, & measurements To investigate the etiology, we examined volume and thermoregulatory responses as possible mechanisms in runners’ AKI using a prospective cohort of runners in the 2017 Hartford Marathon. Vitals, blood, and urine samples were collected in 23 runners 1 day premarathon and immediately and 1 day postmarathon. We measured ...
#1Ahmad Charifa (Yale University)
#2Joe M. El-Khoury (Yale University)H-Index: 5
An 85-year-old man with a medical history significant for monoclonal IgM kappa gammopathy (Waldenstrom macroglobulinemia) was being evaluated for malnutrition. The serum homocysteine concentration, performed with a spectrophotometric enzymatic method (Roche cobas c701; Roche Diagnostics), was extremely high at 105.8 μmol/L (Table 1). Results for other laboratory tests were unremarkable. View this table: Table 1. Relevant laboratory results for this patient. 1. What conditions can cause increases...
#1Lidiya Kukova (Yale University)H-Index: 2
#2Sherry G. Mansour (Yale University)H-Index: 4
Last.Chirag R. Parikh (Johns Hopkins University)H-Index: 63
view all 8 authors...
Background: Protein detection assays are invaluable tools in the field of biomarker discovery. However, only immunoassays are widely used and can measure 10–20 analytes per biosample. The novel SOMAmer-based assay uses nucleotide aptamer technology to measure over 1300 analytes per biosample. We compared the SOMAmer-based platform to traditional approaches to quantify analytes in a clinical setting with paired samples before and after cardiac surgery. Methods: In a substudy of the Translational ...
#1Dustin R. Bunch (Yale University)H-Index: 9
#2Joe M. El-Khoury (Yale University)H-Index: 5
Kidney disease is a major contributor to morbidity and mortality in the US, affecting 14% of the population. It is often referred to as a “silent epidemic” because the disease is often asymptomatic until the late stages and current clinical assays only detect it after a substantial portion of kidney capacity has been lost. As such, there is marked interest in kidney disease biomarkers that could identify the extent of kidney damage earlier in the pathological process. This may allow for interven...
#1Ahmad Charifa (Yale University)
#2Dustin R. Bunch (Yale University)H-Index: 9
Last.Joe M. El-Khoury (Yale University)H-Index: 5
view all 3 authors...
A 68-year-old man with a history of ischemic cardiomyopathy presented with decompensated heart failure and acute kidney injury. He was admitted to the coronary care unit for dopamine-assisted diuresis via a central line. Serum creatinine testing was performed using an enzymatic creatininase method (Roche cobas c701; Roche Diagnostics), revealing erratic creatinine concentrations …
#1Girish N. Nadkarni (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 18
#2Steven G. Coca (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 19
Last.Charles L. Edelstein (University of Colorado Denver)H-Index: 46
view all 13 authors...
Abstract Introduction Urinary biomarkers of kidney injury are presumed to reflect renal tubular damage. However, their concentrations may be influenced by other factors, such as hematuria or pyuria. We sought to examine what non-injury related urinalysis factors are associated with urinary biomarker levels. Methods We examined 714 adults who underwent cardiac surgery in the TRIBE-AKI cohort that did not experience post-operative clinical AKI (patients with serum creatinine change of ≥ 20% were e...
“It's not what you know, it's who you know,” so the popular saying goes; yet it is surprising how little attention is paid to developing networking skills vs technical skills in schools and colleges. Students are expected to somehow develop this essential skill on their own. Yet, not everyone does, and the negative impact on his or her professional development can be significant. When I think back to my own career, I owe a lot of opportunities that came my way to networking. At the top of that l...
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